Member and Spokesperson of the Executive Board (acting), Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich Germany, Director of the Institute of Experimental Genetics Helmholtz Munich
Martin Hrabě De Angelis Prof. Dr. Dr. H.C. Mult.
Prof. Hrabě de Angelis’ areas of research include genetics, diabetes, phenotyping and data mining.
Martin Hrabě de Angelis studied biology at Philipps University in Marburg and completed his PhD on the influence of growth factors on early embryonic development in 1994. During his time as a postdoctoral researcher (1994 – 1997) at the internationally recognized Jackson Laboratory in Bar Harbor (USA), he examined the Delta/Notch signaling pathway and somitogenesis in mouse models. Deciphering the genetic underpinning for pattern formation of the body axis has been a major focus. Already at that time modelling human health and disease has been of major interest.
In 1997 he returned to Germany and headed the working group “Functional Genetics” at the Institute for Mammalian Genetics GSF, Munich. Together with Prof. Rudi Balling and colleagues he successfully performed the first comprehensive ENU-mutagenesis screen for disease models, resulting in great many new models, which have been used in the own laboratory and world-wide.
In 2001, Martin founded the world first Mouse Clinic (German Mouse Clinic) for the systemic analysis of mouse models for human disease including a special focus on metabolism. This was possible in his new position as director of the Institute of Experimental Genetics at Helmholtz Munich (German Research Center for Environmental Health). In 2003, he was appointed to the Chair of Experimental Genetics at Technical University Munich. He is also the director of the European research consortium "INFRAFRONTIER ERIC".
Hrabě de Angelis and colleagues have shown that dietary obesity and diabetes mellitus can be epigenetically inherited from the offspring via egg cells as well as sperm. By studying knockout mice, each of which lacked a precisely selected gene, he succeeded in identifying 51 unknown genes that could play an important role in the development of metabolic diseases and diabetes. His published research articles, have been cited over 52 000 times. Martin Hrabě de Angelis directs national and international research projects. He is co-founder and board member of the German Center for Diabetes Research (DZD, 2009). He is also elected member of the National Academy of Science (Leopoldina)
- Speaker and member of the board: German Center for Diabetes Research (DZD)
- CEA/CSO: INFRAFRONTIER Ltd. Non for profit
- Member of the Excecutive Board IMPC
- Co-founder of two biotech companies
Fields of Work and Expertise
Metabolism & Diabetes Large Scale Functional Genomics/Genetics Epigenetics Data Mining
Professional Background
Research Director Helmholtz Munich
Full Professor (W3) and Chair of Experimental Genetics Technical University München Germany
Director Institute of Experimental Genetics, Helmholtz Munich
1997-2000: Independent group leader within the German Human Genome Project (DHGP) and coordinator of the ENU mutagenesis project at the Institute of Mammalian Genetics, GSF, Munich
Postdoctoral fellow at Jackson Laboratory, Bar Harbor, ME, USA (DFG and NIH stipend)
PhD in Biology at Philipps University Marburg (summa cum laude)
Study Biology, Sports, Pedagogy at Philipps University Marburg, (State examination passed with distinction)
Honors and Awards
- Paul Langerhans Medal – Highest recognition of the DDG (German Diabetes Society) 2021
