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Helmholtz Munich | © MCD

Molecular Targets and Therapeutics Center Metabolism and Cell Death

The Institute of Metabolism and Cell Death aims to elucidate the molecular mechanisms underlying life and death decisions in (patho-)physiological contexts. Understanding these mechanisms is central to both the identification of biomarkers and the development of new therapies to combat degenerative diseases and cancer.

The Institute of Metabolism and Cell Death aims to elucidate the molecular mechanisms underlying life and death decisions in (patho-)physiological contexts. Understanding these mechanisms is central to both the identification of biomarkers and the development of new therapies to combat degenerative diseases and cancer.

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About our Research

We are convinced that a detailed mechanistic understanding of the molecular mechanisms underlying metabolic cell death or leaving a vulnerability to these forms of cell death will provide us unique opportunities to combat these often fatal diseases.

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Helmholtz Munich | © MCD

Our Research Groups

Drug Discovery and Development

Ferroptotic cell death is thought to be the root cause of many degenerative diseases while ferroptosis suppression has been put forward as Achilles’ heel for therapy-resistant tumors. Ferroptosis modulators have a vast potential for the treatment of as-yet-incurable diseases

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Genetic Engineering and Gene Transfer

We develop novel tools to halt ferroptosis by genetic engineering and gene transfer. The delivery of anti-ferroptotic genes combined with CRISPR/Cas9 technology is at the core of our research.

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Bioinformatics

The management and analysis of increasingly large amounts of research data is of enormous importance for the understanding of fundamental metabolic processes, their regulation and the subsequent development of innovative approaches to disease therapy.

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Projects & Cooperations

DFG Projekt SPP-1
German Research Foundation (DFG) - Priority Program SPP 2306

Ferroptosis: from Molecular Basics to Clinical Applications

Awards & Grants, MCD,

Marcus Conrad as a new member of the Hinterzarten Circle of the DFG on Cancer Research

The Review Board for Medicine of the Deutsche Forschungsgemeinschaft (DFG) has appointed Helmholtz Munich scientist Dr. Marcus Conrad as a new member of the DFG’s Hinterzarten Circle on Cancer Research. Marcus Conrad succeeds Prof. Greten from…

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MCD,

"Highly Cited Researchers" 2022

Marcus Conrad is listed as one of the most influential scientists for the third year in a row

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Vitamin K prevents cell death
New Research Findings, MCD,

Vitamin K Prevents Cell Death: A New Function for a Long-Known Molecule

A team of researchers located at Helmholtz Munich reports on a novel function of vitamin K, which is generally known for its importance in blood clotting. The researchers discovered that the fully reduced form of vitamin K acts as an antioxidant…

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Our Scientists at Metabolism and Cell Death

Dr. Bettina Proneth

Deputy Director

Dr. Jens Hansen

Group Leader
Porträt Marceler Aldrovandi

Dr. Maceler Aldrovandi

Group Leader

Dr. Sebastian Doll

Group Leader

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Tweets of our Institute

Latest Publications of Our Institute

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2022 Scientific Article in Nature

Mishima, E. ; Ito, J. ; Wu, Z. ; Nakamura, T. ; Wahida, A. ; Doll, S. ; Tonnus, W. ; Nepachalovich, P. ; Eggenhofer, E. ; Aldrovandi, M. ; Henkelmann, B. ; Yamada, K.i. ; Wanninger, J. ; Zilka, O. ; Sato, E. ; Feederle, R. ; Hass, D, ; Maida, A. ; Mourao, A. ; Linkermann, A. ; Geissler, E.K. ; Nakagawa, K. ; Abe, T. ; Fedorova, M. ; Proneth, B. ; Pratt, D.A. ; Conrad, M.

A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Networks and Affiliations

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Bundesministerium für Bildung und Forschung

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Deutsche Forschungsgemeinschaft (DFG)

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European Research Council (ERC)

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Helmholtz-Gemeinschaft (HGF)

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Else Kröner Fresenius Stiftung

Contact

Institute Office

Silvia Köhn

Office