Veröffentlichungen 2025
Zhang, X. ; Harir, M. ; Schick, J.A. ; Lucio, M. ; Gomes, I.B. ; Simões, M.G. ; Schmitt-Kopplin, P.
Cell phenotyping reveals chemical water disinfection treatment-induced molecular and morphological perturbations.Graß, C. ; Ober, F. ; Sixt, C. ; Nemati Moud, B. ; Antoshkina, I. ; Eberstadt, F. ; Puhach, A. ; Avar, G. ; Keßler, A. ; O'Neill, T.J. ; Seeholzer, T. ; Kranich, J. ; Brocker, T. ; Lammens, K. ; Menden, M.P. ; Zielinski, C.E. ; Krappmann, D.
LUBAC modulates CBM complex functions downstream of TRAF6 in T cells.Kieser, A.
The latent membrane protein 1 (LMP1): Biological functions and molecular mechanisms.Peng, H. ; Pfeiffer, S. ; Varynskyi, B. ; Qiu, M. ; Srinark, C. ; Jin, X. ; Zhang, X. ; Williams, K. ; Groveman, B.R. ; Foliaki, S.T. ; Race, B. ; Thomas, T. ; Chen, C. ; Müller, C. ; Kovács, K.J. ; Arzberger, T. ; Momma, S. ; Haigh, C.L. ; Schick, J.A.
Prion-induced ferroptosis is facilitated by RAC3.Yang, Y. ; Peng, H. ; Meng, D. ; Fa, Z. ; Chen, Y. ; Lin, X. ; Schick, J.A. ; Jin, X.
Stress management: How the endoplasmic reticulum mitigates protein misfolding and oxidative stress by the dual role of glutathione peroxidase 8.Tschuck, J. ; Skafar, V. ; Friedmann Angeli, J.P. ; Hadian, K.
The metabolic code of ferroptosis: Nutritional regulators of cell death.Mishima, E. ; O'Neill, T.J. ; Hoefig, K.P. ; Chen, D. ; Behrens, G. ; Henkelmann, B. ; Ito, J. ; Nakagawa, K. ; Heissmeyer, V. ; Conrad, M. ; Krappmann, D.
MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4.Brvar, M. ; O'Neill, T.J. ; Plettenburg, O. ; Krappmann, D.
An updated patent review of MALT1 inhibitors (2021-present).Yin, H. ; Liu, T. ; Wu, D. ; Li, X. ; Li, G. ; Song, W. ; Wang, X. ; Xin, S. ; Liu, Y. ; Pan, J.
Exploring FAM13A-N-Myc interactions to uncover potential targets in MYCN-amplified neuroblastoma: A study of protein interactions and molecular dynamics simulations.Ramani, A. ; Pasquini, G. ; Gerkau, N.J. ; Jadhav, V. ; Vinchure, O.S. ; Altinisik, N. ; Windoffer, H. ; Muller, S. ; Rothenaigner, I. ; Lin, S. ; Mariappan, A. ; Rathinam, D. ; Mirsaidi, A. ; Goureau, O. ; Ricci-Vitiani, L. ; D'Alessandris, Q.G. ; Wollnik, B. ; Muotri, A. ; Freifeld, L. ; Jurisch-Yaksi, N. ; Pallini, R. ; Rose, C.R. ; Busskamp, V. ; Gabriel, E. ; Hadian, K. ; Gopalakrishnan, J.
Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.Veröffentlichungen 2024
Ramani, A. ; Pasquini, G. ; Gerkau, N.J. ; Jadhav, V. ; Vinchure, O.S. ; Altinisik, N. ; Windoffer, H. ; Müller, S. ; Rothenaigner, I. ; Lin, S. ; Mariappan, A. ; Rathinam, D. ; Mirsaidi, A. ; Goureau, O. ; Ricci-Vitiani, L. ; D'Alessandris, Q.G. ; Wollnik, B. ; Muotri, A. ; Freifeld, L. ; Jurisch-Yaksi, N. ; Pallini, R. ; Rose, C.R. ; Busskamp, V. ; Gabriel, E. ; Hadian, K. ; Gopalakrishnan, J.
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.Tschuck, J. ; Tonnus, W. ; Gavali, S. ; Kolak, A. ; Mallais, M. ; Maremonti, F. ; Sato, M. ; Rothenaigner, I. ; Friedmann Angeli, J.P. ; Pratt, D.A. ; Linkermann, A. ; Hadian, K.
Seratrodast inhibits ferroptosis by suppressing lipid peroxidation.Rosenlehner, T. ; Pennavaria, S. ; Akçabozan, B. ; Jahani, S. ; O'Neill, T.J. ; Krappmann, D. ; Straub, T. ; Kranich, J. ; Obst, R.
