Martin Hrabě de Angelis

Member and Spokesperson of the Executive Board (acting), Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich Germany, Director of the Institute of Experimental Genetics Helmholtz Munich

+49 89 3187 3502 martin.hrabedeangelis@helmholtz-munich.de

Building / Room: 35.14 / 317

Prof. Hrabě de Angelis’ areas of research include genetics, diabetes, phenotyping and data mining.

Martin Hrabě de Angelis studied biology at Philipps University in Marburg and completed his PhD on the influence of growth factors on early embryonic development in 1994. During his time as a postdoctoral researcher (1994 – 1997) at the internationally recognized Jackson Laboratory in Bar Harbor (USA), he examined the Delta/Notch signaling pathway and somitogenesis in mouse models. Deciphering the genetic underpinning for pattern formation of the body axis has been a major focus. Already at that time modelling human health and disease has been of major interest.

In 1997 he returned to Germany and headed the working group “Functional Genetics” at the Institute for Mammalian Genetics GSF, Munich. Together with Prof. Rudi Balling and colleagues he successfully performed the first comprehensive ENU-mutagenesis screen for disease models, resulting in great many new models, which have been used in the own laboratory and world-wide.

In 2001, Martin founded the world first Mouse Clinic (German Mouse Clinic) for the systemic analysis of mouse models for human disease including a special focus on metabolism. This was possible in his new position as director of the Institute of Experimental Genetics at Helmholtz Munich (German Research Center for Environmental Health). In 2003, he was appointed to the Chair of Experimental Genetics at Technical University Munich. He served as founding director of the European research consortium "INFRAFRONTIER ERIC" and is now on the supervisory board / Assembly of members states.

Hrabě de Angelis and colleagues have shown that dietary obesity and diabetes mellitus can be epigenetically inherited from the offspring via egg cells as well as sperm. By studying knockout mice, each of which lacked a precisely selected gene, he succeeded in identifying 51 unknown genes that could play an important role in the development of metabolic diseases and diabetes. His published research articles, have been cited over 52 000 times. Martin Hrabě de Angelis directs national and international research projects. He is co-founder and board member of the German Center for Diabetes Research (DZD, 2009). He is also elected member of the National Academy of Science (Leopoldina), Member and Spokesperson of the Executive Board (acting), Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich Germany, Director of the Institute of Experimental Genetics Helmholtz Munich

Speaker and member of the board: German Center for Diabetes Research (DZD)
M1 Munich Medicine Alliance: Member of the Foundation Board
INFRAFRONTIER ERIC: Assembly of members states
Member of the Excecutive Board IMPC
Co-founder of two biotech companies

Metabolism & Diabetes Large Scale Functional Genomics/Genetics Epigenetics Data Mining

Since 2025

Since 2020

2003

2000

1997-2000

1994-1997

1994

1990

George Snell lecture 2025
Paul Langerhans Medal – Highest recognition of the DDG (German Diabetes Society) 2021
IMPC award of excellence 2019
Member of the National Academy of Sciences LEOPOLDINA 2018
Dr. med. honoris causa Technical University Dresden Germany 2018
Dr. vet. med. honoris causa. Ludwig Maximilian University Munich Germany 2017
Dr. med. honoris causa Eberhard-Karls University Tübingen Germany 2016
Paula und Richard von Hertwig award for interdisciplinary research 2003 & 2010
JAX/NIH stipend postdoctoral fellow 1996-97
DFG Stipend as postdoctoral fellow 1994-96
Summa cum laude for overall performance PhD 1994

Laurent, K. ; Hoffmann, S. ; Marschall, S. ; Richter, K.B. ; Teperino, R. ; Hrabě de Angelis, M. ; Skerrett-Byrne, D.A. ; Beckers, J.

Embryo transfer following IVF alters susceptibility to metabolic phenotypes in male mouse offspring compared to naturally conceived offspring.

