Epigenetics@HelmholtzMunich
Dozens of researchers at Helmholtz Munich joined forces to reveal the myriad of secrets of Epigenetics.
Dozens of researchers @Helmholtz Munich join forces to reveal the myriad of secrets of Epigenetics.
Learn more about us below.
The Epigenetics@HelmholtzMunich Community Research consists of almost 30 labs from 17 Helmholtz Munich institutes, committed to performing ground-breaking research in the field of epigenetics. These groups are pioneers in their respective disciplines, utilizing cutting edge techniques to answer the complex questions of today.
The topics studied by the community include: stem cells, cellular plasticity, metabolism, diabetes, computational biology, epidemiology, immunology, development, and systems biology.
Epigenetics in Numbers
Key Activities
Our Groups
Seminars & Events
Recent Publications
Grashei, C. ; Brechenmacher, C. ; Umer, R.M. ; Liu, J. ; Marr, C. ; Schüffler, P. ; Szczurek, E.
Pathryoshka: Compressing Pathology Foundation Models via Multi-teacher Knowledge Distillation with Nested Embeddings.Schütze, T.M. ; Kolodziejczyk, A. ; Ditzer, N. ; Vangelisti, S. ; Capra, E. ; Lee, J. ; Chiaradia, I. ; Kufrin, V. ; Yamada, S. ; Peters, J. ; Krause, M. ; Oegema, C.E. ; Derihaci, R.P. ; Birdir, C. ; Namba, T. ; Wurm, A.A. ; Martin, U. ; Wimberger, P. ; Long, K.R. ; Lancaster, M.A. ; Kalebic, N. ; Bonev, B. ; Albert, M.
Human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution.Riel, J. ; Singh, V.M. ; Aryasomayajula, S.A. ; Chinbat, A. ; Leonhard, H. ; Ladenburger, M. ; Alexander, F. ; Choudhary, V. ; Laredo, F. ; Masserdotti, G. ; Prein, T. ; Marr, C. ; Kardoost, A.
HASSL: Hierarchy-Aware Self-supervised Learning Framework for Single Cell Microscopy.Schmacke, N.A. ; Mädler, S.C. ; Wallmann, G. ; Metousis, A. ; Varlamova, V. ; Steigerwald, S. ; Christ, S.B. ; Bérouti, M. ; Harz, H. ; Leonhardt, H. ; Theis, F.J. ; Mann, M. ; Hornung, V.
SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening.Leonhardt, L. ; Mei, J. ; Hendley, A.M. ; Ansari, S.A. ; Ashe, S. ; Berrios, D.I. ; Joost, L.-H. ; Fadel, L. ; Yigin, M. ; Wirth, J. ; Lewandowski-Hoppe, N. ; Maachi, H. ; Schicktanz, F. ; Remke, M. ; Lindner, R. ; Li, L.Y. ; Gbenedio, O.M. ; Hui, Y. ; Ghabi, E. ; Luchini, C. ; Malleo, G. ; He, J. ; Graham, R.P. ; Roose, J.P. ; Dawson, D.W. ; Uhlenhaut, N.H. ; Feuchtinger, A. ; Steiger, K. ; Kim, G.E. ; Hebrok, M.
KDM6 histone demethylases tune pancreatic cancer plasticity.Hamad, S.G. ; Makhlouf, M. ; Agrebi, N. ; Kaddourah, A. ; Abu-Hasan, M. ; Al‐Adba, B. ; Sadoun, A. ; Hubrack, S.Z. ; Aamer, W. ; Ruiz Tejada Segura, M.L. ; Scialdone, A. ; Machaca, K. ; Saraiva, L.R. ; Bout-Tabaku, S. ; Lo, B.
Unraveling immune dysregulation in ZNFX1 deficiency: From interferonopathies to macrophage activation syndrome.Solovey, M. ; Celik, M.A. ; Salcher, F. ; Gülec, C. ; Abdalfattah, M. ; Ali, M.I.H ; Heinig, M. ; Scialdone, A. ; Ziemann, F. ; Colomé-Tatché, M.
Community: Component based differential cell communication analysis in large multi-sample case-control scRNAseq datasets.Lotfollahi, M. ; Bright, C. ; Skorobogat, R. ; Dehkordi, M.M. ; George, X. ; Richter, S. ; Shitov, V.A. ; Topalova, A. ; Melcher, H. ; Nussbaumer, N. ; Fomm, A. ; Luecken, M. ; Theis, F.J.
ArchMap is a web-based platform for reference-based analysis of single-cell datasets.Behr, R. ; Gallo-Franco, J.J. ; Hazarika, R.R. ; Zhang, Z. ; Wilming, F. ; Schnitzler, J.-P. ; Lindermayr, C. ; Johannes, F.
DNA methylome responses to biotic and abiotic stress in Arabidopsis thaliana: A multi-study analysis.Gogiraju, R. ; Moiko, K. ; Bochenek, M.L. ; Greulich, F. ; Witzler, C. ; Schmitz, W. ; Zifkos, K. ; Derieux, C. ; Ghasemi, I. ; Guliani, P. ; Sun, B. ; Espinola-Klein, C. ; Uhlenhaut, N.H. ; Bock, A. ; Ruf, W. ; Madhusudhan, T. ; Lurz, P. ; Schäfer, K.
Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis.Rizzo, F. ; Ben-Shem, A. ; Timmers, H.T.M. ; Bartke, T. ; Vincent, S.D. ; Tora, L.
Step-brothers in arms, SAGA and ATAC co-activator complexes, use different strategies.Gissler, M.C. ; Gu, X. ; van der Zalm, F.B.H. ; Horstmann, H. ; Dominguez, J. ; Siegel, P.M. ; Stallmann, D. ; von Zur Muehlen, C. ; Marchini, T. ; Döring, Y. ; Heinig, M. ; Westermann, D. ; Mokry, M. ; Wolf, D.
Transcriptomic profiling identifies tumor necrosis factor receptor-associated factor (TRAF)-5 expression in human atherosclerotic plaques as a predictor of future cardiovascular events.Bakhtiari, M. ; Elkjaer, M.L. ; Can, A.O. ; Theis, F.J. ; Oubounyt, M. ; Baumbach, J.
Clifti-GPT: Privacy-preserving federated fine-tuning and transferable inference of foundation models on clinical single-cell data.Dasdelen, M.F. ; Ozlugedik, F. ; Litinetskaya, A. ; Navab, N. ; Marr, C. ; Sadafi, A.
Remixing Embeddings for Patient Augmentation in Data Scarce Multiple Instance Learning.Gil Lozano, M. ; Simoes Fernandez, E. ; Wu, M. ; Wiedemann, T. ; Kwon, Y. ; Sekar, R. ; Morigny, P. ; Troullinaki, M. ; Merl-Pham, J. ; Buettner, M. ; Feuchtinger, A. ; Jouffe, C. ; Maida, A. ; Hass, D, ; Samaga, D. ; Wolff, G. ; Machado, J. ; Giroud, M. ; Klepac, K. ; Cummins, C.L. ; Rios Garcia, M. ; Weber, P. ; Zeigerer, A. ; Uhlenhaut, N.H. ; Szendroedi, J. ; Blüher, M. ; Herzig, S.
Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity.Zedda, L. ; Mura, D.A. ; Ruberto, C.D. ; Atzori, M. ; Dasdelen, M.F. ; Marr, C. ; Loddo, A.
QG-MIL: A Gated Transformer Aggregator for Domain-Agnostic Multiple Instance Learning in Medical Imaging.Adami, E. ; Kim, Y. ; Zheng, S.L. ; Shvetsov, N. ; Losert, C. ; Maatz, H. ; Barish, S. ; Venturini, G. ; Anguita, N.L. ; Shi, Q. ; Neyazi, M. ; Beyer, M. ; Wei, Q. ; Adam, A. ; Suresh, A. ; Reichart, D. ; Lindberg, E.L. ; Brown, K. ; Strohmenger, V. ; Saul, D. ; Gaertner, A. ; Lee, M. ; Mach, L. ; Robertus, J.L. ; Gorham, J. ; Haas, J. ; Liebig, L.A. ; Lippert, C. ; Meder, B. ; Myronova, A. ; Patone, G. ; Barnett, S.N. ; Ware, J.S. ; Robertis, F.D. ; Pantazis, A. ; Gummert, J. ; Viveiros, A. ; Chen, H. ; Ruiz‐Orera, J. ; Frey, N. ; McDonough, B. ; Mitchell, R.N. ; Padera, R.F. ; Day, S.M. ; Ho, C.Y. ; Lakdawala, N.K. ; Milting, H. ; Heinig, M. ; Oudit, G.Y. ; Noseda, M. ; Seidman, J.G. ; Hübner, N. ; Seidman, C.E.
The molecular landscape of hypertrophic cardiomyopathy across disease stages and genotypes.Schuhmacher, M. ; Gruber, C. ; Lang, C.M.R. ; Ruijpers, R.M.W. ; Mazneykova, L. ; Beinsteiner, B. ; Krus, A. ; Tremmel, B. ; Reinhardt, F. ; Kadletz, K. ; Ma, Z. ; Casalta, L. ; Cambra, J.M. ; Otify, D.Y. ; Balken, I. ; Hetzel, L. ; Merl-Pham, J. ; Dorn, T. ; Luchner, M. ; Bauersachs, L. ; Ganea, K. ; Wieser, N. ; Emrich, A. ; Yağmur, E. ; Rager, K. ; Sagindykova, G. ; Armbrust, N. ; Geilenkeuser, J. ; Westmeyer, G.G. ; Bećirović, E. ; Biel, M. ; Istvánffy, R. ; Weisenhorn, D.M. ; Truong, D.J.J. ; Theis, F.J. ; Ebert, G. ; Moretti, A. ; Ertürk, A. ; Bähr, A. ; Kupatt, C. ; Jasnin, M. ; Klymiuk, N. ; Giesert, F. ; Wurst, W.
Creating bottom-up RNA transfer vehicles from synthetic protein assemblies.