All Complex Diseases Publications
2025 Scientific Article in European Journal of Cancer Eur. J. Cancer 214:115138 (2025)
Small-RNA sequencing reveals potential serum biomarkers for gallbladder cancer: Results from a three-stage collaborative study of large European prospective cohorts.
2025 Scientific Article in Diabetes, Obesity and Metabolism Diabetes Obes. Metab. 27, 338–347 (2025)
Subphenotypes of adult-onset diabetes: Data-driven clustering in the population-based KORA cohort.
2024 Scientific Article in Cancers Cancers 16:4195 (2024)
Inbreeding and gallbladder cancer risk: Homozygosity associations adjusted for indigenous american ancestry, BMI, and genetic risk of gallstone disease.
2024 Scientific Article in Communications Medicine Commun. Med. 4:265 (2024)
Interpretable multimodal machine learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy.
2024 Scientific Article in Aging Cell Aging Cell:e14431 (2024)
Tissue-specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:149 (2024)
Association analysis between an epigenetic alcohol risk score and blood pressure.
2024 Scientific Article in Journal of the American Heart Association J. Am. Heart Assoc. 13:e034760 (2024)
Genome-wide interaction analyses of serum calcium on ventricular repolarization time in 125 393 participants.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadl4374 (2024)
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Scientific Article in Biomolecules Biomolecules 14:662 (2024)
Smoking-induced DNA hydroxymethylation signature is less pronounced than true DNA methylation: The population-based KORA Fit cohort
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:181 (2024)
Plasma proteome association with coronary heart disease and carotid intima media thickness: Results from the KORA F4 study.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 778-791 (2024)
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
2024 Scientific Article in Nature Nature 628, 130-138 (2024)
Genome-wide characterization of circulating metabolic biomarkers.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:29 (2024)
Epigenome-wide association study of dietary fatty acid intake.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2359 (2024)
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets.
2024 Scientific Article in Nature Communications Nat. Commun. 15:888 (2024)
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
2024 Scientific Article in Frontiers in Nutrition Front. Nutr. 10:1295078 (2024)
Usual dietary intake and change in DNA methylation over years: EWAS in KORA FF4 and KORA fit.
2024 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank. 22, 110-114 (2024)
Effects of repeated freeze and thaw cycles on the genome-wide DNA methylation profile of isolated genomic DNA.
2023 Scientific Article in Nature human behaviour Nat. Hum. Behav. 7, 790-801 (2023)
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
2023 Scientific Article in Clinical Epigenetics Clin. Epigenet. 15:166 (2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
2023 Scientific Article in Frontiers in Genetics Front. Genet. 14:1235337 (2023)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
2023 Scientific Article in Nature Aging Nature Aging 3, 450-458 (2023)
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.
2023 Scientific Article in International Journal of Cancer Int. J. Cancer 153, 1151-1161 (2023)
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country.
2023 Scientific Article in Epigenetics Epigenetics 18:2211361 (2023)
Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.
2023 Scientific Article in Movement Disorders Mov. Disord. 38, 1410-1418 (2023)
Epigenetic association analyses and risk prediction of RLS.
2023 Scientific Article in Cancers Cancers 15:17 (2023)
Gallbladder cancer risk and indigenous South American Mapuche ancestry : Instrumental variable analysis using ancestry-informative markers.
2023 Scientific Article in Nature Communications Nat. Commun. 14:4646 (2023)
Genetic insights into resting heart rate and its role in cardiovascular disease.
2023 Scientific Article in Environment International Environ. Int. 178:108109 (2023)
Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration.
2023 Scientific Article in Molecular Psychiatry Mol. Psychiatry 28, 3874-3887 (2023)
Circulating metabolites modulated by diet are associated with depression.
2023 Scientific Article in Thyroid Thyroid 33, 301-311 (2023)
Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9.
2023 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 24:180 (2023)
G Protein-coupled receptor 15 expression is associated with myocardial infarction.
2022 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 62, 1357-1375 (2022)
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
2022 Scientific Article in Environmental Science & Technology Environ. Sci. Technol. 56, 17815-17824 (2022)
Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.
2022 Scientific Article in Genome Medicine Genome Med. 14:125 (2022)
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022 Scientific Article in Epigenomics Epigenomics 14, 1105-1124 (2022)
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.
2022 Scientific Article in Metabolites Metabolites 12:992 (2022)
Cluster analysis statistical spectroscopy for the identification of metabolites in 1H NMR metabolomics.
2022 Scientific Article in BMC Medical Genomics BMC Med. Genomics 15:124 (2022)
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.
2022 Scientific Article in Nature Communications Nat. Commun. 13:5144 (2022)
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.
2022 Scientific Article in Clinical Epigenetics Clin. Epigenet. 14:114 (2022)
DNA methylation and aeroallergen sensitization: The chicken or the egg?
2022 Scientific Article in Nature Communications Nat. Commun. 13:5198 (2022)
Identification of risk loci for primary aldosteronism in genome-wide association studies.
