Institute of Metabolism and Cell Death
Publications
Read more2022 Scientific Article in Clinical Immunology
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis.
2022 Review in Deutsche Apotheker-Zeitung
Den „Eisen-Tod“ verhindern Bedeutung der antioxidativen Vitamine und der Vitamin-K-Familie.
2022 Scientific Article in Frontiers in Oncology
Glioblastoma relapses show increased markers of vulnerability to ferroptosis.
2022 Scientific Article in Journal of the American Chemical Society
Intrinsic and extrinsic limitations to the design and optimization of inhibitors of lipid peroxidation and associated cell death.
2022 Scientific Article in Nature
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
2022 Scientific Article in Molecular Metabolism
NFE2L1-mediated proteasome function protects from ferroptosis.
2022 Scientific Article in Molecular Psychiatry
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.
2022 Scientific Article in Nature Communications
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
2022 Scientific Article in Nature Communications
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death.
2022 Scientific Article in Nature Chemical Biology
Characterization of a patient-derived variant of GPX4 for precision therapy.
2021 Scientific Article in Cell Death & Disease
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
2021 Scientific Article in Redox Biology
Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4.
2021 Scientific Article in Redox Biology
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model.
2021 Scientific Article in Journal of Chinese Pharmaceutical Sciences
The research group of Guoquan Liu revealed that photodynamic therapy drove a distinct ferroptosis-like cell death pathway in tumor cells Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway.
2021 Scientific Article in Nitric oxide
Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.
2021 Scientific Article in Nature Cell Biology
Non-invasive and high-throughput interrogation of exon-specific isoform expression.
2021 Cell Research
Publisher Correction: Ferroptosis: The Good, the Bad and the Ugly (Cell Research, (2020), 30, 12, (1061-1062), 10.1038/s41422-020-00434-0).
2021 Scientific Article in Nature Communications
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
2021 Scientific Article in Cell Death & Disease
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.
2021 Scientific Article in Redox Biology
Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway.
2021 Review in Trends in Endocrinology and Metabolism
Juggling with lipids, a game of Russian roulette.
2021 Scientific Article in Nature Communications
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
2021 Review in Nature Reviews - Molecular Cell Biology
Ferroptosis: Mechanisms, biology and role in disease.
2021 Scientific Article in Biochimica et Biophysica Acta - Molecular Cell Research
Cathepsin B is an executioner of ferroptosis.
2021 Review in Trends in Molecular Medicine
Targeting ferroptosis: New hope for as-yet-incurable diseases.
2020 Review in Biological Chemistry
Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease.
2020 Scientific Article in Journal of Hepatology
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
2020 Scientific Article in International Journal of Cancer
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice.
2020 Scientific Article in eLife
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans.
2020 Review in Cell Chemical Biology
Selenium: Tracing another essential element of ferroptotic cell death.
2020 Scientific Article in Genes and Development
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling.
2020 Scientific Article in FASEB Journal
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
2020 Scientific Article in Haematologica - The Hematology Journal
Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.
2019 Meeting abstract in Transplant international
Role of ferroptosis and ischemia reperfusion injury in liver transplantations.
2019 Meeting abstract in Transplant international
Activation of innate immune cells by ferroptosis in hepatic ischemia reperfusion injury.
2019 Review in Nature Reviews - Cancer
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion.
2019 Scientific Article in Journal of Medicinal Chemistry
Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4.
2019 Review in Free Radical Biology and Medicine
Role of GPX4 in ferroptosis and its pharmacological implication.
2019 Review in Cell Death and Differentiation
Ferroptosis and necroinflammation, a yet poorly explored link.
2018 Scientific Article in Journal of the American Chemical Society
Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE.
2018 Meeting abstract in Transplant international
Innate immune cells are activated by regulated cell death events in early hepatic ischemia reperfusion injury.
2018 Meeting abstract in Swiss Medical Weekly
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell but not B-cell metabolic reprogramming and proliferation.
