Epigenetics@HelmholtzMunich
Dozens of researchers at Helmholtz Munich joined forces to reveal the myriad of secrets of Epigenetics.
Dozens of researchers @Helmholtz Munich join forces to reveal the myriad of secrets of Epigenetics.
Learn more about us below.
The Epigenetics@HelmholtzMunich Community Research consists of almost 30 labs from 17 Helmholtz Munich institutes, committed to performing ground-breaking research in the field of epigenetics. These groups are pioneers in their respective disciplines, utilizing cutting edge techniques to answer the complex questions of today.
The topics studied by the community include: stem cells, cellular plasticity, metabolism, diabetes, computational biology, epidemiology, immunology, development, and systems biology.
Epigenetics in Numbers
Key Activities
Our Groups
Seminars & Events
Recent Publications
Valla, L. ; Schwager, M.F. ; Cohrs, C.M. ; Stöckl, J.B. ; Karampelias, C. ; Shashikadze, B. ; Rathkolb, B. ; Lindner, R. ; Kraetzl, M. ; Renner, S. ; Molina van Den Bosch, M. ; Yang, K. ; Sterr, M. ; Böttcher, A. ; Hrabě de Angelis, M. ; Speier, S. ; Fröhlich, T. ; Theis, F.J. ; Lickert, H. ; Wolf, E. ; Kemter, E.
Pregestational maternal diabetes primes neonatal beta cell dysfunction with structural remodelling, impaired calcium buffering and altered mTORC2–Gαq–PKCα signalling in a pig model.Horstmann, H. ; Wolfram, C. ; De Vore, L. ; Abdelwahed, Y.S. ; Amend, A. ; Meteva, D. ; Heiser, M. ; Stapmanns, P. ; Seppelt, C. ; Zanders, L. ; Nelles, G. ; Peters, D. ; Wientjens, C. ; Zimmermann, F. ; Yücel, D. ; Franitza, M. ; Becker, K. ; Losert, C. ; Heinig, M. ; Stark, K. ; Joner, M. ; Lang, A. ; Riffelmacher, T. ; Gerdes, N. ; Baldus, S. ; Giannarelli, C. ; Wolf, D. ; Landmesser, U. ; Kränkel, N. ; Leistner, D.M. ; Winkels, H. ; Gerhardt, T.
Divergent T cell programs in plaque rupture and erosion revealed by single-cell multiomics in the OPTICO-ACS study.Basille, A. ; Bawadi, Y. ; Lin, Y. ; Kirke, C. ; Bourgeay, C. ; Cluet, D. ; Vachez, L. ; Dervieux, V. ; Guiguettaz, L. ; Bernard, P. ; Hamperl, S. ; Pasero, P. ; Ricci, E.P. ; Vanoosthuyse, V.
The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids.Kardoost, A. ; Ghanem, N. ; Li, T. ; Kolter, J. ; Marr, C.
A large-scale expert-annotated 3D image dataset of dermal tissue macrophages.Dasdelen, M.F. ; Ozlugedik, F. ; Looser, I. ; Umer, R.M. ; Pohlkamp, C. ; Marr, C.
Genetically Aligned Patient Representations Improve Hematological Diagnosis.Chadha, Y. ; Kukhtevich, I. ; Stegmaier, T. ; Padovani, F. ; Schneider, R. ; Schmoller, K.M.
Single-cell imaging reveals a key role of Bck2 in yeast cell size adaptation to nutrient challenges.Stępień, A. ; Pulimamidi, D. ; Plens-Gałąska, M. ; Lalonde, M. ; Kopczyńska, M. ; Ostatek, K. ; Kapeliukha, M. ; Kimurâ, H. ; Irshad, S. ; Gdula, M.R. ; Hamperl, S. ; Kamieniarz-Gdula, K.
Proximity of pre-mRNA 3′ end processing and transcription termination is associated with enhanced gene expression.Munoz-Barrera, M. ; Mata-Cabana, A. ; Moreno-Rivero, A. ; Piubeli, F.A. ; Ren-Barroso, B. ; Al-Refaie, N. ; Gutierrez, G. ; Cabianca, D.S. ; Olmedo, M.
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans.Grashei, C. ; Brechenmacher, C. ; Umer, R.M. ; Liu, J. ; Marr, C. ; Schüffler, P. ; Szczurek, E.