2022 Scientific Article in Nature Communications Nat. Commun. 13:5269 (2022)
Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
2022 Scientific Article in Clinical Epigenetics Clin. Epigenet. 14:83 (2022)
Longitudinal associations of DNA methylation and sleep in children: A meta-analysis.
2022 Scientific Article in Aging Aging 14, 5620-5627 (2022)
Common electrocardiogram measures are not associated with telomere length.
2022 Scientific Article in Life Life 12:1064 (2022)
Association between usual dietary intake of food groups and DNA methylation and effect modification by metabotype in the KORA FF4 cohort.
2022 Scientific Article in Clinical Epigenetics Clin. Epigenet. 14:87 (2022)
Maternal-fetal stress and DNA methylation signatures in neonatal saliva: An epigenome-wide association study.
2022 Review in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 66:e2200077 (2022)
Genetics and epigenetics in personalized nutrition: Evidence, expectations, and experiences.
2022 Scientific Article in Kidney International Kidney Int. 102, 624-639 (2022)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 3566-3579 (2022)
Genetic and clinical determinants of abdominal aortic diameter: Genome-wide association studies, exome array data and Mendelian randomization study.
2022 Scientific Article in Environmental Research Environ. Res. 212:113360 (2022)
Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults.
2022 Scientific Article in Communications Biology Comm. Biol. 5:580 (2022)
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
2022 Scientific Article in Journals of Gerontology Series A: Biological Sciences and Medical Sciences J. Gerontol. A Biol. Sci. Med. Sci. 77, 1750-1759 (2022)
The role of epigenetic clocks in explaining educational inequalities in mortality: A multi-cohort study and meta-analysis.
2022 Scientific Article in Aging Cell Aging Cell:e13608 (2022)
Integrative analysis of clinical and epigenetic biomarkers of mortality.
2022 Review in Current neuropharmacology Curr. Neuropharmacol. 20, 94-106 (2022)
Early biomarkers and intervention programs for the infant exposed to prenatal stress.
2022 Scientific Article in Nature Communications Nat. Commun. 13:2408 (2022)
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
2022 Scientific Article in eLife eLife 11:e71802 (2022)
Epigenetic scores for the circulating proteome as tools for disease prediction.
2022 Scientific Article in Cancers Cancers 14:634 (2022)
Identification of circulating lncRNAs associated with gallbladder cancer risk by tissue-based preselection, cis-eQTL validation, and analysis of association with genotype-based expression.
2022 Scientific Article in Allergy Allergy 77, 2803–2817 (2022)
Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 18–29 (2022)
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 1171-1182 (2022)
Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues.
2022 Scientific Article in Nephrology Dialysis Transplantation Nephrol. Dial. Transplant. 37, 1916-1926 (2022)
Novel biomarkers of inflammation, kidney function and chronic kidney disease in the general population.
2021 Scientific Article in Nature Communications Nat. Commun. 12:7174 (2021)
Meta-analyses identify DNA methylation associated with kidney function and damage.
2021 Scientific Article in Nature Communications Nat. Commun. 12:7173 (2021)
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:198 (2021)
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood.
2021 Scientific Article in Brain: A Journal of Neurology Brain, DOI: 10.1093/brain/awab360 (2021)
Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:195 (2021)
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: An EWAS in multi-ethnic Asian individuals.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 1717-1730 (2021)
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
2021 Scientific Article in PLoS Medicine PLoS Med. 18:e1003786 (2021)
The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.
2021 Scientific Article in Environmental epidemiology Environ. Epi. 5:e162 (2021)
Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease: The EU EXPANSE project.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:143 (2021)
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs.
2021 Scientific Article in Genome Biology Genome Biol. 22:194 (2021)
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
2021 Nature Communications Nat. Commun. 12:4256 (2021)
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:121 (2021)
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
2021 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol. 36, 1143-1155 (2021)
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
2021 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 32, 1747-1763 (2021)
Plasma proteomics of renal function: A trans-ethnic metaanalysis and Mendelian randomization study.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3987 (2021)
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 20:111 (2021)
Metabolic syndrome and the plasma proteome: From association to causation.
2021 Scientific Article in Nature Communications Nat. Commun. 12:2830 (2021)
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.
2021 Scientific Article in Genome Biology Genome Biol. 22:152 (2021)
On the optimistic performance evaluation of newly introduced bioinformatic methods.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 6293-6304 (2021)
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
2021 Scientific Article in Royal Society Open Science R. Soc. Open Sci. 8:201925 (2021)
The multiplicity of analysis strategies jeopardizes replicability: Lessons learned across disciplines.
2021 Scientific Article in Diabetes Diabetes 70, 1198-1208 (2021)
Differences in biomarkers of inflammation between novel subgroups of recent-onset diabetes.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:9203 (2021)
Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health.
2021 Scientific Article in Human Genetics and Genomics Advances HGG Advances 2:100013 (2021)
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits.
2021 Nature Communications Nat. Commun. 12:995 (2021)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in European Heart Journal Eur. Heart J. 42, 2000-2011 (2021)
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:60 (2021)
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases.
2021 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 30, 393-409 (2021)
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
2021 Scientific Article in Nature Communications Nat. Commun. 12:24 (2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1279 (2021)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:7 (2021)
DNA methylation and lipid metabolism: An EWAS of 226 metabolic measures.
2021 Scientific Article in Kidney International Kidney Int. 99, 926-939 (2021)
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
2021 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 22:bbaa230 (2021)
Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data.
2021 Scientific Article in Hepatology Hepatology 73, 2293-2310 (2021)
Epigenome-wide analysis of methylation changes in the sequence of gallstone disease, dysplasia, and gallbladder cancer.
2021 Scientific Article in Hepatology Hepatology 73, 1783-1796 (2021)
Gallstones, body mass index, C-reactive protein and gallbladder cancer—Mendelian randomization analysis of chilean and European genotype data.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2021 Scientific Article in Nutrients Nutrients 13:131 (2021)
Long-chain polyunsaturated fatty acids, homocysteine at birth and fatty acid desaturase gene cluster polymorphisms are associated with children’s processing speed up to age 9 years.
2021 Scientific Article in JAMA cardiology JAMA Cardiol. 6, 587-592 (2021)
Association of circulating monocyte chemoattractant protein-1 levels with cardiovascular mortality: A meta-analysis of population-based studies.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 2111–2125 (2021)
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
2021 Scientific Article in Addiction Biology Addict. Biol. 26:e12855 (2021)
Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data.
2020 Meeting abstract in European Journal of Human Genetics Eur. J. Hum. Genet. 28, 754-754 (2020)
Association between prenatal stress and infant DNA methylation.
2020 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 13, 387-395 (2020)
Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation.
2020 Scientific Article in PLoS Genetics PLoS Genet. 16:e1008718 (2020)
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
2020 Scientific Article in Clinical Epigenetics Clin. Epigenet. 12:157 (2020)
Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits.
2020 Scientific Article in Translational Psychiatry Transl. Psychiatry 10:323 (2020)
Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: Results from two longitudinal cohort studies.
2020 Scientific Article in Diabetes Diabetes 69, 2766-2778 (2020)
Deciphering the plasma proteome of type 2 diabetes.
2020 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 13:e002766 (2020)
Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality.
2020 Scientific Article in Aging Aging 12, 16539-16554 (2020)
Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies.
2020 Scientific Article in Aging Aging 12, 14092-14124 (2020)
Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals.
2020 Scientific Article in Nature Communications Nat. Commun. 11:2542 (2020)
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
2020 Scientific Article in Nutrients Nutrients 12:1470 (2020)
Metabolites, nutrients, and lifestyle factors in relation to coffee consumption: An environment-wide association study.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0232073 (2020)
A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.
2020 Meeting abstract in Reproductive Sciences Reprod. Sci. 27, 324A-324A (2020)
Non-invasive biophysical and epigenetic biomarkers of prenatal stress in a human cohort: FELICITy study.
2020 Scientific Article in Diabetes Care Diabetes Care 43, 875-884 (2020)
Epigenetic link between statin therapy and type 2 diabetes.
2020 Scientific Article in Cancer epidemiology Cancer Epidemiol. 65:101643 (2020)
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.
2020 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 16:e1007616 (2020)
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0227648 (2020)
Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples.
2020 Scientific Article in Nature Communications Nat. Commun. 11:15 (2020)
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
2020 Scientific Article in International Journal of Cancer Int. J. Cancer 146, 2648–2650 (2020)
Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data.
2020 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 145, 1208-1218 (2020)
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
2020 Scientific Article in Annals of Human Genetics Ann. Hum. Genet. 84, 195-200 (2020)
MTF1 binds to metal-responsive element e within the ATP7B promoter and is a strong candidate in regulating the ATP7B expression.
2019 Scientific Article in Neurology Neurology 92, e486-e503 (2019)
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.
2019 Scientific Article in Nature Communications Nat. Commun. 10:5121 (2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
2019 Scientific Article in Nature Communications Nat. Commun. 10:4957 (2019)
Associations of autozygosity with a broad range of human phenotypes.
2019 Scientific Article in British Journal of Nutrition Br. J. Nutr. 122, S68-S79 (2019)
Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells' glycerophospholipids in school-age children.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 1459-1474 (2019)
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
2019 Scientific Article in Nature Communications Nat. Commun. 10:4130 (2019)
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
2019 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol. 34, 1055-1074 (2019)
Validated inference of smoking habits from blood with a finite DNA methylation marker set.
2019 Scientific Article in Epigenomics Epigenomics 11, 1487-1500 (2019)
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.
2019 Meeting abstract in Allergy Allergy 74, 129-129 (2019)
Pathway analysis-Genetic and immunological influences of gene polymorphisms in 17q21 locus on childhood wheeze.
2019 Review in Annual review of nutrition Ann. Rev. Nutr. 39, 21-44 (2019)
FADS1 and FADS2 polymorphisms Mmdulate fatty acid metabolism and dietary impact on health.
2019 Scientific Article in Nature Communications Nat. Commun. 10:3346 (2019)
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:8887 (2019)
Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes.
2019 Scientific Article in Environment International Environ. Int. 132:104723 (2019)
Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation.
