Dr. Florian Giesert

Florian Giesert’s research lies at the interface of gene editing, RNA biology, and translational medicine, with a focus on enabling next-generation nucleic acid therapeutics. By combining advanced CRISPR technologies with innovative delivery strategies, his work aims to overcome key barriers in the safe and targeted application of gene and RNA-based therapies in vivo.

From genetic tools to therapeutic platforms

Florian studied biology with a focus on genetics at the Technical University of Munich, where he obtained his doctoral degree. His early research focused on functional genetics and disease modeling, particularly in neurodegenerative disorders. During his postdoctoral work at Helmholtz Munich and the Technical University of Munich, he expanded his expertise in genetic engineering and contributed to the development of advanced tools for genome manipulation. As team leader for Genetic Tools Development and head of the transgenic unit, he established key platforms for genome engineering and disease modeling.

Engineering RNA delivery systems for translational medicine

As head of the Gene Editing Group at the Institute of Stem Cell Research, his research focuses on the development of innovative gene editing and RNA delivery systems, including synthetic transport vehicles (STVs) for precise in vivo delivery. By combining molecular engineering with preclinical validation, his group drives the translation of gene editing technologies toward clinical application, supported by programs such as the m4 Award and GoBio Next.