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Airway Immunology

Lab Jakwerth

The Airway Immunology Group aims to understand how environmental triggers can cause diseases like allergic rhinitis, asthma, or infections like COVID-19. 

The Airway Immunology Group aims to understand how environmental triggers can cause diseases like allergic rhinitis, asthma, or infections like COVID-19.

About our Research

The airway epithelial cells constitute the barrier to our environment and, together with immune cells scattered in this layer, are the first cells to be exposed to environmental components such as allergens, viruses, or pollutant particles.

The focus of the Airway Immunology Group is on epithelial cell biology and its cross-talk with the immune system (T cells, innate lymphocytes, and macrophages). There are critical changes in the airway epithelium that can prime both epithelial differentiation and the immune system, ultimately leading to the pathogenesis of allergic asthma. We investigate the role of the airway epithelium in allergic inflammation under the influence of Th1/Th2 mediators. It is important to understand the interaction between epithelial cells and immune cells to identify specific biomarkers for allergic inflammation. Allergen-specific immunotherapy is another focus under investigation, and therapeutic efficacy is also being investigated at the epithelial barrier. The group is also interested in food allergies and the gut barrier. Airway projects are funded by the DZL (German Lung Research Center), biomarker studies are supported by the ZAUM-led EIT Health EU consortium "ADAPT". Food allergies are investigated in the BMBF consortium "ABROGATE" led by ZAUM.

Scientists at Airway Immunology

Dr. Constanze Jakwerth

Priv.-Doz. Dr. rer. nat. Constanze Jakwerth

Group Leader Airway Immunology Profil anzeigen

Stefanie Glocker

Technician

Helen Charles

PhD Student

Maryéva Bessemoulin

PhD Student

Publications

Weiterlesen

2024 Wissenschaftlicher Artikel in Nature Communications

Geiselhöringer, A.-L. ; Kolland, D. ; Patt, A.J. ; Hammann, L. ; Köhler, A. ; Kreft, L. ; Wichmann, N. ; Hils, M. ; Ruedl, C. ; Riemann, M. ; Biedermann, T. ; Anz, D. ; Diefenbach, A. ; Voehringer, D. ; Schmidt-Weber, C.B. ; Straub, T. ; Szente-Pasztoi, M. ; Ohnmacht, C.

Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity.

2024 Wissenschaftlicher Artikel in Environment International

Schneider, E. ; Amar, Y. ; Butter, K. ; Steiger, K. ; Musiol, S. ; Garcia-Käufer, M. ; Hölge, I.M. ; Schnautz, B. ; Gschwendtner, S. ; Ghirardo, A. ; Gminski, R. ; Eberlein, B. ; Esser-von Bieren, J. ; Biedermann, T. ; Haak, S. ; Ohlmeyer, M. ; Schmidt-Weber, C.B. ; Eyerich, S. ; Alessandrini, F.

Pinewood VOC emissions protect from oxazolone-induced inflammation and dysbiosis in a mouse model of atopic dermatitis.

Contact

Dr. Constanze Jakwerth

Priv.-Doz. Dr. rer. nat. Constanze Jakwerth

Group Leader Airway Immunology