Oestereicher, M.A. ; Ward, C.S. ; Schneltzer, E. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; About, G.B. ; Selloum, M. ; Meziane, H. ; Stewart, M. ; Teboul, L. ; Norris, C. ; Pimm, D. ; Kan, M. ; Gómez, F.L. ; Wilson, R. ; Monroy, M. ; Pasha, S. ; Zabrodska, E. ; Prochazka, J. ; Reguera, D.P. ; Nichtova, Z. ; Herault, Y. ; Wells, S. ; Parkinson, H. ; Heaney, J.D. ; Sedlacek, R. ; Gao, X. ; Hrabě de Angelis, M. ; Spielmann, N.

Correction: Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age.

Saad, C. ; Jung-Klawitter, S. ; Dimitrov, B. ; Aguilar-Pimentel, J.A. ; Becker, L. ; da Silva Buttkus, P. ; Dragano, N.R.V. ; Garrett, L. ; Hölter, S.M. ; Rathkolb, B. ; Sanz-Moreno, A. ; Spielmann, N. ; Fuchs, H. ; Gailus-Durner, V. ; Schaaf, C.P. ; la Marca, G. ; Damiano, R. ; Lefeber, D.J. ; Engelke, U. ; Hrabě de Angelis, M. ; Houten, S.M. ; Kölker, S.

Aminoadipate-semialdehyde synthase, a potential target for substrate reduction therapy in glutaric aciduria type 1.

Laurent, K. ; Teperino, R. ; Hrabě de Angelis, M. ; Skerrett-Byrne, D.A. ; Beckers, J.

Epigenetic legacy: The role of sperm miRNAs in the paternal inheritance of diabetes and obesity development.

Oestereicher, M.A. ; da Silva Buttkus, P. ; Gailus-Durner, V. ; Marschall, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Schneltzer, E. ; Spielmann, N.

Rethinking ratio-based normalization: A guide towards model-based approaches in heart weight analysis.

Hass, D, ; Madsen, A.N. ; da Silva Buttkus, P. ; Kjølbye, A.L. ; Støy, S. ; Nøhr-Meldgaard, J. ; Sandahl, T.D. ; Hrabě de Angelis, M. ; Jorgensen, R. ; Rohm, M. ; van de Bunt, M.

Lipidated Interleukin-22 reduces body weight and spares lean mass in mice by a novel gut acting mechanism additive to GLP-1 agonism.

Teperino, R. ; Adamová, M. ; Aljabali, S. M. ; Pai, S. ; Gerlini, R. ; Paez-Perez, I. ; Matz-Soja, M. ; Heyne, S. ; Lempradl, A. ; Basilicata, M.F. ; Hrabě de Angelis, M. ; Gebhardt, R. ; Schleicher, E. ; Häring, H.U. ; Pospisilik, J.A.

Liver-derived Indian Hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis.

Harada, M. ; Adam, J. ; Han, S. ; Shi, M. ; Ge, J. ; Lintelmann, J. ; Cecil, A. ; Zukunft, S. ; Prehn, C. ; Witting, M. ; Scheerer, M.F. ; Neschen, S. ; Irmler, M. ; Beckers, J. ; Adamski, J. ; Teupser, D. ; Linkohr, B. ; Gieger, C. ; Hrabě de Angelis, M. ; Peters, A. ; Wang-Sattler, R.

Urea cycle modulation by combined SGLT2 inhibitors and metformin.

Inau, E.T. ; Dedié, A. ; Anastasova, I. ; Schick, R. ; Fröhlich, B. ; Roden, M. ; Birkenfeld, A.L. ; Hrabě de Angelis, M. ; Preusse, M. ; Waltemath, D. ; Zeleke, A.A.

Lessons learned from implementing FAIRification workflows in diabetes research in Germany.

Trigg, N.A. ; Mulhall, J.E. ; Nixon, B. ; Laurent, K. ; Pai, S. ; Smyth, S.P. ; Burke, N.D. ; Beckers, J. ; Bromfield, E.G. ; Karr, T.L. ; Lord, T. ; Pleuger, C. ; Schjenken, J.E. ; Hrabě de Angelis, M. ; Teperino, R. ; Skerrett-Byrne, D.A.

Curating fertility—proteomic remodelling of sperm during epididymal transit.