Lab Jakwerth
Airway Immunology
The Airway Immunology Group aims to understand how environmental triggers can cause diseases like allergic rhinitis, asthma, or infections like COVID-19.
About our Research
The airway epithelial cells constitute the barrier to our environment and, together with immune cells scattered in this layer, are the first cells to be exposed to environmental components such as allergens, viruses, or pollutant particles.
The focus of the Airway Immunology Group is on epithelial cell biology and its cross-talk with the immune system (T cells, innate lymphocytes, and macrophages). There are critical changes in the airway epithelium that can prime both epithelial differentiation and the immune system, ultimately leading to the pathogenesis of allergic asthma. We investigate the role of the airway epithelium in allergic inflammation under the influence of Th1/Th2 mediators. It is important to understand the interaction between epithelial cells and immune cells to identify specific biomarkers for allergic inflammation. Allergen-specific immunotherapy is another focus under investigation, and therapeutic efficacy is also being investigated at the epithelial barrier. The group is also interested in food allergies and the gut barrier. Airway projects are funded by the DZL (German Lung Research Center), biomarker studies are supported by the ZAUM-led EIT Health EU consortium "ADAPT". Food allergies are investigated in the BMBF consortium "ABROGATE" led by ZAUM.
Postdoc
Technician
PhD Student
PhD Student
MD student
MD student
MD student
MD student
Publications
Žilka, M. ; Alashhab, S. ; Ščevková, J. ; Schmidt-Weber, C.B. ; Wessels, I. ; Buters, J.T.M. ; Gonzalez-Alonso, M.
Advances in automatic airborne fungal spore monitoring: Detection-efficiency test of the BAA500.Charles, H. ; Gabr, A.A. ; Wang, S.-H. ; Zissler, U.M. ; Heine, S. ; Heldner, A. ; Kotz, S. ; Pechtold, L. ; Bonsen, L.S.Z. ; Pogorelov, D. ; Kau, J. ; Plaschke, M. ; Hills, M. ; Guerth, F. ; Oelsner, M. ; Ohnmacht, C. ; Alessandrini, F. ; Blank, S. ; Chaker, A. ; Schmidt-Weber, C.B. ; Jakwerth, C.A.
TNF pathway-mediated tolerogenic T-cell trajectory driven by allergen immunotherapy.Pelamatti, E. ; Urban, S. ; Rauer, D. ; Schnautz, B. ; Eggestein, A. ; Kolek, F. ; Grosch, J. ; Stapelfeldt, A. ; Damialis, A. ; Sener, A. ; Schmidt-Weber, C.B. ; Traidl-Hoffmann, C. ; Alessandrini, F. ; Aglas, L. ; Gilles, S.
Defining in vivo and in vitro models for evaluating the sensitising potential of birch pollen extracts.Contact