Banner Sabine Steffens

Head of Division "Cardiovascular Disease Comorbidities"

Prof. Dr. Sabine Steffens

“My research focuses on the role of endogenous lipid signaling pathways in inflammatory processes that underlie atherosclerosis and adverse cardiac remodeling. It is a great privilege to conduct my research at the interface between cardiovascular and metabolic diseases in a vibrant scientific environment in collaboration with experts from both research areas.”

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Academic Career and Research Areas

Sabine Steffens studied biology in Giessen and obtained her PhD in Düsseldorf, Germany. After earning her Ph.D. in gene therapy and completing a short postdoctoral training in Philadelphia, she worked at the Medical Faculty in Geneva, Switzerland, for several years. In 2013, she has been appointed as a professor at Ludwig-Maximilians-University (LMU) of Munich, and since 2024 she is also an associated group leader at the IDC at Helmholtz Munich.

Some of her recent key studies on the role of innate immune responses in post-myocardial infarction healing and the influence of the circadian rhythm on these processes have been published in European Heart Journal, EMBO Molecular Medicine and Circulation. More recent work on the role of the lipid receptor GPR55 in regulating B cell function in the context of atherosclerosis has been published in Nature Cardiovascular Research.

She has received several awards, including the Cardiovascular Biology Award from the Swiss Society of Cardiology and the Outstanding Achievement Award from the European Society of Cardiology. She is also an active member of several commissions of the German Cardiac Society and the European Society of Cardiology. Additionally, she is involved in mentoring and coordinating training networks for the next generation of cardiovascular scientists.

Fields of Work and Expertise

Cardiovascular Biology Circadian Biology  Metabolic Diseases Inflammation & Immunometabolism

Lipid Signalling

Professional Background

Since 2024

Associated Group Leader, Cardiovascular Disease Comorbidities, Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Germany

Since 2013

W2 Professor, Institute for Cardiovascular Prevention, LMU Munich, Germany

2012

Habilitation, “The role of the endocannabinoid system in the pathogenesis of atherosclerosis”, Medical Faculty of Geneva, Switzerland

2003 - 2013

Postdoc and Junior group leader, Medical Faculty of Geneva, Switzerland

2012

DFG Postdoc Fellowship, Children´s Hospital Philadelphia, USA

Honors and Awards

  • 2023 - Arthur Weber Price and Silver Honorary Needle of the German Cardiac Society
  • 2016 – European Society of Cardiology Outstanding Achievement Award
  • 2013 – Denber Pinard Award, Faculty of Medicine, University of Geneva
  • 2005 – Swiss Society of Cardiology Research Award

Highlight Publications

Nature Cardiovascular Research

Guillamat-Prats R, Hering D, Rami M, Härdtner C, Santovito D, Rinne P, Bindila L, Hristov M, Pagano S, Vuilleumier N, Schmid S, Janjic A, Enard W, Weber C, Maegdefessel L, Faussner A, Hilgendorf I, Steffens S. 2022

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation.
Cardiovascular Research

Schloss MJ*, Horckmans M*, Guillamat-Prats R, Hering D, Lauer E, Lenglet S, Weber C, Thomas A, Steffens S. 2019

2-arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction.
Arteriosclerosis, Thrombosis, and Vascular Biology

Rinne P, Guillamat-Prats R, Rami M, Bindila L, Ring L, Lyytikäinen LP, Raitoharju E, Oksala N, Lehtimäki T, Weber C, van der Vorst EPC, Steffens S. 2018

Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation.
Circulation

Horckmans M, Bianchini M, Santovito D, Megens RTA, Springael JY, Negri I, Vacca M, Eusanio M, Moschetta A, Weber C, Duchene J, Steffens S. 2017

Pericardial adipose tissue regulates granulopoiesis, fibrosis and cardiac function after myocardial infarction.

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