Principal Investigator Environmental Epigenetics Group / Institute of Experimental Genetics
Dr. Raffaele Teperino
"It is my vision to understand how and how much we - as parents - contribute to the health of our offspring to manage individual disease susceptibility and prevent complex diseases, such as diabetes and obesity."
Research Areas
Raffaele Teperino is an enthusiastic Italian scientist, who likes to explore the ontogeny of individual phenotypes and disease susceptibilities. Especially interested in complex phenotypes and metabolic diseases, Raffaele is fascinated by epigenetic phenomena in particular those underlying parental control of offspring health. Working with a team of motivated young scientists makes Raffaele feel happy and lucky. His mottos are: “together we win” and “let the data speak”.
The overarching goal of the Environmental Epigenetics group is to study the interface between genetics, lifestyle, epigenetics and systems physiology with a special focus on parental effects, epigenetic inheritance and early programming of phenotypic plasticity and late onset diseases, such diabetes, obesity and neurodegeneration.
Fields of Work and Expertise
Energy homeostasis Diabetes Obesity Circadian rhythmEpigenetics Inheritance Spermatogenesis Early development Parental effects Developmental programming
Raffaele Teperino is a physiologist and pharmacologist by training and obtained a PhD in Molecular Pathology at the University of Naples with a thesis on genetic and epigenetic alterations in type 2 diabetes. After completing his PhD, Raffaele joined the group of Prof. J. Auwerx at the École Polytechnique Fédérale de Lausanne (EPFL) for a first postdoc. There he worked on the cross-talk between cellular metabolism and epigenetics. Afterwards, he took a second postdoc in Freiburg (DE) at the Max Planck Institute for Immunobiology and Epigenetics in the group of Dr. A. Pospisilik to shed light on the role of developmental regulators (including epigenetic modifiers) in adult metabolic physiology.
Since 2015 Raffaele Teperino has joined the Institute of Experimental Genetics at the Helmholtz Munich, where he is heading the Environmental Epigenetics research group.
Academic Career
Principal Investigator at Helmholtz Munich
Postdoctoral fellow at the MPI in Freiburg
Postdoctoral fellow at the EPFL in Lausanne
Honors and Awards
- Fritz-Thyssen Stiftung Research Grant 2019
- Helmholtz ERC Recognition Award 2017
- ARCHES Award from the Minerva Association 2016
- EUGENE2 Young Investigator Award 2006
Selected Publications
Teperino, R.
Paternal health before conception - a neglected dimension of disease prevention Young Investigator Award 2025-Brief Overview of Award Winner Raffaele Teperino.Harten, A. ; Schmidtke, M. ; Giesert, F. ; Skerrett-Byrne, D.A. ; Teperino, R. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.
MODY PDX1P33T: A mouse model reveals phenotypic divergence from human disease.Winkler, R. ; Comas-Armangue, G. ; Corujo, D. ; Sanz-Moreno, A. ; Calzada-Wack, J. ; Bhattacharya, S.A. ; Rathkolb, B. ; Dragano, N.R.V. ; Qiao, C.X. ; Chiodi, V. ; Filipescu, D. ; Park, D.H. ; Domenici, M.R. ; Kirigin Callaú, V. ; Gerlini, R. ; Rozman, J. ; Klein-Rodewald, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Seisenberger, C. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bernstein, E. ; Vinciguerra, M. ; Oberdoerffer, P. ; Hrabě de Angelis, M. ; Teperino, R. ; Buschbeck, M.
Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.Skerrett-Byrne, D.A. ; Pepin, A.-S. ; Laurent, K. ; Beckers, J. ; Schneider, R. ; Hrabě de Angelis, M. ; Teperino, R.
Dad's diet shapes the future: How paternal nutrition impacts placental development and childhood metabolic health.Pini, T. ; Nixon, B. ; Timothy L, K. ; Teperino, R. ; Sanz-Moreno, A. ; da Silva Buttkus, P. ; Tüttelmann, F. ; Kliesch, S. ; Gailus-Durner, V. ; Fuchs, H. ; Marschall, S. ; Hrabě de Angelis, M. ; Skerrett-Byrne, D.A.
Towards a kingdom of reproductive life - the core sperm proteome.Teperino, R.
Intergenerational metabolic effects of cold exposure.Aljabali, S. M. ; Pai, S. ; Teperino, R.
Paternal impact on the developmental programming of sexual dimorphism.Trigg, N. ; Schjenken, J.E. ; Martin, J.H. ; Skerrett-Byrne, D.A. ; Smyth, S.P. ; Bernstein, I.R. ; Anderson, A.L. ; Stanger, S.J. ; Simpson, E.N.A. ; Tomar, A. ; Teperino, R. ; Conine, C.C. ; De Iuliis, G.N. ; Roman, S.D. ; Bromfield, E.G. ; Dun, M.D. ; Eamens, A.L. ; Nixon, B.
Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice.Skerrett-Byrne, D.A. ; Teperino, R. ; Nixon, B.
ShinySperm: Navigating the sperm proteome landscape.Schäfer, F. ; Tomar, A. ; Sato, S. ; Teperino, R. ; Imhof, A. ; Lahiri, S.
Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS.
