Lehmann Lab

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Lung Inflammaging

The Lehmann Lab aims to understand how aging predisposes the lung to the development of chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

The Lehmann Lab aims to understand how aging predisposes the lung to the development of chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

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We aim to understand how cellular aging affects stem cell capacities and cell-cell crosstalk, especially between immune cells and stem cells. In order to allow the aging lung to efficiently repair, we aim to develop biomarkers as well as therapeutic strategies targeting cellular aging phenotypes, thereby opening novel avenues for the diagnosis and treatment of chronic lung diseases.

To be able to test potential anti-senescent therapies in the human system, we are developing a human aging model based on human precision cut lung slices (PCLS) that displays relevant hallmarks of aging such as cellular senescence. This model will be used to verify target engagement of anti-senescent therapies in the human system and will help to screen for relevant biomarkers for companion diagnostics development.

Lung Organoids under the microscope

Camila Melo Narvaez

Camila Melo Narvaez

Postdoc

Fenja See

Fenja See

Doctoral Student (MD)

Portrait Carina Steinchen LHI

Carina Steinchen

MD student

Anisha Mayuresh Thite

Anisha Mayuresh Thite

MD Student

2024 Cells

Maria Camila Melo-Narváez et al.

Stimuli-Specific Senescence of Primary Human Lung Fibroblasts Modulates Alveolar Stem Cell Function

2022 European Respiratory Journal

Heinzelmann, K. et al.

Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis

2020 Nature

Thomas M. Conlon et al.

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

2020 Cellular Signalling

Mareike Lehmann et al.

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells

2017 American Journal of Physiology

Hani N. Alsafadi et al.

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices

2017 European Respiratory Journal

Lehmann, M. et al

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo