Stem Cell Center Epigenetics and Stem Cells
At the Institute of Epigenetics and Stem Cells (IES), we aim to unlock a cell's full potential by understanding how a single cell can give rise to all the cells in our body at the beginning of life.
At the Institute of Epigenetics and Stem Cells (IES), we aim to unlock a cell's full potential by understanding how a single cell can give rise to all the cells in our body at the beginning of life.
IES members
Prof. Dr. Maria-Elena Torres-Padilla
Director of the Stem Cell Center, Director of the Institute for Epigenetics and Stem Cells, Group LeaderDr. Stephan Hamperl
Group LeaderDr. Antonio Scialdone
Group Leader
Dr. Nicolas Battich
Group LeaderDr. Jonathan Adam Burton
Deputy Head of Institute for Epigenetics and Stem CellsDr. Andreas Ettinger
Head of Microscopy CoreDr. Tamas Schauer
Senior Computational BiologistDr. Marlies Oomen
PostdocDr. Antoine Canat
PostdocDr. Maxime Lalonde
PostdocDr. Clare Shuk Kwan Lee
PostdocDr. Martin Miranda
PostdocDr. Federico Pecori
PostdocDr. Ioannis Tsirkas
PostdocDr. Jiezhen Mo
PostdocDr. Yuki Oyama
PostdocDr. José Terrón-Bautista
PostdocGabriele Lubatti
Doctoral ResearcherMeghana Oak
Doctoral ResearcherAna Janeva
Doctoral Researcher
Gofur Mohammad Wasiful
Doctoral ResearcherMarco Stock
Doctoral ResearcherVeronica Finazzi
Doctoral ResearcherYicong Chen
Doctoral ResearcherAtiqa Sajid
Doctoral ResearcherIliya Nadelson
Doctoral Researcher
David von Bonin
Doctoral ResearcherElizabeth Marquez Gomez
Research Assistant – BioinformaticsMargarita Cespedes Barroso
Lab ManagerXanthoula Karypidou
Lab ManagerMelissa Mayen Quiroz
InternThomas Gerling
Administrative AssistantLaura Grodtmann
Administrative AssistantDr. Pilar Okenve-Ramos
Scientific Coordinator for EpigeneticsLatest Publications
Read more2025 Review in Trends in Genetics
Nakatani, T.
Dynamics of replication timing during mammalian development.
2025 Scientific Article in Stem Cell Reports
Zikmund, T. ; Fiorentino, J. ; Penfold, C. ; Stock, M. ; Shpudeiko, P. ; Agarwal, G. ; Langfeld, L. ; Petrova, K. ; Peshkin, L. ; Hamperl, S. ; Scialdone, A. ; Hörmanseder, E.
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory.
2025 Scientific Article in Science Advances
Neupane, J. ; Lubatti, G. ; Gross-Thebing, T. ; Ruiz Tejada Segura, M.L. ; Butler, R.H. ; Gross-Thebing, S. ; Dietmann, S. ; Scialdone, A. ; Surani, M.A.
The emergence of human primordial germ cell-like cells in stem cell-derived gastruloids.
2025 Review in Nature Reviews - Genetics
Burton, A. ; Torres-Padilla, M.E.
Epigenome dynamics in early mammalian embryogenesis.
2025 Scientific Article in Developmental Cell
Nakatani, T. ; Schauer, T. ; Pal, M. ; Ettinger, A. ; Altamirano-Pacheco, L. ; Zorn, J. ; Gilbert, D.M. ; Torres-Padilla, M.E.
RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization.
2025 Scientific Article in Cell
Pal, M. ; Schauer, T. ; Burton, A. ; Nakatani, T. ; Pecori, F. ; Hernández-Giménez, A. ; Nadelson, I. ; Marti-Renom, M.A. ; Torres-Padilla, M.E.
The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways.
2025 Review in Science
Götz, M. ; Torres-Padilla, M.E.
Stem cells as role models for reprogramming and repair.