2019 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 73, 3118-3131 (2019)
Effects of calcium, magnesium, and potassium concentrations on ventricular repolarization in unselected individuals.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 957-972 (2019)
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
2019 Scientific Article in PLoS ONE PLoS ONE 14:e0216110 (2019)
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants.
2019 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 166, 11370-11379 (2019)
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk.
2019 Scientific Article in PLoS ONE PLoS ONE 14:e0216222 (2019)
Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.
2019 Scientific Article in European Respiratory Journal Eur. Respir. J. 54, 1-18:1900457 (2019)
Epigenome-wide association study of lung function level and its change.
2019Poster: RECOMB 2019, 4-8 May 2019, Washington D.C.. (2019)
Reconstructing regulatory networks from multi-omics data using prior information.
2019 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 188, 1033-1054 (2019)
Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions.
2019 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 28, 1381-1391 (2019)
Discovery of mitochondrial DNA variants associated with genome-wide blood cell gene expression: A population-based mtDNA sequencing study.
2019 Scientific Article in Aging Aging 11, 2045-2070 (2019)
Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis.
2019 Scientific Article in Metabolomics Metabolomics 15:60 (2019)
Exposure to disinfection byproducts and risk of type 2 diabetes: A nested case–control study in the HUNT and Lifelines cohorts.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 636-648 (2019)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
2019 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 73, 58-66 (2019)
Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 414-430 (2019)
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
2019 Scientific Article in Genetics Genetics 211, 1395–1407 (2019)
Modeling heterogeneity in the genetic architecture of ethnically diverse groups using random effect interaction models.
2019 Scientific Article in Neuropsychopharmacology Neuropsychopharmacology 44, 930-938 (2019)
Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression.
2019 Scientific Article in Nature Communications Nat. Commun. 10:376 (2019)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
2019 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 109, 276-287 (2019)
Disentangling the genetics of lean mass.
2019 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 27, 952-962 (2019)
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
2019 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol. 34, 409-422 (2019)
Protein markers and risk of type 2 diabetes and prediabetes: A targeted proteomics approach in the KORA F4/FF4 study.
2019 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 143, 2062-2074 (2019)
Epigenome-wide meta-analysis of DNA methylation and childhood asthma.
2018 Scientific Article in Neurology Genetics Neurol. Genet. 4:e293 (2018)
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes.
2018 Meeting abstract in European Heart Journal Eur. Heart J. 39, 998-998 (2018)
Using the plasma proteome to decipher metabolic syndrome pathophysiology and discover a diagnostic biomarker panel.
2018 Scientific Article in JAMA neurology JAMA Neurol. 75, 860-875 (2018)
Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum.
2018 Scientific Article in Clinical Epigenetics Clin. Epigenet. 10:161 (2018)
Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.
2018 Scientific Article in Nutrients Nutrients 10:1944 (2018)
Determinants of plasma docosahexaenoic acid levels and their relationship to neurological and cognitive functions in PKU patients: A double blind randomized supplementation study.
2018 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 108, 1135-1144 (2018)
The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants.
2018 Scientific Article in Nature Communications Nat. Commun. 9:4919 (2018)
Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests.
2018 Scientific Article in EBioMedicine EBioMedicine 38, 206-216 (2018)
Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1514-1523 (2018)
Genetics of blood lipids among similar to 300,000 multi-ethnic participants of the Million Veteran Program.
2018 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 103, 691-706 (2018)
Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:15249 (2018)
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
2018 Meeting abstract in Atherosclerosis Atherosclerosis 275, E104-E105 (2018)
Formyl peptide receptors 1-3 and annexin 1 in atherosclerotic plaques - tampere vascular study.
2018 Scientific Article in JAMA Psychiatry JAMA psychiatry 75, 949-959 (2018)
DNA methylation signatures of depressive symptoms in middle-aged and elderly persons meta-analysis of multiethnic epigenome-wide studies.
2018 Scientific Article in Nature Communications Nat. Commun. 9:3738 (2018)
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation.
2018 Scientific Article in Biomolecules Biomolecules 8:74 (2018)
Novel DNA methylation sites influence GPR15 expression in relation to smoking.
2018 Scientific Article in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 62:1800117 (2018)
Identification of comprehensive metabotypes associated with cardiometabolic diseases in the population-based KORA study.
2018 Scientific Article in Atherosclerosis Atherosclerosis 276, 140-147 (2018)
Ldlr-/- and ApoE-/- mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.
2018 Scientific Article in Nature Communications Nat. Commun. 9:3221 (2018)
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.
2018 Scientific Article in Metabolites Metabolites 8:45 (2018)
Night shift work affects urine metabolite profiles of nurses with early chronotype.
2018 Scientific Article in Nature Communications Nat. Commun. 9:2904 (2018)
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.
2018 Scientific Article in Genome Biology Genome Biol. 19:87 (2018)
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
2018 Scientific Article in Blood Blood 132, 1842-1850 (2018)
DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.
2018 Scientific Article in Atherosclerosis Atherosclerosis 276, 140-147 (2018)
Ldlr(-/-) and ApoE(-/-) mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.
