Helmholtz Diabetes Center

Helmholtz Institute for Metabolic, Obesity, and Vascular Research

The Helmholtz Institute for Metabolic, Obesity, and Vascular Research (Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung, HI-MAG) in Leipzig investigates molecular mechanisms linking adipose tissue dysfunction to metabolic and vascular diseases.

The Helmholtz Institute for Metabolic, Obesity, and Vascular Research (Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung, HI-MAG) in Leipzig investigates molecular mechanisms linking adipose tissue dysfunction to metabolic and vascular diseases.

Das rote Haus - Leipzig

About our Research

Take a look at our Metabolic Chambers:

Research Groups

Obesity overweight diabetes fitness abdomen adult background

Blüher Lab

Clinical Obesity Research

Illustration of human fat cells

Körner Lab

Childhood Obesity and Metabolic Research

Revaskularisation der Arteria femoralis superficialis

Steiner Lab

Applied Vascular Research

Adipocytes fats cells.

Massier Lab

Adipose Tissue Microarchitecture and Metabolism

Modell eines Gehirns mit Nervenzelle

Jais Lab

Diet-Induced Metabolic Alterations

Moleküle im Zellkern

Sheikh Lab

Vascular Epigenetics

Kristallstruktur von Vaspin

Heiker Lab

Molecular Obesity Research

Bioinformatics Core Unit

Our institute is supported by an expert group of bioinformaticians. Learn more about the people and their projects here.

Clinical Trial Unit

Our clinical studies are part of our Clinicial Trial Unit and carried out in cooperation with the Leipzig Medical Center. For further information, please click here.

Clinical Studies

many color bright candies on female tongue

OTB Study / The Obese Taste Bud Study

Study on the Changes in Taste Buds in Obesity

Kraft, Motivation

ValEE Study

Energy Balance and Its Influence on Energy Consumption - a Clinical Validation Study

übergewichtige junge frau trainiert mit hanteln

DOC WEIGHT 2.3 Study

Evaluation of the DOC WEIGHT® 2.3 Program for the Multimodal, Conservative Treatment of Obesity

Adorable Baby Boy with a measuring tape

CO-FU-Study / Childhood Obesity Follow-Up Study

Study on the Causes and Consequences of Obesity in Children, Adolescents and Yound Adults

Hand holding a paper sheet with transgender symbol

HHS-Study / Hormones and Health Study

Study on the Effects of the Hormones Estrogen and Testosterone on Eating Behavior, Metabolism, Sensory Function and the Cardiovascular System

Waage - Übergewicht 115kg

Leipzig Childhood Obesity Study

Leipzig Childhood Obesity Study - Severe Forms of Obesity

PeriPrevent Retro Study

PeriPrevent Retro Study

AdobeStock_139821288.jpeg

CONTENT-Study

Study on the Long-Term Effects of a Four-Year Obesity Therapy Programm

LOBB Logo_transparenter Hintergrund

LOBB / Leipzig Obesity BioBank

Leipzig Obesity BioBank

Closeup of a atherosclerosis- 3D rendering

Crack-it Study

Direct Comparison Between Lithotripsy-Based and Standard Lesion Preparation Using Balloon Angioplasty and Subsequent Supera Stent Implantation in Femoropopliteal Lesions with Severe Calcification

Research Female Scientist is using a Microscope and a Tablet Computer while Working in a Modern Laboratory. Doing Genetic and Pharmaceutical Researches.

Different Labs

Other clinical studies where HI-MAG scientists are involved

HI-MAG News

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MA-Foto Lucas Massier 01.2025

HI-MAG,

HI-MAG Group Leader Dr. Lucas Massier featured on Podcast "Forschungsquartett"

Dr. Lucas Massier was recently featured on the "Forschungsquartett" podcast by detektor.fm, where he discussed his research group's ("Adipose Tissue Microarchitecture and Metabolism") latest work on the functional specialization of fat cells (podcast…

Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, close-up view of cells.

HI-MAG,

Myoglobin Identified as a Key Regulator of the Body’s Energy-Burning Fat

Researchers at Helmholtz Munich have discovered that myoglobin, a protein traditionally associated with oxygen storage in muscle, also plays an essential role in thermogenic fat. Led by PD Dr. John Heiker and Christian Strehlau from the Helmholtz…

Collage: Die Gewinnerinnen des Posterpreises beim LRF 2026

HI-MAG,

Three HI-MAG Doctoral Researchers won Research Prizes at the 19th Leipzig Research Festival

Doctoral Researchers Asma Saidi, Helen Broghammer and Bárbara Dumrauf won Research Prizes in different categories at the 19th Leipzig Research Festival of Life Sciences. The festival took place on June 18th, 2026 at the Max-Bürger-Forschungszentrum…

Antje Körner Portait standing in nature

Awards & Grants, Diabetes, HI-MAG,

Antje Körner Receives Prestigious International Award for Research on Childhood Obesity

A major international distinction for Leipzig-based obesity research: Prof. Antje Körner has been awarded the Willendorf Award by the World Obesity Federation.