- IMPC award of excellence 2019
- Member of the National Academy of Sciences LEOPOLDINA 2018
- Dr. med. honoris causa Technical University Dresden Germany 2018
- Dr. vet. med. honoris causa. Ludwig Maximilian University Munich Germany 2017
- Dr. med. honoris causa Eberhard-Karls University Tübingen Germany 2016
- Paula und Richard von Hertwig award for interdisciplinary research 2003 & 2010
- JAX/NIH stipend postdoctoral fellow 1996-97
- DFG Stipend as postdoctoral fellow 1994-96
- Summa cum laude for overall performance PhD 1994
Selected Publications
Lorenz, S. ; Wahida, A. ; Bostock, M.J. ; Seibt, T. ; Santos Dias Mourão, A. ; Levkina, A. ; Trümbach, D. ; Soudy, M. ; Emler, D. ; Rothammer, N. ; Woo, M.S. ; Sonner, J.K. ; Novikova, M. ; Henkelmann, B. ; Aldrovandi, M. ; Kaemena, D.F. ; Mishima, E. ; Vermonden, P. ; Zong, Z. ; Cheng, D. ; Nakamura, T. ; Ito, J. ; Doll, S. ; Proneth, B. ; Bürkle, E. ; Rizzollo, F. ; Escamilla Ayala, A. ; Napolitano, V. ; Kolonko, M. ; Gaussmann, S. ; Merl-Pham, J. ; Hauck, S.M. ; Pertek, A. ; Orschmann, T. ; Van San, E. ; Vanden Berghe, T. ; Hass, D, ; Maida, A. ; Frenz, J.M. ; Pedrera, L. ; Dolga, A.M. ; Kraiger, M. ; Hrabě de Angelis, M. ; Fuchs, H. ; Ebert, G. ; Lenberg, J. ; Friedman, J. ; Scale, C. ; Agostinis, P. ; Zimprich, A. ; Vogt Weisenhorn, D.M. ; Garrett, L. ; Hölter, S.M. ; Wurst, W. ; Glaab, E. ; Lewerenz, J. ; Popper, B. ; Sieben, C. ; Steinacker, P. ; Zischka, H. ; García-Sáez, A.J. ; Tietze, A. ; Ramesh, S.K. ; Ayton, S. ; Vincendeau, M. ; Friese, M.A. ; Wigby, K. ; Sattler, M. ; Mann, M. ; Ingold, I. ; Jayavelu, A.K. ; Popowicz, G.M. ; Conrad, M.
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.Oestereicher, M.A. ; Ward, C.S. ; Schneltzer, E. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bou About, G. ; Selloum, M. ; Meziane, H. ; Stewart, M. ; Teboul, L. ; Norris, C.M. ; Pimm, D. ; Kan, M. ; Lopez Gomez, F. ; Wilson, R. ; Monroy, M. ; Pasha, S. ; Zabrodska, E. ; Prochazka, J. ; Pajuelo Reguera, D. ; Nichtová, Z. ; Herault, Y. ; Wells, S. ; Parkinson, H. ; Heaney, J.D. ; Sedlacek, R. ; Gao, X. ; Hrabě de Angelis, M. ; Spielmann, N.
Establishing standardized transthoracic echocardiography reference ranges for mouse models: Insights into the impact of anesthesia, sex, and age.Ehlich, H. ; Blease, A. ; Biju, R. ; Gustems, M. ; Song, F. ; Fessele, S. ; Massimi, M. ; Bozonelos, K. ; Ntafis, V. ; Hiltunen, A.E. ; Marschall, S. ; Stoeger, C. ; Khorshidi, Z. ; Ziadi, A. ; Jambou, K. ; Armagno, A. ; Scavizzi, F. ; Raspa, M. ; Fernández, J. ; del Hierro, M.J. ; Ayadi, A. ; Pensavalle, J. ; Prevost, G. ; Dufkova, L. ; Krupkova, M. ; Nickl, P. ; Krimpenfort, P. ; Jonkers, J. ; Valera Vazquez, G. ; Raess, M. ; Beckers, J. ; Moles, A. ; Dahlhoff, M. ; Montoliu, L. ; Herault, Y. ; Hinttala, R. ; Kontoyiannis, D.L. ; Sedlacek, R. ; Hrabě de Angelis, M. ; Boersma, A.A. ; Matteoni, R.
A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.Hinrichs, A. ; Pafili, K. ; Sancar, G. ; Laane, L. ; Zettler, S. ; Torgeman, M. ; Kessler, B. ; Nono, J.L. ; Kunz, S. ; Rathkolb, B. ; Barosa, C. ; Prehn, C. ; Cecil, A. ; Renner, S. ; Kemter, E. ; Kahl, S. ; Szendroedi, J. ; Bidlingmaier, M. ; Jones, J.G. ; Hrabě de Angelis, M. ; Roden, M. ; Wolf, E.
Corrigendum to "Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity" [Mol Metabol (2025) 102273].Harten, A. ; Schmidtke, M. ; Giesert, F. ; Skerrett-Byrne, D.A. ; Teperino, R. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.