Pathryoshka: Compressing Pathology Foundation Models via Multi-teacher Knowledge Distillation with Nested Embeddings.Schütze, T.M. ; Kolodziejczyk, A. ; Ditzer, N. ; Vangelisti, S. ; Capra, E. ; Lee, J. ; Chiaradia, I. ; Kufrin, V. ; Yamada, S. ; Peters, J. ; Krause, M. ; Oegema, C.E. ; Derihaci, R.P. ; Birdir, C. ; Namba, T. ; Wurm, A.A. ; Martin, U. ; Wimberger, P. ; Long, K.R. ; Lancaster, M.A. ; Kalebic, N. ; Bonev, B. ; Albert, M.
Human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution.Riel, J. ; Singh, V.M. ; Aryasomayajula, S.A. ; Chinbat, A. ; Leonhard, H. ; Ladenburger, M. ; Alexander, F. ; Choudhary, V. ; Laredo, F. ; Masserdotti, G. ; Prein, T. ; Marr, C. ; Kardoost, A.
HASSL: Hierarchy-Aware Self-supervised Learning Framework for Single Cell Microscopy.Schmacke, N.A. ; Mädler, S.C. ; Wallmann, G. ; Metousis, A. ; Varlamova, V. ; Steigerwald, S. ; Christ, S.B. ; Bérouti, M. ; Harz, H. ; Leonhardt, H. ; Theis, F.J. ; Mann, M. ; Hornung, V.
SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening.Leonhardt, L. ; Mei, J. ; Hendley, A.M. ; Ansari, S.A. ; Ashe, S. ; Berrios, D.I. ; Joost, L.-H. ; Fadel, L. ; Yigin, M. ; Wirth, J. ; Lewandowski-Hoppe, N. ; Maachi, H. ; Schicktanz, F. ; Remke, M. ; Lindner, R. ; Li, L.Y. ; Gbenedio, O.M. ; Hui, Y. ; Ghabi, E. ; Luchini, C. ; Malleo, G. ; He, J. ; Graham, R.P. ; Roose, J.P. ; Dawson, D.W. ; Uhlenhaut, N.H. ; Feuchtinger, A. ; Steiger, K. ; Kim, G.E. ; Hebrok, M.
KDM6 histone demethylases tune pancreatic cancer plasticity.Hamad, S.G. ; Makhlouf, M. ; Agrebi, N. ; Kaddourah, A. ; Abu-Hasan, M. ; Al‐Adba, B. ; Sadoun, A. ; Hubrack, S.Z. ; Aamer, W. ; Ruiz Tejada Segura, M.L. ; Scialdone, A. ; Machaca, K. ; Saraiva, L.R. ; Bout-Tabaku, S. ; Lo, B.
Unraveling immune dysregulation in ZNFX1 deficiency: From interferonopathies to macrophage activation syndrome.Solovey, M. ; Celik, M.A. ; Salcher, F. ; Gülec, C. ; Abdalfattah, M. ; Ali, M.I.H ; Heinig, M. ; Scialdone, A. ; Ziemann, F. ; Colomé-Tatché, M.
Community: Component based differential cell communication analysis in large multi-sample case-control scRNAseq datasets.Lotfollahi, M. ; Bright, C. ; Skorobogat, R. ; Dehkordi, M.M. ; George, X. ; Richter, S. ; Shitov, V.A. ; Topalova, A. ; Melcher, H. ; Nussbaumer, N. ; Fomm, A. ; Luecken, M. ; Theis, F.J.
ArchMap is a web-based platform for reference-based analysis of single-cell datasets.Behr, R. ; Gallo-Franco, J.J. ; Hazarika, R.R. ; Zhang, Z. ; Wilming, F. ; Schnitzler, J.-P. ; Lindermayr, C. ; Johannes, F.
DNA methylome responses to biotic and abiotic stress in Arabidopsis thaliana: A multi-study analysis.Gogiraju, R. ; Moiko, K. ; Bochenek, M.L. ; Greulich, F. ; Witzler, C. ; Schmitz, W. ; Zifkos, K. ; Derieux, C. ; Ghasemi, I. ; Guliani, P. ; Sun, B. ; Espinola-Klein, C. ; Uhlenhaut, N.H. ; Bock, A. ; Ruf, W. ; Madhusudhan, T. ; Lurz, P. ; Schäfer, K.
Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis.