Molecular Targets and Therapeutics Center Metabolism and Cell Death

Ferroptotic cell death is thought to be the root cause of many degenerative diseases while ferroptosis suppression has been put forward as Achilles’ heel for therapy-resistant tumors. Ferroptosis modulators have a vast potential for the treatment of as-yet-incurable diseases

We develop novel tools to halt ferroptosis by genetic engineering and gene transfer. The delivery of anti-ferroptotic genes combined with CRISPR/Cas9 technology is at the core of our research.

The management and analysis of increasingly large amounts of research data is of enormous importance for the understanding of fundamental metabolic processes, their regulation and the subsequent development of innovative approaches to disease therapy.