Prof. Dr. Jovica Ninkovic; Head of Research Unit Central Nervous System Research

Head of Research Unit Central Nervous System Research

Prof. Dr. Jovica Ninkovic

"I am committed to developing novel therapies for CNS damage caused by traumatic brain injury or brain cancer—devastating diseases with limited treatment—using innovative approaches grounded in glial biology and function."

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Academic Career and Research Areas

Prof. Jovica Ninkovic’s academic journey began with studies in Molecular Biology and Physiology at the University of Belgrade, followed by a Master’s degree in Molecular Genetics. He completed his doctoral research at the Technical University of Munich, where he investigated the molecular mechanisms of neurogenesis in zebrafish and established a strong foundation in developmental neuroscience. This early work ignited his enduring interest in how the central nervous system develops, adapts, and regenerates.

 

He continued his scientific career at the Helmholtz Zentrum Munich in the laboratory of Prof. Magdalena Götz, first as a postdoctoral researcher and later as a staff scientist, where he deepened his expertise in neural stem cells and glial biology. Since 2013, he has led the Neurogenesis and Regeneration Group, and since 2018 he has served as Professor of Anatomy at LMU Munich. Since 2025, he also leads the Research Unit “Central Nervous System Regeneration” within the Stem Cell Center at Helmholtz Zentrum Munich, further strengthening his role at the forefront of regenerative neuroscience.

 

His research aims to uncover the fundamental mechanisms that enable successful regeneration in the central nervous system. He has made seminal contributions to understanding how specific glial behaviors drive regenerative outcomes. His work has pioneered the use of single-cell and spatial transcriptomics to map glial responses with unprecedented resolution, revealing dynamic cellular states during regeneration. In addition, he has advanced the field by identifying key epigenomic changes that confer regenerative competence and by providing the first insights into environmental signals that promote successful repair. Together, these discoveries lay the groundwork for innovative therapeutic strategies to restore brain function after injury and disease.

Fields of Work and Expertise

CNS Regeneration Glial Biology Single-Cell Transcriptomics Epigenomic Regulation Regenerative Competence Traumatic Brain Injury Glioblastoma Neuroinflammation Cellular Reprogramming 

Professional Background

2008 - 2014

Staf Scientist, Institute of Stem Cell research, Helmholtz Munich, Germany

2014 - 2018

Group Leader Central Nervous System Regeneration, Institute of Stem Cell research, Helmholtz Munich, Germany

Since 2018

W2 Professor for Regeneration and Plasticity of CNS Anatomy Professor, Institute of Cell Biology and Anatomy, Biomedical Center of LMU, Munich, Germany

Since 2024

Director of the Research Unit Central Nervous System Regeneration, Helmholtz Munich, Germany

Where Does Our Research Lead?

Honors and Awards

  • 2010 - LMU/Scopus Neuroscience Award
  • 2006 - Promotionspreis, TU München (Best PhD Thesis)

Representative Publications

2024

Koupourtidou C, Schwarz V, Aliee H, Frerich S, Fischer-Sternjak J, Bocchi R, Simon-Ebert T, Dichgans M, Götz M, Theis F, Ninkovic J.

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex. This study identified a shared inflammatory glial signature across cell types, space, and time after brain injury. It revealed a unified framework of glial reactivity, redefining neuroinflammation as a coordinated and targetable program for regeneration.
2022

Zambusi A, Novoselc KT, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, Aschenbroich S, Silva L, Yazgili AS, van Bebber F, Schmid B, Möller G, Tritscher C, Stigloher C, Delbridge C, Sirko S, Günes ZI, Liebscher S, Schlegel J, Aliee H, Theis F, Meiners S, Kiebler M, Dormann D, Ninkovic J.

TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. This study uncovered a central role of TDP-43 condensates and lipid droplets in controlling microglial reactivity and regenerative responses after traumatic brain injury. It revealed a novel link between cellular metabolism, phase separation, and neuroinflammation, opening new avenues to modulate brain repair.
2015

Calzolari F, Michel J, Baumgart EV, Theis F, Götz M*, Ninkovic J.*

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone. This study revealed that adult neural stem cells undergo rapid clonal expansion but possess limited self-renewal capacity, challenging prevailing views of long-term stem cell maintenance. It redefined the dynamics of adult neurogenesis and reshaped our understanding of how the brain sustains regeneration.
2015

Barbosa JS, Sanchez-Gonzalez R, Di Giaimo R, Baumgart EV, Theis FJ, Götz M, Ninkovic J.

Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain. This study pioneered real-time in vivo imaging of adult neural stem cells, revealing how injury activates regenerative programs. It established a new paradigm for understanding—and ultimately harnessing—endogenous brain repair.

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