Portrait Franz Hagn

Research Group Leader

Prof. Dr. Franz Hagn

Our labs and offices are located in the new BNMRZ building on the research campus in Garching. 

Contact Prof. Franz Hagn franz.hagnspam prevention@tum.de or  office.membranespam prevention@ch.tum.de for general inquiries.

Anschrift: 

Structural Membrane Biochemistry (Prof. Hagn)
TUM School of Natural Sciences, Dept. Bioscience
Technical University of Munich
Lichtenbergstrasse 4
85748 Garching

Visit the research website

Academic Career and Research Areas

Franz Hagn’s research explores how membrane proteins control the transport of metabolites and signals across biological membranes, a process fundamental to cell function and health. His lab investigates a range of disease-linked membrane proteins, including mitochondrial proteins, chloroplast transporters, and G-protein coupled receptors (GPCRs), as well as their interactions with partner proteins. These proteins are central to metabolism, signaling, and energy production, and their dysfunction is linked to diseases such as neurodegeneration, metabolic disorders, and cancer. Dr. Hagn combines structural biology, biophysical, and biochemical approaches to study protein structure, dynamics, and interactions. 

Franz Hagn earned his Dr. rer. nat. at Technische Universität München, completed postdoctoral research at Harvard Medical School. He joined Helmholtz Munich in 2015 as both, an Helmholtz Young Investigator group leader and Rudolf-Mössbauer Assistant Professor at TUM. Currently he is a groupl eader in membrane protein NMR at the Institute for Structural Biology and Associate Professor at the TUM School of Natural Sciences.

Fields of Work and Expertise

Apoptosis Membrane Proteins Mitochondrial Diseases Structural Biology

Professional Background

since 10/2020

Associate Professor, Department of Bioscience, TUM School of Natural Sciences

since 10/2020

Group leader "Membrane Protein NMR", Institute of Structural Biology, Helmholtz Munich

10/2015-09/2020

Helmholtz Young Investigator's group leader, Institute of Structural Biology, Helmholtz Munich

10/2014-09/2020

Rudolf-Mössbauer Assistant Professor at TUM-IAS and the Department of Chemistry at TUM

Honors and Awards

  • 2019 - Felix-Bloch-Lecture of the Magnetic Resonance Division of the GdCh
  • 2013 - Hans-Fischer Junior Fellowship, Institute for Advanced Study, TU München
  • 2012 - Arnold-Sommerfeld Award of the Bavarian Academy of Sciences
  • 2011 - Hans-Fischer Award 2011, Department Chemie, TU München
  • 2011 - Friedrich-Weygand Award 2011 of the Max-Bergmann Kreis for peptide chemistry

Recent Publications

2025

Daniilidis M, Günsel U, Broutzakis G, Leitl KD, Janowski R, Fredriksson K, Niessing D, Gatsogiannis C, Hagn F

Structural basis of apoptosis induction by the mitochondrial voltage-dependent anion channel
2023

Günsel U*, Klöpfer K*, Häusler E*, Hitzenberger M, Bölter B, Sperl LE, Zacharias M, Soll J, and Hagn F

Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21
2021

Sperl LE, Rührnößl F, Schiller A, Haslbeck M and Hagn F

High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane

Media Coverage

Press releases by TUM and Helmholtz Munich

New switch for programmed cell death identified

Helmholtz Munich

Networks and Affiliations

Technical University of Munich

Technical University of Munich

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Helmholtz Munich

Helmholtz Munich

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