Molecular Targets and Therapeutics Center

2023 Proc Natl Acad Sci U S A

doi: 10.1073/pnas.2309205120

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

2023 Nat. Commun.

Ratajczak F, Joblin M, Hildebrandt M, Ringsquandl M, Falter-Braun P*, Heinig M*

Speos: An ensemble graph representation learning framework to predict core genes for complex diseases

2023 Blood

Wimberger N, Ober F, Avar G, Grau M, Xu W, Lenz G, Menden MP, Krappmann D*

Oncogene-induced MALT1 protease activity drives post-transcriptional gene expression in malignant lymphomas

2023 Nature reviews drug discovery

Hadian K, Stockwell BR

The therapeutic potential of targeting regulated non-apoptotic cell death.

2023 Nature Cell Death Discovery

Schorpp K, Bessadok A, Rothenaigner I, Strasser S, Peng T*, Hadian K*

CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting

2023 Molecular Cell

Ebersberger S, Hipp C, Mulorz MM, Buchbender A, Hubrich D, Kang H-S, Martinez-Lumbreras S, Kristofori P, Sutandy FXR, Allcca LL, Schönfeld S, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M*, König J*

FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns

2023 Nature

Nakamura T, Hipp C, Santos Dias Mourao A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M*

Phase separation of FSP1 promotes ferroptosis

2023 Nature

Mishima E, Nakamura T, Zheng J, Zhang W, Mourao ASD, Sennhenn P, Conrad M*

DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

2023 Nature Metabolism

Mishima E*, Wahida A, Seibt T, Conrad M*

Diverse biological functions of vitamin K: from coagulation to ferroptosis

2023 Nucleic Acids Research

Keil P, Wulf A, Kachariya N, Reuscher S, Hühn K, Silbern I, Altmüller J, Keller M, Stehle R, Zarnack K, Sattler M*, Urlaub H*, Sträßer K*

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA

2023 Nat Biotechnol.

Kim DK, Weller B, Lin CW, Sheykhkarimli D, Knapp JJ, Dugied G, Zanzoni A, Pons C, Tofaute MJ, Maseko SB, Spirohn K, Laval F, Lambourne L, Kishore N, Rayhan A, Sauer M, Young V, Halder H, la Rosa NM, Pogoutse O, Strobel A, Schwehn P, Li R, Rothballer ST, Altmann M, Cassonnet P, Coté AG, Vergara LE, Hazelwood I, Liu BB, Nguyen M, Pandiarajan R, Dohai B, Coloma PAR, Poirson J, Giuliana P, Willems L, Taipale M, Jacob Y, Hao T, Hill DE, Brun C, Twizere JC, Krappmann D, Heinig M, Falter C, Aloy P, Demeret C, Vidal M, Calderwood MA, Roth FP, Falter-Braun P

A proteome-scale map of the SARS-CoV-2-human contactome