Molecular Targets and Therapeutics Center
Metabolism and Cell Death
The Institute of Metabolism and Cell Death (MCD) aims to elucidate the molecular mechanisms underlying life and death decisions in (patho-)physiological contexts. Understanding these mechanisms is central to both the identification of biomarkers and the development of new therapies to combat degenerative diseases and cancer.
Deputy Director
Group Leader
Group Leader
Group Leader
Latest Publications of Our Institute
Barayeu, U. ; Ogata, S. ; Takata, T. ; Jung, M. ; Matsunaga, T. ; Morita, M. ; Ida, T. ; Lange, M. ; Unno, Y. ; Boushehri, S. ; Greicius, P. ; Nishimura, A. ; Catti, L. ; Pan, Y. ; Zhang, T. ; Shimizu, T. ; Ushioda, R. ; Nakabayashi, T. ; Asamitsu, S. ; Fusegawa, K. ; Suzuki, T. ; Ishida, T. ; Tanda, N. ; Watanabe, Y. ; Tsuchiya, Y. ; Yamaguchi, R. ; Noguchi, S. ; Mishima, E. ; Yano, F. ; Arisawa, M. ; Stuehr, D.J. ; Xia, N. ; Li, H. ; Moosmann, B. ; Gräter, F. ; Aponte-Santamaría, C. ; Olzmann, J.A. ; Conrad, M. ; van der Vliet, A. ; Dick, T.P. ; Motohashi, H. ; Yoshizawa, M. ; Akaike, T.
Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis.Seibt, T. ; Hoeft, K. ; Schaefer, G.J.L. ; Wahida, A. ; Kurzrock, R. ; Conrad, M. ; Kramann, R.
Mechanisms of regeneration and maladaptive repair in acute kidney injury.Mayer, C. ; Woo, M.S. ; Sonner, J.K. ; Binkle-Ladisch, L. ; Fischbach, F. ; Sekol, P. ; Smith, M.D. ; Lucas-Ruiz, F. ; Manteufel, D. ; Mattern, K.M.J. ; Pfeffer, L.K. ; Guo, Y. ; Siebels, B. ; Miguela, A. ; Vieira, V. ; Meurs, N. ; Bauer, S. ; Schwarz, S. ; Wulf, S. ; Mühlig, A.K. ; Engler, J.B. ; Conrad, M. ; Bareyre, F.M. ; Wiech, T. ; Krasemann, S. ; Glatzel, M. ; Zipfel, P.F. ; Freiwald, T. ; Calabresi, P.A. ; Schirmer, L.
Intracellular complement factor H protects neurons during CNS inflammation.Zheng, J. ; Zhang, W. ; Conrad, M.
Ferroptosis induction via genetic approaches - CRISPR/Cas9-based disruption on key anti-ferroptotic genes.Yinuo, W. ; Toyama, T. ; Yamakoshi, H. ; Taguchi, H. ; Takashima, H. ; Watanabe, R. ; Mita, Y. ; Ito, J. ; Mishima, E. ; Akiyama, Y. ; Shibata, H. ; Noguchi, N. ; Takamura, T. ; Conrad, M. ; Tomikoka, Y. ; Iwabuchi, Y. ; Saito, Y.
Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network.Conrad, M. ; Strasser, A. ; Jost, P.J. ; Yuan, J. ; Shao, F. ; Vandenabeele, P. ; Wahida, A.
Cell death in cancer.Jacobs, L.J. ; Doll, S. ; Trümbach, D. ; Veronese, M. ; Di Pietro, G. ; Yapici, F.I. ; Hasberg, L. ; Gentzsch, P. ; Gerlich, S. ; Hansen, J. ; von Karstedt, S. ; Rugarli, E.I. ; Conrad, M. ; Salvador, A. ; Riemer, J.
Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial H2O2 levels and enable resilience to chronic mitochondrial oxidative stress.
Contact Institute Director
Contact Institute Office
