Portrait of Holger Prokisch, Group Leader of Multiomics for Disease Diagnostics, Institut of Neurogenomics

Group Leader, Institut of Neurogenomics

Holger Prokisch

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Research Focus

We are an interdisciplinary group of researchers exploring various multiomic approaches to investigate how the genome contributes to diseases. We develop new computational methods for patient diagnosis, treatment and data management. Our group’s core competencies include medicine, molecular biology and data science. We study both rare and complex diseases on a molecular/genetic level. In doing so, we aim to either provide a genetic diagnosis or gain more knowledge about the pathomechanism of the disease. We collaborate with researchers around the globe in hopes of fostering international exchange and bringing new advancements in science to the healthcare sector. 

Fields of Work and Expertise

Medical Genomics

Mitochondrial Disorders

Rare Disorder Registry

Familiar Hypercholesterinemia 

Professional Background

Since 2025

Group leader Multiomics for Disease Diagnostics, Institut of Neurogenomics

Since 2025

Group leader "Multiomics for Disease Diagnostics in Metabolic Disorders“ Institut für Humangenetik, TUM Klinikum

2004

Group leader „Genomics of Mitochondrial Disorders“, Institut für Humangenetik, TUM Klinikum & Helmholtz München

1999

Group leader “Biogenesis of Mitochondria”, Institute of Physiological Chemistry, University of Munich

1998

Post-doc at the Institute of Physiological Chemistry, University of Munich

1997

PhD in Biology, Institute of Applied Genetics, University of Hannover

1994

Dipl. Biol. Institute of Applied Genetics, University of Hannover

Honors and Awards

  • 2024 - The German Society of Human Genetics (GfH)

Recent Publications

2021 J Clin Invest

Stenton SL, Sheremet NL, Catarino CB, Andreeva NA, Assouline Z, Barboni P, Barel O, Berutti R, Bychkov I, Caporali L, Capristo M, Carbonelli M, Cascavilla ML, Charbel Issa P, Freisinger P, Gerber S, Ghezzi D, Graf E, Heidler J, ......, Prokisch H

Impaired complex I repair causes recessive Leber's hereditary optic neuropathy
2021 Deutsches Ärzteblatt International

Klopstock T, Priglinger C, Yilmaz A, Kornblum C, Distelmaier F, Prokisch H.

Mitochondrial Disorders
2022 Genome Medicine

Yépez VA, Gusic M, Kopajtich R, Mertes C, Smith NH, Alston CL, Ban R, Beblo S, Berutti R, Blessing H, Ciara E, Distelmaier F, Freisinger P, Häberle J, Hayflick SJ, Hempel M, Itkis YS, Kishita Y, Klopstock T, Krylova TD, Lamperti C,
.........., J, Prokisch H.

Clinical implementation of RNA sequencing for Mendelian disease diagnostics
2024 Hepatology

Lenz D, Schlieben LD, Shimura M, Bianzano A, Smirnov D, Kopajtich R, Berutti R, Adam R, Aldrian D, Baric I, Baumann U, Bozbulut NE, Brugger M, Brunet T, Bufler P, Burnytė B, Calvo PL, Crushell E, Dalgiç B, Das AM, Dezsőfi A, Distelmaier F, Fichtner A, Freisinger P, Garbade SF, ..............,Prokisch H.

Genetic landscape of pediatric acute liver failure of indeterminate origin
2026 Brain

Peymani F, Ebihara T, Smirnov D, Kopajtich R, Ando M, Bertini E, Carrozzo R, Diodato D, Distelmaier F, Fang F, Ghezzi D, Hempel M, Iwanicka-Pronicka K, Klopstock T,........, Prokisch H.

Pleiotropic effects of MORC2 derive from its epigenetic signature

Networks and Affiliations

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mitoNET

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Logo Digimed Bayern

DigiMed

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GENOMIT

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Recon4IMD

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PerMiM

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SEI-MITO

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