2025 Review in Molecular Systems Biology
Stock, M. ; Losert, C. ; Zambon, M. ; Popp, N. ; Lubatti, G. ; Hörmanseder, E. ; Heinig, M. ; Scialdone, A.
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data.
2025 Scientific Article in Nature Aging
Toghani, D. ; Gupte, S.C. ; Zeng, S. ; Mahammadov, E. ; Crosse, E.I. ; Seyedhassantehrani, N. ; Burns, C. ; Gravano, D. ; Radtke, S. ; Kiem, H.P. ; Rodriguez, S. ; Carlesso, N. ; Pradeep, A. ; Georgiades, A. ; Lucas, F. ; Wilson, N.K. ; Kinston, S.J. ; Göttgens, B. ; Zong, L. ; Beerman, I. ; Park, B. ; Janssens, D.H. ; Jones, D. ; Toghani, A. ; Nerlov, C. ; Pietras, E.M. ; Mesnieres, M. ; Maes, C. ; Kumanogoh, A. ; Worzfeld, T. ; Cheong, J.G. ; Josefowicz, S.Z. ; Kharchenko, P.V. ; Scadden, D.T. ; Scialdone, A. ; Spencer, J.A. ; Silberstein, L.
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.
2025 Scientific Article in Cell
Oomen, M.E. ; Rodriguez-Terrones, D. ; Kurome, M. ; Zakhartchenko, V. ; Mottes, L. ; Simmet, K. ; Noll, C. ; Nakatani, T. ; Mourra-Díaz, D.M. ; Aksoy, I. ; Savatier, P. ; Goke, J. ; Wolf, E. ; Kaessmann, H. ; Torres-Padilla, M.E.
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development.
2025 Scientific Article in Nucleic Acids Research
Werner, M. ; Trauner, M. ; Schauer, T. ; Ummethum, H. ; Márquez-Gómez, E. ; Lalonde, M. ; Lee, C.S.K. ; Tsirkas, I. ; Sajid, A. ; Murriello, A.C. ; Längst, G. ; Hamperl, S.
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
2025 Scientific Article in Genes and Development
Hermant, C. ; Mourra-Díaz, D.M. ; Oomen, M.E. ; Altamirano-Pacheco, L. ; Pal, M. ; Nakatani, T. ; Torres-Padilla, M.E.
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation.
2025 Nature Aging
Toghani, D. ; Gupte, S.C. ; Zeng, S. ; Mahammadov, E. ; Crosse, E.I. ; Seyedhassantehrani, N. ; Burns, C. ; Gravano, D. ; Radtke, S. ; Kiem, H.P. ; Rodriguez, S. ; Carlesso, N. ; Pradeep, A. ; Georgiades, A. ; Lucas, F. ; Wilson, N.K. ; Kinston, S.J. ; Göttgens, B. ; Zong, L. ; Beerman, I. ; Park, B. ; Janssens, D.H. ; Jones, D. ; Toghani, A. ; Nerlov, C. ; Pietras, E.M. ; Mesnieres, M. ; Maes, C. ; Kumanogoh, A. ; Worzfeld, T. ; Cheong, J.G. ; Josefowicz, S.Z. ; Kharchenko, P.V. ; Scadden, D.T. ; Scialdone, A. ; Spencer, J.A. ; Silberstein, L.
Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.
2024 Scientific Article in Genome Biology
Hains, A.E. ; Chetal, K. ; Nakatani, T. ; Marques, J.G. ; Ettinger, A. ; Junior, C.A.O.B. ; Gonzalez-Sandoval, A. ; Pillai, R. ; Filbin, M.G. ; Torres-Padilla, M.E. ; Sadreyev, R.I. ; Van Rechem, C.
Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy.
2024 Scientific Article in PLoS ONE
Arner, A. ; Ettinger, A. ; Blaser, B.W. ; Schmid, B. ; Jeremias, I. ; Rostam, N. ; Binder-Blaser, V.
In vivo monitoring of leukemia-niche interactions in a zebrafish xenograft model.
Contact
Laura Grodtmann
Administrative Assistant
- Telephone: +49 89 3187-43567
- E-mail: Email me