Mitarbeiterin-/PI-Foto Antje Körner

Awards & Grants, Diabetes, HI-MAG,

Antje Körner Elected to the Saxon Academy of Sciences and Humanities in Leipzig

Physician and researcher Prof. Antje Körner has been elected as a new member of the Saxon Academy of Sciences and Humanities in Leipzig. On April 10, 2026, she was officially admitted to the Academy’s Mathematical and Natural Sciences Class during…

Posterpreisverleihung AngioDynmaics Life Symposium 2026
Gewinnerin: Birte Winther (links)
rechts: Tim Wittig

HI-MAG,

Birte Winther received the Young Investigator’s Poster Award at the 9th AngioDynamics International LIFE Symposium

Birte Winther, Clinician Scientist at HI-MAG, received the Young Investigator’s Poster Award at the 9th AngioDynamics International LIFE Symposium. As one of three invited finalists, she was awarded the first place for her presentation about the…

Nurse and patient in hospital bed with medical monitors

Transfer, Diabetes, HI-MAG,

Translation: Where Medical Research Reaches People

How can we bring new scientific insights to patients more quickly? At Helmholtz Munich, we work hand in hand with leading clinics across Germany to translate research findings directly and purposefully into new therapeutic approaches — and,…

Center Template, Icon, Featured Publication, Diabetes

Featured Publication, Diabetes, HI-MAG,

Cholesterol-Lowering Drug Found to Target Key Metabolic Switch

Cardiovascular diseases are the leading cause of death worldwide, and lowering blood lipids is a central strategy to reduce risk. Bempedoic acid, a recently approved cholesterol-lowering drug, has now been shown by researchers at Helmholtz Munich to…

People @ HI-MAG

Alle ansehen
PI-/MA-Bilder Matthias Blüher_EH6A7638_Hintergrund freigestellt
Prof. Dr. Matthias Blüher

Director of the Helmholtz Institute for Metabolic, Obesity and Vascular Research and Head of Research Group Clinical Obesity Research, HI-MAG

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MA-Foto Konstanze Julich-Gruner_E6A8082_Hintergrund freigestellt
Dr. Konstanze Julich-Gruner

HI-MAG Institute's Manager

Mitarbeiterin-/PI-Foto Antje Körner
Prof. Dr. Antje Körner

Head of Childhood Obesity & Metabolic Research Group, HI-MAG

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IMG_E0229_Zuschnitt_Sabine Steiner
Prof. Dr. Sabine Steiner

Head of Applied Vascular Research Group, HI-MAG

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MA-Foto John Heiker_freigestellt
PD Dr. Dr. John Heiker

Group Leader of Molecular Obesity Research, HI-MAG

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Dr. Alexander Jais

Group Leader of Diet-Induced Metabolic Alterations, HI-MAG

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MA-Foto_Bilal Sheikh_DSCF6803_10.24 -  freigestellt
Dr. Bilal Sheikh

Group Leader of Vascular Epigenetics, HI-MAG

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MA-Foto Lucas Massier 01.2025 - freigestellt
Dr. Lucas Massier

Group Leader of Adipose Tissue Microarchitecture and Metabolism, HI-MAG

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Publications of HI-MAG

Front. Endocrin. 17:1804956 (2026)

Schurfeld, R. ; Baalmann, F. ; Baratashvili, E. ; Sandner, B. ; Bachmann, A. ; Weiner, J. ; Wurfel, M. ; Wendt, R. ; Haussmann, M. ; Bast, I. ; Beige, J. ; Kosacka, J. ; Klöting-Blüher, N. ; Krohn, K. ; Kirsten, T. ; Zhang, M. ; Harris, R.C. ; Isermann, B. ; Kovacs, P. ; Blüher, M. ; Stumvoll, M. ; Tonjes, A. ; Heiker, J.T. ; Ebert, T.

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease.
Obesity 34, 1635-1646 (2026)

Goergen, A. ; Challa, T.D. ; Villaroel‐Vicente, C. ; Borsigova, M. ; Krieken, P.P.v. ; Wolfrum, C. ; Blüher, M. ; Wueest, S. ; Konrad, D.