2018 Scientific Article in International Archives of Occupational and Environmental Health Int. Arch. Occup. Environ. Health 91, 937-950 (2018)
Genetic modifiers of radon-induced lung cancer risk: A genome-wide interaction study in former uranium miners.
2018 Scientific Article in Scientific Reports Sci. Rep. 8, 10358:10358 (2018)
Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study.
2018 Scientific Article in PLoS ONE PLoS ONE 13:e0198166 (2018)
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
2018 Scientific Article in JAMA cardiology JAMA Cardiol. 3, 463-472 (2018)
Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor.
2018 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 11:e002037 (2018)
Common and rare coding genetic variation underlying the electrocardiographic PR interval.
2018 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 11:e001758 (2018)
ExomeChip-wide analysis of 95 626 individuals identifies 10 novel loci associated with QT and JT intervals.
2018 Review in Current Opinion in Lipidology Curr. Opin. Lipidol. 29, 116-124 (2018)
DNA methylation in human lipid metabolism and related diseases.
2018 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 102, 375-400 (2018)
A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure.
2018 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 27, 1106-1121 (2018)
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.
2018 Scientific Article in Environmental Health Perspectives Environ. Health Perspect. 126:027004 (2018)
Long-term air pollution exposure, genome-wide DNA methylation and lung function in the lifelines cohort study.
2018 Scientific Data Sci. Data 5:180002 (2018)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2018 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1708, 515-535 (2018)
Quantitative region-specific DNA methylation analysis by the EpiTYPER™ technology.
2018 Scientific Article in Journal of Autoimmunity J. Autoimmun. 89, 63-74 (2018)
Allele-specific methylation of type 1 diabetes susceptibility genes.
2018 Scientific Article in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1862, 637-648 (2018)
IgG glycosylation and DNA methylation are interconnected with smoking.
2018 Scientific Article in Carcinogenesis Carcinogenesis 39, 336-346 (2018)
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.
2018 Scientific Article in Pediatric Allergy and Immunology Pediatr. Allergy Immunol. 29, 34-41 (2018)
IRF-1 SNPs influence the risk for childhood allergic asthma: A critical role for pro-inflammatory immune regulation.
2018 Scientific Article in Journal of Proteome Research J. Proteome Res. 17, 203-211 (2018)
Long-Term Stability of Human Plasma Metabolites during Storage at-80 degrees C.
2018 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 47, 22-23u (2018)
Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium.
2018 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 57, 2583-2594 (2018)
Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study.
2018 Scientific Article in Neuropsychopharmacology Neuropsychopharmacology 43, 342-353 (2018)
Anxiety associated increased CpG methylation in the promoter of Asb1: A translational approach evidenced by epidemiological and clinical studies and a murine model.
2018 Scientific Article in Molecular Psychiatry Mol. Psychiatry 23, 422-433 (2018)
A DNA methylation biomarker of alcohol consumption.
2017 Scientific Article in Biostatistics Biostatistics 18, 477-494 (2017)
A powerful and efficient two-stage method for detecting gene-to-gene interactions in GWAS.
2017 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 25, 137-146 (2017)
Across-cohort QC analyses of GWAS summary statistics from complex traits.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1722–1730 (2017)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
2017 Scientific Article in Scientific Data Sci. Data 4:170179 (2017)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2017 Scientific Article in Brain: A Journal of Neurology Brain 140, 3191-3203 (2017)
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1758-1766 (2017)
Exome-wide association study of plasma lipids in >300,000 individuals.
2017 Scientific Article in OncoTarget Oncotarget 8, 98623-98634 (2017)
Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.
2017 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank. 15, 512-518 (2017)
Influence of storage and inter- and Intra-assay variability on the measurement of inflammatory biomarkers in population-based biobanking.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 22, 1680-1690 (2017)
An epigenome-wide association study meta-analysis of educational attainment.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:14349 (2017)
DNA-methylation and body composition in preschool children: Epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-Study.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:14111 (2017)
Evidence for stress-like alterations in the HPA-Axis in women taking oral contraceptives.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0182472 (2017)
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.
2017 Scientific Article in Neurology Neurology 89, 1829-1839 (2017)
COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
2017 Scientific Article in BMC Genomics BMC Genomics 18:805 (2017)
The dynamics of smoking-related disturbed methylation: A two time-point study of methylation change in smokers, non-smokers and former smokers.
2017 Scientific Article in Genetics Genetics 207, 1275-1283 (2017)
RL-SKAT: An exact and efficient score Test for heritability and set tests.
2017 Scientific Article in BMC Bioinformatics BMC Bioinformatics 18:429 (2017)
pulver: An R package for parallel ultra-rapid p-value computation for linear regression interaction terms.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:12127 (2017)
Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm - The Tampere Vascular Study.
2017 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 10:e001667 (2017)
Fifteen genetic loci associated with the electrocardiographic P wave.
2017 Scientific Article in Diabetologia Diabetologia 61, 117-129 (2017)
Metabolite ratios as potential biomarkers for type 2 diabetes: A DIRECT study.
2017 Meeting abstract in Allergy Allergy 72, 53-53 (2017)
Association of atopic dermatitis with cardiovascular risk factors and diseases.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:11303 (2017)
Genetic interactions with age, sex, body mass index, and hypertension in relation to atrial fibrillation: The AFGen Consortium.
