Molecular Targets and Therapeutics Center
Unser Ziel ist die Entschlüsselung von biologischen Signalwegen und molekularen Mechanismen, die physiologische und krankheitsbezogene zelluläre Prozesse steuern, und damit neue Zielstrukturen zu identifizieren und innovative therapeutische Konzepte zu entwickeln.
Unsere Forschungsbereiche
MTTC Mission
Externer Inhalt
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Institutsleiter
Head of the Molecular Targets and Therapeutics Centers, Director Structural Biology, Molecular Targets and Therapeutics Center, Institute of Structural Biology
Profil anzeigenDeputy Head of the Molecular Targets and Therapeutics Center, Director Virology
Profil anzeigenDirector of Molecular Toxicology and Pharmacology
Unsere Institute
Unsere Forschungsplattformen
Forschungsgruppen am MTTC
Experimental Medical Physics
Bartzsch Group
Immunmonitoring
Bauer Group
Environment and Nuclear Organization
Cabianca Group
Environment and Nuclear Organization
Combs Group
Metabolism and Cell Death
Conrad Group
Microbial Diseases Prevention
Deng Group
Mitochondrial Metabolism
Deshwal Group
Personalized Radiooncology
Dobiasch Group
Genetic Engineering and Gene Transfer
Doll Group
Cell Signaling and Cell Death
Ebert Group
Small molecule modulators of intermediary metabolism
Göttlicher Group
Epigenetics, Metabolism, and Acclimation
Groth Group
Cell Signaling and Chemical Biology
Hadian Group
Structural Membrane Biochemistry
Hagn Group
Bioinformatics
Hansen Group
Viral signal transduction and therapeutic intervention strategie
Kieser Group
Cellular Signal Integration
Krappmann Group
EBV immunity
Mautner Group
RNA localization and intracellular transport
Niessing Group
Tissue control of Immunocytes
Noessner Group
Artificial Intelligence and Radiomics in Radiation Oncology
Peeken Group
Medical Chemistry
Plettenburg Group
Structure Based Drug Discovery
Popowicz Group
Drug Discovery and Development
Proneth Group
Chronic viral hepatitis
Protzer Group
Solid state NMR of amyloids and membrane proteins
Reif Group
Molecular recognition in the regulation of gene expression and signaling
Sattler Group
Genetics and Cellular Engineering
Schick Group
Radiobiology
Schmid Group
Cell and Organelle Size Control
Schmoller Group
Chromatin Dynamics and Epigenetics
Schneider Group
Physics and data-based modelling of cellular decision making
Scialdone Group
Metabolic therapy response
Selmansberger Group
Informatics & Chemical Biology
Tetko Group
Human Endogenous Retroviruses
Vincendeau Group
Therapeutic Antibodies
Zeidler Group
Mitochondrial Toxicology
Zischka Group
Assoziierte Forschungsgruppen
Marion Jasnin
The Cryoskeleton Lab
Jian Cui
The nanoProbe Lab
Ausgewählte Publikationen
Orberg ET, Meedt E, Andreas Hiergeist A , Xue J, Heinrich P, Ru J , Ghimire S, Miltiadous O, Lindner S, Tiefgraber M, Göldel S , Eismann T, Schwarz A, Göttert S, Jarosch S, Steiger K, Schulz C , Gigl M, Fischer JC, Janssen K-P, Quante M, Heidegger S, Herhaus P, Verbeek M, Ruland J, van den Brink MRM, Weber D, Edinger M, Wolff D, Busch DH, Kleigrewe K, Herr W, Bassermann F, Gessner A*, Deng L*, Holler E*, Poeck H*
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantationBoes M and Falter-Braun P*
Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune systemWimberger N, Ober F, Avar G, Grau M, Xu W, Lenz G, Menden MP, Krappmann D*
Oncogene-induced MALT1 protease activity drives post-transcriptional gene expression in malignant lymphomasNakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M*
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.Luo S, Ru J, Khan Mirzaei M, Xue J, Peng X, Ralser A, Hadi JL, Mejías-Luque R, Gerhard M and Deng L*
Helicobacter pylori infection alters gut virome by expanding temperate phages linked to increased risk of colorectal cancer.Ratajczak F, Joblin M, Hildebrandt M, Ringsquandl M, Falter-Braun P*, Heinig M*
Speos: An ensemble graph representation learning framework to predict core genes for complex diseasesSchmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V.
