Molecular Targets and Therapeutics Center

2024 Nature Cancer

Orberg ET, Meedt E, Andreas Hiergeist A , Xue J, Heinrich P, Ru J , Ghimire S, Miltiadous O, Lindner S, Tiefgraber M, Göldel S , Eismann T, Schwarz A, Göttert S, Jarosch S, Steiger K, Schulz C , Gigl M, Fischer JC, Janssen K-P, Quante M, Heidegger S, Herhaus P, Verbeek M, Ruland J, van den Brink MRM, Weber D, Edinger M, Wolff D, Busch DH, Kleigrewe K, Herr W, Bassermann F, Gessner A*, Deng L*, Holler E*, Poeck H*

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

2023 Signal Transduction and Targeted Therapy

Boes M and Falter-Braun P*

Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system

2023 Blood

Wimberger N, Ober F, Avar G, Grau M, Xu W, Lenz G, Menden MP, Krappmann D*

Oncogene-induced MALT1 protease activity drives post-transcriptional gene expression in malignant lymphomas

2023 Nature Structural & Molecular Biology

Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M*

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.

2023 Gut

Luo S, Ru J, Khan Mirzaei M, Xue J, Peng X, Ralser A, Hadi JL, Mejías-Luque R, Gerhard M and Deng L*

Helicobacter pylori infection alters gut virome by expanding temperate phages linked to increased risk of colorectal cancer.

2023 Nat. Commun.

Ratajczak F, Joblin M, Hildebrandt M, Ringsquandl M, Falter-Braun P*, Heinig M*

Speos: An ensemble graph representation learning framework to predict core genes for complex diseases

2023 Proc Natl Acad Sci U S A

Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

2023 Molecular Cell

Khurana A, Chadha Y, Schmoller KM

Too big not to fail: Different paths lead to senescence of enlarged cells

2023 Nature Communications

Tschuck J, Theilacker L, Rothenaigner I, Weiß SAI, Akdogan B, Lam VT, Müller C, Graf R, Brandner S, Pütz C, Rieder T, Schmitt-Kopplin P, Vincendeau M, Zischka H, Schorpp K, and Hadian K*

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

2023 Molecular Cell

Ebersberger S, Hipp C, Mulorz MM, Buchbender A, Hubrich D, Kang H-S, Martinez-Lumbreras S, Kristofori P, Sutandy FXR, Allcca LL, Schönfeld S, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M*, König J*

FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns

2023 Nature reviews drug discovery

Hadian K, Stockwell BR

The therapeutic potential of targeting regulated non-apoptotic cell death.

2023 Nat. Commun.

Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J & Sattler M

Structural basis for specific RNA recognition by the alternative splicing factor RBM5

2023 Nucleic Acids Research

Witzenberger M, Burczyk S, Settele D, Mayer W, Welp LM, Heiss M, Wagner M, Monecke T, Janowski R, Carell T, Urlaub H, Hauck SM, Voigt A*, Niessing D*

Human TRMT2A methylates tRNA and contributes to translation fidelity

2023 Nat. Commun.

Osborne R, Rehneke L, Lehmann S, Roberts J, Altmann M, Altmann S, Zhang Y, Köpff E, Dominguez-Ferreras A, Okechukwu E, Sergaki C, Rich-Griffin C, Ntoukakis V, Eichmann R, Shan W, Falter-Braun P* & Schäfer P*

Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion

2023 Molecular Therapy

Ji H , Englmaier F , Morigny P , Giroud M, Gräsle P , Brings S , Szendrödi J , Diaz MB , Plettenburg O* , Herzig S* , Rohm M*

Development of a peptide drug restoring AMPK and adipose tissue functionality in cancer cachexia

2023 Nature Cell Death Discovery

Schorpp K, Bessadok A, Rothenaigner I, Strasser S, Peng T*, Hadian K*

CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting

2023 Nature

Mishima E, Nakamura T, Zheng J, Zhang W, Mourao ASD, Sennhenn P, Conrad M*

DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

2023 Nat. Commun.

Pradhan T, Sarkar R, Meighen-Berger KM, Feige MJ, Zacharias M & Reif B

Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005

2023 Nature

Nakamura T, Hipp C, Santos Dias Mourao A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M*

Phase separation of FSP1 promotes ferroptosis

2023 Nature Metabolism

Mishima E*, Wahida A, Seibt T, Conrad M*

Diverse biological functions of vitamin K: from coagulation to ferroptosis

2023 Nature Cell Biology

Mishima E, Conrad M.*

Nonmetabolic role for CKB in ferroptosis

2023 Journal of Hepatology

Su J, Brunner L, Oz EA, Sacherl J, Frank G, Kerth HA, Thiele F, Wiegand M, Mogler C, Aguilar JC, Knolle PA, Collin N, Kosinska AD*, Protzer U*

Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models

2023 Cancer Treatments Reviews

O'Neill TJ, Tofaute MJ, Krappmann D*

Function and targeting of MALT1 paracaspase in cancer

2023 ACS Applied Materials & Interfaces

Bronner H, Brunswig F, Pluta P, Krysiak Y, Bigall N, Plettenburg O* and Polarz S*

Cooperative Functionalities in Porous Nanoparticles for Seeking Extracellular DNA and Targeting Pathogenic Biofilms via Photodynamic Therapy

2023 Gastroenerology

Einer C, Munk DE, Park E, Akdogan B, Nagel J, Lichtmannegger J, Eberhagen C, Rieder T, Vendelbo MH, Michalke B, Wimmer R, Blutke A, Feuchtinger A, Dershwitz P, DiSpirito AM, Islam T, Castro RE, Min BK, Kim T, Choi S, Kim D, Jung C, Lee H, Park D, Im W, Eun SY, Cho YH, Semrau JD, Rodrigues CMP, Hohenester S, Damgaard Sandahl T, Di Spirito AA, Zischka H*

ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease Rats

2023 Nucleic Acids Research

Molitor L, Klostermann M, Bacher S, Merl-Pham J, Spranger N, Burczyk S, Ketteler C, Rusha E, Tews D, Pertek A, Proske M, Busch A, Reschke S, Feederle R, Hauck SM, Blum H, Drukker M, Fischer-Posovszky P, König J, Zarnack K*, Niessing D*

Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies.

2023 Nucleic Acids Research

Keil P, Wulf A, Kachariya N, Reuscher S, Hühn K, Silbern I, Altmüller J, Keller M, Stehle R, Zarnack K, Sattler M*, Urlaub H*, Sträßer K*

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA

2023 Nat Biotechnol.

Kim DK, Weller B, Lin CW, Sheykhkarimli D, Knapp JJ, Dugied G, Zanzoni A, Pons C, Tofaute MJ, Maseko SB, Spirohn K, Laval F, Lambourne L, Kishore N, Rayhan A, Sauer M, Young V, Halder H, la Rosa NM, Pogoutse O, Strobel A, Schwehn P, Li R, Rothballer ST, Altmann M, Cassonnet P, Coté AG, Vergara LE, Hazelwood I, Liu BB, Nguyen M, Pandiarajan R, Dohai B, Coloma PAR, Poirson J, Giuliana P, Willems L, Taipale M, Jacob Y, Hao T, Hill DE, Brun C, Twizere JC, Krappmann D, Heinig M, Falter C, Aloy P, Demeret C, Vidal M, Calderwood MA, Roth FP, Falter-Braun P

A proteome-scale map of the SARS-CoV-2-human contactome