2017 Scientific Article in JAMA neurology JAMA Neurol. 74, 780-792 (2017)
Genome-wide pleiotropy between Parkinson disease and autoimmune diseases.
2017 Scientific Article in Diabetes/Metabolism Research and Reviews Diabetes Metab. Res. Rev. 33:e2914 (2017)
Blood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia. The Cardiovascular Risk in Young Finns Study.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:6037 (2017)
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1126-1132 (2017)
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
2017 Scientific Article in Circulation Circulation 135, 2336-2353 (2017)
Loss of cardioprotective effects at the ADAMTS7 locus as a result of gene-smoking interactions.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15805 (2017)
Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
2017 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 26, 2346-2363 (2017)
Discovery of novel heart rate-associated loci using the Exome Chip.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 946-952 (2017)
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
2017 Scientific Article in Biological Psychiatry Biol. Psychiatry 81, 325-335 (2017)
Genome-wide association for major depression through age at onset stratification: Major depressive disorder working group of the Psychiatric Genomics Consortium.
2017 Scientific Article in European Journal of Vascular and Endovascular Surgery Eur. J. Vasc. Endovasc. Surg. 53, 632-640 (2017)
Synergistic expression of histone deacetylase 9 and matrix metalloproteinase 12 in M4 macrophages in advanced carotid plaques.
2017 Scientific Article in Diabetes Diabetes 66, 2019-2032 (2017)
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:45040 (2017)
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
2017 Scientific Article in Nature Communications Nat. Commun. 8:14977 (2017)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
2017 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, 3613-3618 (2017)
Common coding variant in SERPINA1 increases the risk for large artery stroke.
2017 Scientific Article in Nature Communications Nat. Commun. 8:14617 (2017)
DNA methylation signatures in peripheral blood strongly predict all-cause mortality.
2017 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 981-994 (2017)
SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function.
2017 Scientific Article in BMJ Open BMJ Open 7:e012475 (2017)
Study protocol to investigate the environmental and genetic aetiology of atopic dermatitis: The Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI).
2017 Scientific Article in Heart Heart 103, 1278-1285 (2017)
Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 403-415 (2017)
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
2017 Scientific Article in Genome Biology Genome Biol. 18:22 (2017)
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
2017 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 69, 823-836 (2017)
Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:41483 (2017)
Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques-Tampere Vascular Study.
2017 Scientific Article in Nature Nature 542, 186-190 (2017)
Rare and low-frequency coding variants alter human adult height.
2017 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 10:1 (2017)
Genome-wide methylation data mirror ancestry information.
2017 Scientific Article in Nature Nature 541, 81-86 (2017)
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
2017 Scientific Article in Cancer Epidemiology, Biomarkers & Prevention Cancer Epidemiol. Biomarkers Prev. 26, 126-135 (2017)
The OncoArray Consortium: A network for understanding the genetic architecture of common cancers.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 22, 192-201 (2017)
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 5483-5489 (2016)
Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: Evidence for oligogenic inheritance.
2016 Meeting abstract in Diabetologia Diabetologia 59, S527-S527 (2016)
Increased serum levels of interleukin-1 receptor antagonist (IL-1ra) precede coronary heart disease: Meta-analysis of 4 prospective cohort studies.
2016 Meeting abstract in Diabetologia Diabetologia 59, S142-S143 (2016)
A metabolite ratio associates with measures of insulin secretion and altered risk of type 2 diabetes; a DIRECT study.
2016 Scientific Article in BMC Bioinformatics BMC Bioinformatics 17:480 (2016)
A statistical model for the analysis of beta values in DNA methylation studies.
2016 Meeting abstract in Annals of Nutrition and Metabolism Ann. Nutr. Metab. 69, 113-113 (2016)
Epigenome-wide DNA-methylation and body composition at age 5.5 years in the European childhood obesity project (CHOP)-study.
2016 Meeting abstract in Atherosclerosis Atherosclerosis 252, E263-E263 (2016)
Associations between lipoprotein subfractions and genome-wide DNA methylation in KORA F4.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:38262 (2016)
Blood hsa-MIR-122-5p and hsa-MIR-885-5p levels associate with fatty liver and related lipoprotein metabolism - The Young Finns Study.
2016 Scientific Article in Genome Biology Genome Biol. 17:255 (2016)
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.
2016 Scientific Article in Brain: A Journal of Neurology Brain 139, 3163-3169 (2016)
Genome-wide association study in essential tremor identifies three new loci.
2016 Scientific Article in Clinical Epigenetics Clin. Epigenet. 8:124 (2016)
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0165548 (2016)
Are epigenetic factors implicated in chronic widespread pain?
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0166015 (2016)
Epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:35371 (2016)
Gene-gene interaction analyses for atrial fibrillation.
2016 Scientific Article in Atherosclerosis Atherosclerosis 255, 43-53 (2016)
Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.
2016 Scientific Article in BMJ Open BMJ Open 6:e012070 (2016)
'Omics' biomarkers associated with chronic low back pain: Protocol of a retrospective longitudinal study.