2018 Meeting abstract in Transplantation
Targeting innate immune cells and regulated cell death in early hepatic ischemia reperfusion injury.
2018 Scientific Article in Journal of Clinical Investigation
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
2018 Review in Genes and Development
Regulation of lipid peroxidation and ferroptosis in diverse species.
2018 Review in Frontiers in Neuroscience
Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system. .
2018 Scientific Article in Nature Communications
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.
2018 Scientific Article in Journal of the American Chemical Society
Quantitative profiling of protein carbonylations in ferroptosis by an aniline-derived probe.
2018 Review in Cell Death and Differentiation
Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018.
2018 Scientific Article in Scientific Reports
The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells.
2018 Scientific Article in Cell
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.
2018 Redox Biology
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017).
2017 Meeting abstract in Free Radical Biology and Medicine
Selenium utilization by GPX4 was an evolutionary requirement to prevent hydroperoxide-induced ferroptosis.
2017 Meeting abstract in Transplant international
Interaction of innate immune cells and regulated cell death in early hepatic ischemia reperfusion injury.
2017 Scientific Article in Cell
Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease.
2017 Scientific Article in Oxidative medicine and cellular longevity
Modulation of glutathione hemostasis by inhibition of 12/15-lipoxygenase prevents ROS-mediated cell death after hepatic ischemia and reperfusion.
2017 Meeting abstract in FASEB Journal
Tocopherols and tocotrienols prevent lipoxygenase-driven phospholipid oxidation in ferroptosis.
2017 Meeting abstract in Haematologica - The Hematology Journal
Lack of the ferroptosis inhibitor GPX4 in erythroid cells causes a block in reticulocyte maturation and a hypoxic signature with impaired hepcidin regulation.
2017 Scientific Article in Antioxidants & Redox Signaling
GPx4, lipid peroxidation, and cell death: Discoveries, rediscoveries, and open issues.
2017 Scientific Article in ACS central science
On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
2017 Review in Trends in Pharmacological Sciences
Ferroptosis inhibition: Mechanisms and opportunities.
2017 Scientific Article in Neuroscience
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
2017 Scientific Article in Scientific Reports
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
2017 Scientific Article in Nature Chemical Biology
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
2017 Scientific Article in Nature Chemical Biology
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
2016 Scientific Article in Nature Nanotechnology
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth.
2016 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology
Endothelial dysfunction, and a prothrombotic, proinflammatory phenotype is caused by loss of mitochondrial thioredoxin reductase in endothelium.
2016 Scientific Article in Scientific Reports
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness.
2016 Scientific Article in Redox Biology
Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
2016 Review in Nature Reviews - Drug Discovery
Regulated necrosis: Disease relevance and therapeutic opportunities.
2016 Scientific Article in PLoS Genetics
A glutathione-Nrf2-thioredoxin cross-talk ensures keratinocyte survival and efficient wound repair.
2016 Scientific Article in Cell Stem Cell
Identification and successful negotiation of a metabolic checkpoint in direct neuronal repogramming.
2016 Scientific Article in Brain: A Journal of Neurology
Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.
2015 Scientific Article in Molecular & Cellular Oncology
Glutathione peroxidase 4 (Gpx4) and ferroptosis: What's so special about it?
2015 Scientific Article in Journal of Biological Chemistry, The
Expression of a catalytically inactive mutant form of Glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility.
2015 Scientific Article in Free Radical Biology and Medicine
The antioxidant requirement for plasma membrane repair in skeletal muscle.
2015 Review in Biological Chemistry
Thiol switches in mitochondria: Operation and physiological relevance.
2015 Scientific Article in Antioxidants & Redox Signaling
Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.
2015 Scientific Article in Journal of Experimental Medicine
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.
2015 Scientific Article in Journal of Biological Chemistry, The
Cystathionine is a novel substrate of cystine/glutamate transporter: Implications for immune function.
2015 Scientific Article in Antioxidants & Redox Signaling
Cardiolipin signaling mechanisms: Collapse of asymmetry and oxidation.