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.Khurana A, Chadha Y, Schmoller KM
Too big not to fail: Different paths lead to senescence of enlarged cellsTschuck J, Theilacker L, Rothenaigner I, Weiß SAI, Akdogan B, Lam VT, Müller C, Graf R, Brandner S, Pütz C, Rieder T, Schmitt-Kopplin P, Vincendeau M, Zischka H, Schorpp K, and Hadian K*
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosisHadian K, Stockwell BR
The therapeutic potential of targeting regulated non-apoptotic cell death.Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J & Sattler M
Structural basis for specific RNA recognition by the alternative splicing factor RBM5Witzenberger M, Burczyk S, Settele D, Mayer W, Welp LM, Heiss M, Wagner M, Monecke T, Janowski R, Carell T, Urlaub H, Hauck SM, Voigt A*, Niessing D*
Human TRMT2A methylates tRNA and contributes to translation fidelityOsborne R, Rehneke L, Lehmann S, Roberts J, Altmann M, Altmann S, Zhang Y, Köpff E, Dominguez-Ferreras A, Okechukwu E, Sergaki C, Rich-Griffin C, Ntoukakis V, Eichmann R, Shan W, Falter-Braun P* & Schäfer P*
Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotionJi H , Englmaier F , Morigny P , Giroud M, Gräsle P , Brings S , Szendrödi J , Diaz MB , Plettenburg O* , Herzig S* , Rohm M*
Development of a peptide drug restoring AMPK and adipose tissue functionality in cancer cachexiaPradhan T, Sarkar R, Meighen-Berger KM, Feige MJ, Zacharias M & Reif B
Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005Su J, Brunner L, Oz EA, Sacherl J, Frank G, Kerth HA, Thiele F, Wiegand M, Mogler C, Aguilar JC, Knolle PA, Collin N, Kosinska AD*, Protzer U*
Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse modelsO'Neill TJ, Tofaute MJ, Krappmann D*
Function and targeting of MALT1 paracaspase in cancerBronner H, Brunswig F, Pluta P, Krysiak Y, Bigall N, Plettenburg O* and Polarz S*
Cooperative Functionalities in Porous Nanoparticles for Seeking Extracellular DNA and Targeting Pathogenic Biofilms via Photodynamic TherapyEiner C, Munk DE, Park E, Akdogan B, Nagel J, Lichtmannegger J, Eberhagen C, Rieder T, Vendelbo MH, Michalke B, Wimmer R, Blutke A, Feuchtinger A, Dershwitz P, DiSpirito AM, Islam T, Castro RE, Min BK, Kim T, Choi S, Kim D, Jung C, Lee H, Park D, Im W, Eun SY, Cho YH, Semrau JD, Rodrigues CMP, Hohenester S, Damgaard Sandahl T, Di Spirito AA, Zischka H*
ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease RatsMolitor L, Klostermann M, Bacher S, Merl-Pham J, Spranger N, Burczyk S, Ketteler C, Rusha E, Tews D, Pertek A, Proske M, Busch A, Reschke S, Feederle R, Hauck SM, Blum H, Drukker M, Fischer-Posovszky P, König J, Zarnack K*, Niessing D*
Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies.Keil P, Wulf A, Kachariya N, Reuscher S, Hühn K, Silbern I, Altmüller J, Keller M, Stehle R, Zarnack K, Sattler M*, Urlaub H*, Sträßer K*
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNAKim DK, Weller B, Lin CW, Sheykhkarimli D, Knapp JJ, Dugied G, Zanzoni A, Pons C, Tofaute MJ, Maseko SB, Spirohn K, Laval F, Lambourne L, Kishore N, Rayhan A, Sauer M, Young V, Halder H, la Rosa NM, Pogoutse O, Strobel A, Schwehn P, Li R, Rothballer ST, Altmann M, Cassonnet P, Coté AG, Vergara LE, Hazelwood I, Liu BB, Nguyen M, Pandiarajan R, Dohai B, Coloma PAR, Poirson J, Giuliana P, Willems L, Taipale M, Jacob Y, Hao T, Hill DE, Brun C, Twizere JC, Krappmann D, Heinig M, Falter C, Aloy P, Demeret C, Vidal M, Calderwood MA, Roth FP, Falter-Braun P
A proteome-scale map of the SARS-CoV-2-human contactome