2016 Scientific Article in Sleep Sleep 39, 1859-1869 (2016)
Heritability and genome-wide association analyses of sleep duration in children: The EAGLE Consortium.
2016 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 9, 436-447 (2016)
Epigenetic signatures of cigarette smoking.
2016 Scientific Article in Aging Aging 8, 1844-1865 (2016)
DNA methylation-based measures of biological age: Meta-analysis predicting time to death.
2016 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 68, 1435-1448 (2016)
52 Genetic loci influencing myocardial mass.
2016 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 45, 1469-1481 (2016)
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: A cross-sectional analysis in population-based data.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 4611-4623 (2016)
A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking.
2016 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 68, 934-945 (2016)
Cystatin C and cardiovascular disease: A mendelian randomization study.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 4094-4106 (2016)
Analysis with the exome array identifies multiple new independent variants in lipid loci.
2016 Scientific Article in Appetite Appetite 107, 126-134 (2016)
Association of TAS2R38 variants with sweet food intake in children aged 1-6 years.
2016 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 136, 2380-2386 (2016)
Targeted resequencing and functional testing identifies low-frequency missense variants in the gene encoding GARP as significant contributors to atopic dermatitis risk.
2016 Scientific Article in Science Advances Sci. Adv. 2:e1501678 (2016)
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
2016 Scientific Article in Diabetologia Diabetologia 59, 1882-1892 (2016)
MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: The KORA F4 study.
2016 Scientific Article in Circulation Research Circ. Res. 118, 83-94 (2016)
Identifying novel gene variants in coronary artery disease and shared genes with several cardiovascular risk factors.
2016 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 36, 928-941 (2016)
Network-based identification and prioritization of key regulators of coronary artery disease loci.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1006034 (2016)
Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure.
2016 Scientific Article in Carcinogenesis Carcinogenesis 37, 677-684 (2016)
Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: Replication study in a German population.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0155554 (2016)
Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: Epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-study.
2016 Scientific Article in Lancet Neurology, The Lancet Neurol. 15, 585-596 (2016)
Deletions at 22q11.2 in idiopathic Parkinson's disease: A combined analysis of genome-wide association data.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0153163 (2016)
The pharmacogenetic footprint of ACE inhibition: A population-based metabolomics study.
2016 Scientific Article in New England Journal of Medicine, The / NEJM N. Engl. J. Med. 374, 1134-1144 (2016)
Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11122 (2016)
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
2016 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 98, 500-513 (2016)
Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 138, 421-431 (2016)
Doublesex and Mab-3 Related Transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.
2016 Scientific Article in Lancet Neurology, The Lancet Neurol. 15, 174-184 (2016)
Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study.
2016 Scientific Article in Neurobiology of Aging Neurobiol. Aging 38, 214.e7-214.e10 (2016)
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.
2016 Scientific Article in Stroke Stroke 47, 307-316 (2016)
Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near HABP2.
2016 Scientific Article in Environmental Health Perspectives Environ. Health Perspect. 124, 983-990 (2016)
A genome-wide analysis of DNA methylation and fine particulate matter air pollution in three study populations: KORA F3, KORA F4, and the Normative Aging Study.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 358-370 (2016)
A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration.
2016 Scientific Article in Diabetes Diabetes 65, 574-584 (2016)
A high fat diet during mouse pregnancy and lactation targets GIP-regulated metabolic pathways in adult male offspring.
2016 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 55, 1633-1644 (2016)
Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: Results of a randomised controlled trial.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 191-201 (2016)
Prenatal and early life influences on epigenetic age in children: A study of mother-offspring pairs from two cohort studies.
2016 Scientific Article in Molecular Psychiatry Mol. Psychiatry 21, 108–117 (2016)
A novel Alzheimer disease locus located near the gene encoding tau protein.
2015 Scientific Article in OncoTarget Oncotarget 6, 42468-42477 (2015)
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
2015 Meeting abstract in Arthritis & Rheumatology Arthritis Rheum. 67:1623 (2015)
Genome-wide association study of DNA methylation in Th1 and Th17 cells in rheumatoid arthritis.
2015 Other: Opinion in Obstetrics & Gynecology Obstet. Gynecol. 70, 758-762 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1415-1425 (2015)
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 601-608 (2015)
Successful replication of GWAS hits for multiple sclerosis in 10,000 Germans using the exome array.
2015 Meeting abstract in Genetic Epidemiology Genet. Epidemiol. 39, 571 (2015)
Genome-wide association analysis with multivariate ECG traits.
2015 Scientific Article in Journal of Psychiatric Research J. Psychiatr. Res. 71, 120-125 (2015)
Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1294-1303 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8570 (2015)
The transcriptional landscape of age in human peripheral blood.
2015 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 8:43 (2015)
Characterization of whole-genome autosomal differences of DNA methylation between men and women.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 6711-6720 (2015)
A systematic screening to identify de novo mutations causing sporadic early-onset Parkinson's disease.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1282-1293 (2015)
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 717-726 (2015)
Molecular characterization of the NLRC4 expression in relation to interleukin-18 levels.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005487 (2015)
Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality.
