Epigenetics @HelmholtzMunich

Dozens of researchers @Helmholtz Munich join forces to reveal the myriad of secrets of Epigenetics.

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Dozens of researchers at Helmholtz Munich joined forces

to reveal the myriad of secrets of Epigenetics.

The Epigenetics@HelmholtzMunich Community Research consists of almost 30 labs from 17 Helmholtz Munich institutes, committed to performing ground-breaking research in the field of epigenetics. These groups are pioneers in their respective disciplines, utilizing cutting edge techniques to answer the complex questions of today.

The topics studied by the community include: stem cells, cellular plasticity, metabolism, diabetes, computational biology, epidemiology, immunology, development, and systems biology. 

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Epigenetics in Numbers

28
Research Groups
16
Institutes
6
Departments

Key Activities

News & Highlights

See all
When Metabolism Meets Chromatin: Histone Acylations Tune Gene Expression

IFE,

When Metabolism Meets Chromatin: Histone Acylations Tune Gene Expression

Metabolic dysfunction is a hallmark of numerous diseases, including diabetes and other metabolic disorders. But how do changes in our metabolism affect our cells and the way they function? How do they influence our genes?

The DNA is packaged into chromatin

IES, IFE,

Empowering Young Scientists: Applications Open for 2026 Chromatin Summer School

Talented PhD students are encouraged to apply for the upcoming Chromatin Summer School taking place from 17 - 29 August 2026

Verleihung des Bayerischen Maximiliansordens

Awards & Grants, Stem Cells, IES,

Maria-Elena Torres-Padilla Honored With the Maximiliansorden

Prof. Maria-Elena Torres-Padilla, this year’s Leibniz Prize winner, has received the Bavarian Maximiliansorden for Science and Art. Minister-President Dr. Markus Söder presented the distinguished state honor to her at the State Chancellery,…

Talent Forum Welcome

Events, Stem Cells, IES,

A Platform for Emerging Talent: The Helmholtz Munich Talent Forum 2025

The Helmholtz Munich Talent Forum took place on November 18–19, 2025, at the Helmholtz Munich Conference Center, bringing together eight outstanding early-career scientists from around the world working in the fields of Epigenetics and Nucleic Acids…

Exhibition Stem Cells at Deutsches Museum_For Website

Events, Stem Cells, IES, Molecular Targets and Therapeutics, IFE,

Exhibition on Cell Identity at the Deutsches Museum

How do the many different cells in the human body emerge from a single stem cell – and what makes each one unique? The Epigenetics Community at Helmholtz Munich explores these questions in a special exhibition at the Deutsches Museum. From 14. to 16.…

July 2025 GRC Conference Italy - Group photo

IFE,

GRC “Histone and DNA modifications” 2025 organised by Robert Schneider

The 2025 Gordon Research Conference (GRC) "Histone and DNA modifications" conference was organized by Robert Schneider from the Institute for Functional Epigenetics (IFE) at Helmholtz Munich

Businessmen shaking hands to seal a deal with his partner. Business and entrepreneurship award ceremony theme.

Recent Publications

Mol. Cell 86, 24-40.e10 (2026)

Nitsch, S. ; Coraor, A.E. ; Schauer, T. ; Wu, Y. ; Sun, J. ; Möritz, N. ; Funke, J.J. ; Nagpal, H. ; Chua, G.N.L. ; Battistini, F. ; Lauberth, S.M. ; Richard, E.M. ; Orozco, M. ; Liu, S. ; Desviat, L.R. ; Fierz, B. ; Dietz, H. ; Roeder, R.G. ; de Pablo, J.J. ; Schneider, R.

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.
Plant Sci. 362:112830 (2026)

Széles, E. ; Kondak, D. ; Da Silva, R.C. ; Szabados, L. ; Lindermayr, C. ; Kolbert, Z.