2015 Review in Biochimica et Biophysica Acta - General Subjects
ROS, thiols and thiol-regulating systems in male gametogenesis.
2014 Meeting abstract in Free Radical Biology and Medicine
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in a therapeutically relevant mechanism.
2014 Scientific Article in Nature Cell Biology
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
2014 Scientific Article in Antioxidants & Redox Signaling
Phosphoinositide 3-kinases upregulate system xc - via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy.
2014 Scientific Article in Atherosclerosis
Induction of inducible Nitric Oxide Synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.
2014 Scientific Article in Cell Death & Disease
Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.
2014 Scientific Article in Biological Trace Element Research
Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons.
2013 Scientific Article in Chemical Research in Toxicology
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
2013 Scientific Article in Circulation Research
Combined deficiency in glutathione peroxidase 4 and vitamin E causes multi-organ thrombus formation and early death in mice.
2013 Scientific Article in Journal of Investigative Dermatology, The
Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.
2013 Review in Neurochemistry International
Glutathione and thioredoxin dependent systems in neurodegenerative disease: What can be learned from reverse genetics in mice.
2013 Scientific Article in Biochimica et Biophysica Acta - General Subjects
Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
2012 Scientific Article in Cell Death and Differentiation
ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling.
2012 Scientific Article in PLoS ONE
Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
2012 Scientific Article in Journal of Proteomics
Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation.
2012 Scientific Article in Journal of Cellular Physiology
The nuclear form of Glutathione Peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization.
2012 Scientific Article in Amino Acids
The oxidative stress-inducible cystine/glutamate antiporter, system xc-: Cystine supplier and beyond.
2011 Scientific Article in Circulation
Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.
2011 Scientific Article in Molecular Immunology
Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.
2011 Scientific Article in Proteomics
Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.
2011 Scientific Article in European Heart Journal
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
2011 Scientific Article in Journal of Andrology
Glutathione peroxidases (GPX) at work on epididymal spermatozoa: An example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.
2011 Scientific Article in FASEB Journal
Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild type selenoenzyme.
2011 Scientific Article in FASEB Journal
Dopaminergic neurons of system xc‾-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.
2011 Scientific Article in Cell Death and Differentiation
Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons.
2010 Scientific Article in Antioxidants & Redox Signaling
Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies.
2010 Scientific Article in Neoplasia : An International Journal for Oncology Research
Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.
2010 Scientific Article in Experimental Cell Research
Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin.
2010 Scientific Article in FASEB Journal
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.
2010 Scientific Article in Cancer Research
Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.
2010 Scientific Article in Journal of Biological Chemistry, The
System xc− and thioredoxin reductase 1 cooperatively rescue glutathione deficiency.
2009 Scientific Article in Stem Cells
EpCAM is involved in maintenance of the murine embryonic stem cell phenotype.
2009 Review in Biochimica et Biophysica Acta - General Subjects
Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.
2009 Scientific Article in FASEB Journal
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
2008 Scientific Article in Cell Metabolism
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-Mediated cell death.
2008 Scientific Article in Oncogene
The cystine/cysteine cycle: A redox cycle regulating susceptibility versus resistance to cell death.
2007 Scientific Article in Biological Chemistry
B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance.
2007 Scientific Article in Biological Chemistry
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.
2007 Scientific Article in Genesis : The Journal of Genetics and Development
Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate.
2006 Scientific Article in Gene Expression Patterns
Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase.
2005 Scientific Article in Molecular and Cellular Biology
Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation.
2005 Scientific Article in Molecular and Cellular Biology
The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.
2005 Scientific Article in Molecular and Cellular Biology
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development.
2004 Scientific Article in Molecular and Cellular Biology
Essential role for mitochondrial thioredoxin reductase in hematopoisis, heart development and heart function.
2003 Scientific Article in Biological Chemistry
Testis-Specific Expression of the Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx).
2003 Scientific Article in Diabetologia
IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.
2003 Scientific Article in BioTechniques / Protocol Guide