ASK1 ‐induced FGF21 synthesis in the liver Ppevents obesity in mice.
Front. Glob. Womens Health 7:1833913 (2026)

Galia, S. ; Crescenzi, R. ; Kruppa, P. ; Kartt, J. ; Cochrane, J.C. ; Mascio, C. ; Harmacek, L. ; Heil, S. ; Samouhos, E. ; Peterson, S. ; Dean, S.M. ; Wright, T.F. ; Cifarelli, V. ; Padera, T.P. ; Rutkowski, J.M. ; Eddens, K.S. ; Egan, C. ; Whitehead, S. ; Herbst, K.L. ; Bunnell, B.A. ; Shawber, C. ; Hucho, T. ; Hinyard, L. ; Al-Ghadban, S. ; Scott, A.O. ; Ostergaard, P. ; Pittman, A. ; Nono Nankam, P.A. ; Scherer, P.E. ; Forner-Cordero, I. ; Damstra, R.J. ; Hendrickx, A. ; Srinivasan, A.

The lipedema common case report form as a research tool: Standardizing lipedema data collection.
Innere Med. 67, 869–881 (2026)

Blüher, M. ; Bojunga, J. ; Fassnacht, M. ; Führer-Sakel, D.

Neuigkeiten aus Endokrinologie/Diabetologie.

Strehlau, C. ; Broghammer, H. ; Gebhardt, C. ; Hoffmann, A. ; Hagemann, T. ; Midilli, S. ; Zimmer, R.S. ; Schubert, K. ; Karagiannakou, V. ; Georgiadi, A. ; Ost, M. ; Krüger, M. ; Roth, L. ; Krause, K. ; Klöting-Blüher, N. ; Keller, M. ; Wabitsch, M. ; Nuwayhid, R. ; Stimson, R.H. ; Stumvoll, M. ; Blüher, M. ; Weiner, J. ; Heiker, J.T.

Adipocyte myoglobin is a determinant of energy expenditure and a potential target to limit obesity.
Transl. Psychiatry 16:318 (2026)

Oliveira, F. ; Papa, C. ; Hagemann, T. ; Schipper, R. ; Geier, F. ; Röxe, T. ; Zulfqar, F. ; Prönnecke, C. ; Schmidt, L. ; Stryhanyuk, H. ; Hoffmann, A. ; Kyselova, A. ; Karantanou, C. ; Buckley. Y. ; Farhan, M.A. ; Rodriguez Aguilera, J.R. ; Ambreen, S. ; Rodríguez-Aguilera, J.R. ; Arif, A. ; Martin, H.N.G. ; Ebert, T. ; Klöting-Blüher, N. ; Blüher, M. ; Shahzad, K. ; Boeckel, J.N. ; Hagberg, C.E. ; Chakaroun, R. ; Bibli, S.I. ; Sheikh, B.N.

Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation.
Clin. Epigenet. 18:118 (2026)

Ruf, S. ; Hoffmann, A. ; Müller, L. ; Landgraf, K. ; Vogel, M. ; Jørsboe, E. ; Kubitz, P. ; Dietrich, A. ; Ghosh, A. ; Noé, F. ; Wolfrum, C. ; Claussnitzer, M. ; Hauner, H. ; Stumvoll, M. ; Baber, R. ; Blüher, M. ; Körner, A. ; Kovacs, P. ; Keller, M.

Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: A multi-cohort study.
Clin. Oral Investig. 30:254 (2026)

Stiller, N. ; Schmidt, J. ; Meigen, C. ; Messerschmidt, A. ; Kiess, W. ; Vogel, M. ; Körner, A. ; Schulz-Kornas, E. ; Haak, R.

Remote assessment of caries, MIH, and plaque on intraoral 3D scan images: Findings from the LIFE Child study.

Kabbani, N. ; Ebert, T. ; Stepan, H. ; Lia, M. ; Blüher, M. ; Baber, R. ; Vogel, M. ; Biemann, R. ; Kiess, W. ; Tonjes, A. ; Schrey-Petersen, S.

Targeted proteomics reveal association between maternal biomarkers and child body weight in the first year of life.

Contact

informationszeichen
HI-MAG Office

Leipzig

Networks

Logo der Universität Leipzig seit 2017

Leipzig University

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Logo des Universitätsklinikum Leipzig

University of Leipzig Medical Center

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Leipzig Center of Metabolism (LeiCeM)

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European Association for the Study of Diabetes

European Association for the Study of Diabetes (EASD)

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Logo der Deutschen Diabetes Gesellschaft (DDG)

German Diabetes Association (Deutsche Diabetes Gesellschaft DDG)

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Logo des Helmholtz Zentrums für Umweltforschung Leipzig (UFZ)

Helmholtz Zentrum für Umweltforschung (UFZ)

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Logo Ben-Gurion-University

Ben-Gurion University of the Negev

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Karolinska Institutet

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DZKJ Logo Horizontal Deutsch; Deutsches Zentrum für Kinder- und Jugendgesundheit

German Center for Child and Adolescent Health (DZKJ)

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