Genetic and bIOCHEMICAL approaches used FOR identification and MECHANISTIC characterization of NitriC oxide-RESPONSIVE plant genes.
In: (28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, 23-27 September 2025, Daejeon). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2026. 77-86 (Lect. Notes Comput. Sc. ; 15973 LNCS)

Dasdelen, M.F. ; Lim, H. ; Buck, M. ; Götze, K.S. ; Marr, C. ; Schneider, S.

CytoSAE: Interpretable Cell Embeddings for Hematology.
In: (28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, 23-27 September 2025, Daejeon). 2026. 445-455 (Lect. Notes Comput. Sc. ; 15963 LNCS)

Zedda, L. ; Loddo, A. ; Di Ruberto, C. ; Marr, C.

RedDino: A Foundation Model for Red Blood Cell Analysis.
In: (29th International Conference on Information Processing in Medical Imaging, IPMI 2025, 25-30 May 2025, Kos). 2026. 19-32 (Lect. Notes Comput. Sc. ; 15829 LNCS)

Yang, C. ; Deutges, M. ; Navab, N. ; Sadafi, A. ; Marr, C.

Hierarchical Neural Cellular Automata for Lightweight Microscopy Image Classification.
Network syst. med. 1, 4-19 (2025)

Henao, J. ; Kindt, A. ; Seegmüller, T. ; Foerster, K. ; Flemmer, A.W. ; Behr, J. ; Kneidinger, N. ; Frankenberger, M. ; Theis, F.J. ; Schubert, B. ; List, M. ; Hilgendorff, A.

Multi-omic signatures relate to the severity of pulmonary outcome in neonates traced into adult disease.
Cell Syst. 16:101200 (2025)

Moffitt, J.R. ; Li, M. ; Nie, Q. ; Kanemaru, K. ; Teichmann, S.A. ; Dar, D. ; Kagohara, L.T. ; Itzkovitz, S. ; Vento-Tormo, R. ; Yanai, I. ; Fertig, E.J. ; Theis, F.J.

What is the main bottleneck in deriving biological understanding from spatial transcriptomic profiling?
Nat. Methods, 30 (2025)

Heumos, L. ; Ji, Y. ; May, L. ; Green, T.D. ; Peidli, S. ; Zhang, X. ; Wu, X. ; Ostner, J. ; Schumacher, A. ; Hrovatin, K. ; Müller, M. ; Chong, F. ; Sturm, G. ; Tejada Lapuerta, A. ; Dann, E. ; Dong, M. ; Pinto, G. ; Bahrami, M. ; Gold, I. ; Rybakov, S. ; Namsaraeva, A. ; Moinfar, A.A. ; Zheng, Z. ; Roellin, E. ; Mekki, I.I ; Sander, C. ; Lotfollahi, M. ; Schiller, H.B. ; Theis, F.J.

Pertpy: An end-to-end framework for perturbation analysis.
Nat. Commun. 16:11334 (2025)

Oak, M.S. ; Stock, M. ; Janeva, A. ; Mezes, M. ; Hynes-Allen, A.M. ; Straub, T. ; Forné, I. ; Ettinger, A. ; Hamperl, S. ; Imhof, A. ; van den Ameele, J. ; Scialdone, A. ; Hörmanseder, E.

Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development.
Aging 17, 2902-2915 (2025)

Saad, R. ; Costeira, R. ; Matias-Garcia, P.R. ; Villicaña, S. ; Gieger, C. ; Suhre, K. ; Peters, A. ; Kastenmüller, G. ; Rodriguez-Mateos, A. ; Dias, C. ; Menni, C. ; Waldenberger, M. ; Bell, J.T.

Theobromine is associated with slower epigenetic ageing.
Nat. Commun. 16:11106 (2025)

Makris, K. ; Fonda, V. ; Ramadhani, F.F. ; Fadel, L. ; Davezac, M. ; Payet, B. ; Deligiannis, I.K. ; Zhang, L. ; Horn, T. ; Heimerl, L. ; Jouffe, C. ; Heddes, M. ; Martinez Jimenez, C.P. ; Quagliarini, F. ; Uhlenhaut, N.H.

Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms.
2025 in
In: (42nd International Conference on Machine Learning, ICML 2025, 13-19 July 2025, Vancouver). 2025. 47478-47508 ( ; 267)

Palma, A. ; Rybakov, S. ; Hetzel, L. ; Günnemann, S. ; Theis, F.J.

Enforcing Latent Euclidean Geometry in Single-Cell VAEs for Manifold Interpolation.
2025 in
In: (42nd International Conference on Machine Learning, ICML 2025, 13-19 July 2025, Vancouver). 2025. 61769-61789 ( ; 267)

von Kleist, H. ; Wendland, J.R. ; Shpitser, I. ; Marr, C.

Feature Importance Metrics in the Presence of Missing Data.
Mamm. Genome 37:10 (2025)

Ehlich, H. ; Blease, A. ; Biju, R. ; Gustems, M. ; Song, F. ; Fessele, S. ; Massimi, M. ; Bozonelos, K. ; Ntafis, V. ; Hiltunen, A.E. ; Marschall, S. ; Stoeger, C. ; Khorshidi, Z. ; Ziadi, A. ; Jambou, K. ; Armagno, A. ; Scavizzi, F. ; Raspa, M. ; Fernández, J. ; del Hierro, M.J. ; Ayadi, A. ; Pensavalle, J. ; Prevost, G. ; Dufkova, L. ; Krupkova, M. ; Nickl, P. ; Krimpenfort, P. ; Jonkers, J. ; Valera Vazquez, G. ; Raess, M. ; Beckers, J. ; Moles, A. ; Dahlhoff, M. ; Montoliu, L. ; Herault, Y. ; Hinttala, R. ; Kontoyiannis, D.L. ; Sedlacek, R. ; Hrabě de Angelis, M. ; Boersma, A.A. ; Matteoni, R.

A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.
Diabetes Care 49, 282-291 (2025)

Ge, J. ; Han, S. ; Shi, M. ; Harada, M. ; Yu, S. ; Zheng, J. ; Prehn, C. ; Adamski, J. ; Kastenmüller, G. ; Schlesinger, S. ; Koenig, W. ; Linkohr, B. ; Thorand, B. ; Suhre, K. ; Gieger, C. ; Peters, A. ; Wang-Sattler, R.

Integrative metabolomics of targeted and non-targeted analyses in T2D progression.

Padovani, F. ; Stegmaier, T. ; Mairhörmann, B. ; Schmoller, K.M.

Analysis of multidimensional microscopy data using cell-ACDC.
EMBO Rep. 26, 4691-4722 (2025)

Ummethum, H. ; Murriello, A.C. ; Werner, M. ; Márquez-Gómez, E. ; König, A.-C. ; Kruse, E. ; Lalonde, M. ; Trauner, M. ; Chanou, A. ; Weiß, M. ; Lee, C.S.K. ; Ettinger, A. ; Erhard, F. ; Hauck, S.M. ; Hamperl, S.

The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress.
Nucleic Acids Res. 54, D652-D660 (2025)

Türei, D. ; Schaul, J. ; Palacio-Escat, N. ; Bohár, B. ; Bai, Y. ; Ceccarelli, F. ; Çevrim, E. ; Daley, M. ; Darcan, M. ; Dimitrov, D. ; Dogan, T. ; Domingo-Fernández, D. ; Dugourd, A. ; Gábor, A. ; Gul, L. ; Hall, B.A. ; Hoyt, C.T. ; Ivanova, O. ; Klein, M. ; Lawrence, T. ; Mañanes, D. ; Módos, D. ; Müller-Dott, S. ; Ölbei, M. ; Schmidt, C. ; Şen, B. ; Theis, F.J. ; Ünlü, A. ; Ulusoy, E. ; Valdeolivas, A. ; Korcsmáros, T. ; Saez-Rodriguez, J.

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International Helmholtz-Edinburgh Research School for Epigenetics

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