MODY PDX1P33T: A mouse model reveals phenotypic divergence from human disease.Bhattacharya, D. ; da Silva Buttkus, P. ; Nalbach, K. ; Cheng, L. ; Garrett, L. ; Irmler, M. ; Kislinger, G. ; Werner, G. ; Rodde, R. ; Lengger, C. ; Beckers, J. ; Zimprich, A. ; Hölter, S.M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wefers, B. ; Wurst, W. ; Brill, M.S. ; Schifferer, M. ; Lichtenthaler, S.F. ; Behrends, C.
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.Winkler, R. ; Comas-Armangue, G. ; Corujo, D. ; Sanz-Moreno, A. ; Calzada-Wack, J. ; Bhattacharya, S.A. ; Rathkolb, B. ; Dragano, N.R.V. ; Qiao, C.X. ; Chiodi, V. ; Filipescu, D. ; Park, D.H. ; Domenici, M.R. ; Kirigin Callaú, V. ; Gerlini, R. ; Rozman, J. ; Klein-Rodewald, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Seisenberger, C. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bernstein, E. ; Vinciguerra, M. ; Oberdoerffer, P. ; Hrabě de Angelis, M. ; Teperino, R. ; Buschbeck, M.
Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.Hinrichs, A. ; Pafili, K. ; Sancar, G. ; Laane, L. ; Zettler, S. ; Torgeman, M. ; Kessler, B. ; Nono, J.L. ; Kunz, S. ; Rathkolb, B. ; Barosa, C. ; Prehn, C. ; Cecil, A. ; Renner, S. ; Kemter, E. ; Kahl, S. ; Szendroedi, J. ; Bidlingmaier, M. ; Jones, J.G. ; Hrabě de Angelis, M. ; Roden, M. ; Wolf, E.
Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity.Sandforth, A. ; Vazquez Arreola, E. ; Hanson, R.L. ; Wewer Albrechtsen, N.J. ; Holst, J.J. ; Ahrends, R. ; Coman, C. ; Gerst, F. ; Lorza-Gil, E. ; Cheng, Y. ; Sandforth, L. ; Katzenstein, S. ; Ganslmeier, M. ; Seissler, J. ; Hauner, H. ; Perakakis, N. ; Wagner, R. ; Machann, J. ; Schick, F. ; Peter, A. ; Lehmann, R. ; Weigert, C. ; Maurer, J. ; Preissl, H. ; Heni, M. ; Szendrödi, J. ; Kopf, S. ; Solimena, M. ; Schwarz, P. ; Blüher, M. ; Häring, H.-U. ; Hrabě de Angelis, M. ; Schürmann, A. ; Kabisch, S. ; Mai, K. ; Pfeiffer, A.F.H. ; Bornstein, S. ; Stumvoll, M. ; Roden, M. ; Stefan, N. ; Fritsche, A. ; Birkenfeld, A.L. ; Jumpertz von Schwartzenberg, R.
Prevention of type 2 diabetes through prediabetes remission without weight loss.van Karnebeek, C.D. ; Gailus-Durner, V. ; Engelke, U.F.H. ; Seisenberger, C. ; Marschall, S. ; Dragano, N.R.V. ; da Silva Buttkus, P. ; Leuchtenberger, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wevers, R.A. ; Coughlin, C.R. ; Lefeber, D.J.
New treatment for pyridoxine-dependent epilepsy due to ALDH7A1: First proof-of-principle of upstream enzyme inhibition in the mouse.
Chair of Task Force “Fight COVID19 @ Helmholtz Munich” (since 2020)
President of the International Mammalian Genome Society (IMGS) (2017-2019)
Member and Chair (since 2019) of the RIKEN Bioresource Research Center Advisory Board, Japan (since 2014)
Member of the Scientific Advisory Board MRC Harwell, UK (since 2014)
Member of external Council Board Karolinska Institute, Sweden (since 2014)
Member of the executive committee of the International Mouse Phenotyping Consortium (IMPC) (since 2009)
Founding member and chair of the board of the “German Center for Diabetes Research e.V.” (DZD) (since 2009)