2015 Scientific Article in Neurobiology of Aging Neurobiol. Aging 36, 2907.e13-2907.e17 (2015)
Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S58 (2015)
Targeted resequencing and finemapping identifies functional low-frequency missense variants in LRRC32 as risk factors for atopic dermatitis.
2015 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 24, 521-528 (2015)
Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
2015 Scientific Article in Diabetes Care Diabetes Care 38, 1858-1867 (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
2015 Meeting abstract in Movement Disorders Mov. Disord. 30, S412 (2015)
Genome wide pleiotropic study in 144,701 subjects reveals shared genetic variants between Parkinson's disease and immune-mediated diseases.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 5733-5745 (2015)
Layered genetic control of DNA methylation and gene expression: A locus of multiple sclerosis in healthy individuals.
2015 Scientific Article in Atherosclerosis Atherosclerosis 242, 145-154 (2015)
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0121495 (2015)
Pre-analytical sample quality: Metabolite ratios as an intrinsic marker for prolonged room temperature exposure of serum samples.
2015 Scientific Article in Lancet Neurology, The Lancet Neurol. 14, 678-679 (2015)
CHCHD2 and Parkinson's disease.
2015 Scientific Article in Nature Nature 523, 459-462 (2015)
Directional dominance on stature and cognition in diverse human populations.
2015 Scientific Article in Blood Blood 126, e19-e29 (2015)
Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.
2015 Scientific Article in Movement Disorders Mov. Disord. 30, 850-854 (2015)
Genetic risk and age in Parkinson's disease: Continuum not stratum.
2015 Scientific Article in Allergy Allergy 70, 1288-1299 (2015)
Childhood asthma is associated with mutations and gene expression differences of ORMDL genes which can interact.
2015 Scientific Article in SpringerPlus SpringerPlus 4:206 (2015)
Interleukin-6 and microRNA profiles induced by oral bacteria in human atheroma derived and healthy smooth muscle cells.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 334-342 (2015)
DNA methylation of lipid-related genes affects blood lipid levels.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0126294 (2015)
Mitochondrial GWA analysis of lipid profile identifies genetic variants to be associated with HDL cholesterol and triglyceride levels.
2015 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 136, 893-903 (2015)
Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
2015 Meeting abstract in Experimental Dermatology Exp. Dermatol. 24, E17-E18 (2015)
Targeted resequencing and finemapping identifies low-frequency missense variants in LRRC32 as risk factors for atopic dermatitis.
2015 Scientific Article in European Heart Journal Eur. Heart J. 36, 1669-1675 (2015)
Predicting sudden cardiac death using common genetic risk variants for coronary artery disease.
2015 Meeting abstract in Human Heredity Hum. Hered. 79, 32-33 (2015)
Exome array GWAS in 10,000 Germans identifies association between MUC22 and multiple sclerosis.
2015 Scientific Article in British Journal of Nutrition Br. J. Nutr. 113, 1782-1791 (2015)
Vitamin E supplementation is associated with lower levels of C-reactive protein only in higher dosages and combined with other antioxidants: The Cooperative Health Research in the Region of Augsburg (KORA) F4 study.
2015 Scientific Article in Journal of the American Heart Association J. Am. Heart Assoc. 4:e001544 (2015)
Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.
2015 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 136, 802-806 (2015)
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.ϖ
2015 Nature Communications Nat. Commun. 6:6542 (2015)
Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0119752 (2015)
Modulation of genetic associations with serum urate levels by body-mass-index in humans.
2015 Scientific Article in Human Genetics Hum. Genet. 134, 627-636 (2015)
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005035 (2015)
A meta-analysis of gene expression signatures of blood pressure and hypertension.
2015 Scientific Article in BMC Medicine BMC Med. 13:48 (2015)
Multi-omic signature of body weight change: Results from a population-based cohort study.
2015 Scientific Article in Translational Psychiatry Transl. Psychiatry 5:e524 (2015)
Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder.
2015 Scientific Article in Circulation Circulation 131, 774-785 (2015)
Metabolite profiling and cardiovascular event risk: A prospective study of three population-based cohorts.
2015 Scientific Article in Journal of Neurology, Neurosurgery, and Psychiatry J. Neurol. Neurosurg. Psychiatr. 86, 986-995 (2015)
Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 159-167 (2015)
Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.
2015 Scientific Article in Environmental Health Perspectives Environ. Health Perspect. 123, 193-199 (2015)
Prenatal exposure to maternal cigarette smoking and DNA methylation: Epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age.
2015 Scientific Article in Molecular Psychiatry Mol. Psychiatry 20, 647-656 (2015)
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
2015 Scientific Article in Journal of Psychiatry & Neuroscience : An International Journal J. Psychiatry Neurosci. 39, 38-45:130263 (2015)
Prenatal exposure to cigarette smoke interacts with OPRM1 to modulate dietary preference for fat.
2015 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 135, 573-576 (2015)
Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts.
2015 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 135, 81-91 (2015)
Identification of novel immune phenotypes for allergic and nonallergic childhood asthma.
2015 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 54, 173-181 (2015)