Bauer Lab
The main focus of our research is the analysis of the phenotype and functional properties of different immune cell populations mainly in the context of clinical trials. By doing so, we are aiming for an in depth understanding of cellular virus-host interactions to support the development of novel therapeutic interventions, e.g. by prediction of biomarker that identifies target engagement and predicts response to therapeutic interventions.
The main focus of our research is the analysis of the phenotype and functional properties of different immune cell populations mainly in the context of clinical trials. By doing so, we are aiming for an in depth understanding of cellular virus-host interactions to support the development of novel therapeutic interventions, e.g. by prediction of biomarker that identifies target engagement and predicts response to therapeutic interventions.
About our research
Comprehensive monitoring of anti-viral immunity increases our understanding of virus-host interaction thus supporting identification of new biomarkers predictive of response to vaccination or treatment. To evaluate the impact of immunotherapies it is necessary to have reliable and validated monitoring tools available to analyze and assess immunogenicity endpoints in clinical trials.
Therefore the development, establishment and validation of different state-of-the-art immunoassays to be used as immunogenicity endpoint assays in clinical trials is a central aim of the Immune Monitoring Group. We also establish and conduct inter-laboratory round robin tests for immunological endpoint assay and data analysis standardization to ensure reliable data across trial site in multicenter trials.
We are currently escorting several clinical trials with the aim to evaluate efficacy and immunogenicity of novel vaccines and therapeutic interventions. In addition to the assessment of immunity in Hepatitis B virus-related interventional studies, immune responses towards various viral infections (SARS-Coronavirus-2, Epstein-Barr virus and HBV) are monitored as part of observational studies for different patient cohorts.
Publications
Read more2024 Scientific Article in Virology Journal