Aldrovandi Lab
Ferroptomics
“Using state-of-the-art ultrasensitive mass spectrometry-based technology, we aim to identify common ferroptotic signatures in pathological conditions relevant to ferroptosis."
Lipid peroxidation is the major molecular mechanism involved in oxidative damage of cellular membranes and in the toxic process that leads to a prevailing form of regulated cell death, known as ferroptosis. Our core research aim is to combine synthetic biology approaches, especially gene editing and phenotype engineering with system biology, such as (oxi-)lipidomic and metabolomic workflows, to map metabolic changes underlying the development of diseases related to ferroptosis and to identify ferroptotic-specific signatures with potential for biomarker development.
About our Research
“Using state-of-the-art ultrasensitive mass spectrometry-based technology, we aim to identify common ferroptotic signatures in pathological conditions relevant to ferroptosis."
Lipid peroxidation is the major molecular mechanism involved in oxidative damage of cellular membranes and in the toxic process that leads to a prevailing form of regulated cell death, known as ferroptosis. Our core research aim is to combine synthetic biology approaches, especially gene editing and phenotype engineering with system biology, such as (oxi-)lipidomic and metabolomic workflows, to map metabolic changes underlying the development of diseases related to ferroptosis and to identify ferroptotic-specific signatures with potential for biomarker development.
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