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells.Klinger, B. ; Rausch, I. ; Sieber, A. ; Kutz, H. ; Kruse, V. ; Kirchner, M. ; Mertins, P. ; Kieser, A. ; Blüthgen, N. ; Kube, D.
Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network.Dabbah-Krancher, G. ; Ruchinskas, A. ; Kallarakal, M.A. ; Lee, K.P. ; Bauman, B.M. ; Epstein, B. ; Yin, H. ; Krappmann, D. ; Schaefer, B.C. ; Snow, A.L.
A20 intrinsically influences human effector T-cell survival and function by regulating both NF-κB and JNK signaling.Tschuck, J. ; Padmanabhan Nair, V. ; Galhoz, A. ; Zaratiegui, C. ; Tai, H.-M. ; Ciceri, G. ; Rothenaigner, I. ; Tchieu, J. ; Stockwell, B.R. ; Studer, L. ; Cabianca, D.S. ; Menden, M.P. ; Vincendeau, M. ; Hadian, K.
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.Schum, D. ; Elsen, F.A.V. ; Ruddell, S. ; Schorpp, K. ; Junca, H. ; Müsken, M. ; Chen, S.Y. ; Fiedler, M.K. ; Pickl, T. ; Pieper, D.H. ; Hadian, K. ; Zacharias, M. ; Sieber, S.A.
Screening privileged alkyl Guanidinium motifs under host-mimicking conditions reveals a novel antibiotic with an unconventional mode of action.Yang, X. ; Forstner, M.E. ; Rothenaigner, I. ; Bullo, M. ; Şismanlar, T.E. ; Aslan, A.T. ; Latzin, P. ; Hadian, K. ; Griese, M.
Cyclosporine A in children with ABCA3 deficiency.Heine, S. ; Alessandrini, F. ; Grosch, J. ; Graß, C. ; Heldner, A. ; Schnautz, B. ; Buters, J.T.M. ; Slusarenko, B.O. ; Krappmann, D. ; Fallarino, F. ; Ohnmacht, C. ; Schmidt-Weber, C.B. ; Blank, S.
Activation of the aryl hydrocarbon receptor improves allergen-specific immunotherapy of murine allergic airway inflammation: A novel adjuvant option?Peng, H. ; Xin, S. ; Pfeiffer, S. ; Müller, C. ; Merl-Pham, J. ; Hauck, S.M. ; Harter, P.N. ; Spitzer, D. ; Devraj, K. ; Varynskyi, B. ; Arzberger, T. ; Momma, S. ; Schick, J.A.
Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia.Nemati Moud, B. ; Ober, F. ; O'Neill, T.J. ; Krappmann, D.
MALT1 substrate cleavage: What is it good for?Gottemukkala, K.V. ; Chrustowicz, J. ; Sherpa, D. ; Sepic, S. ; Vu, D.T. ; Karayel, Ö. ; Papadopoulou, E.C. ; Gross, A. ; Schorpp, K. ; von Gronau, S. ; Hadian, K. ; Murray, P.J. ; Mann, M. ; Schulman, B.A. ; Alpi, A.F.
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.Varynskyi, B. ; Schick, J.A.
Hacking the lipidome: New ferroptosis strategies in cancer therapy.Giehler, F. ; Ostertag, M.S. ; Sommermann, T. ; Weidl, D. ; Sterz, K. ; Kutz, H. ; Moosmann, A. ; Feller, S.M. ; Geerlof, A. ; Biesinger, B. ; Popowicz, G.M. ; Kirchmair, J. ; Kieser, A.
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.Tofaute, M.J. ; Weller, B. ; Graß, C. ; Halder, H. ; Dohai, B.S.M. ; Falter-Braun, P. ; Krappmann, D.
SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation.Veröffentlichungen 2023
Graß, C.
Functional and mechanistic insights into MALT1-mediated regulation of immune homeostasis.Schmidt, H. ; Raj, T. ; O´Neill, T.J. ; Muschaweckh, A. ; Giesert, F. ; Negraschus, A. ; Hoefig, K.P. ; Behrens, G. ; Esser, L. ; Baumann, Christina ; Feederle, R. ; Plaza-Sirvent, C. ; Geerlof, A. ; Gewies, A. ; Isay, S.E. ; Ruland, J. ; Schmitz, I. ; Wurst, W. ; Korn, T. ; Krappmann, D. ; Heissmeyer, V.
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.Spella, M. ; Ntaliarda, G. ; Skiadas, G. ; Lamort, A.-S. ; Vreka, M. ; Marazioti, A. ; Lilis, I. ; Bouloukou, E. ; Giotopoulou, G.A. ; Pepe, M. ; Weiss, S.A. ; Petrera, A. ; Hauck, S.M. ; Koch, I. ; Lindner, M. ; Hatz, R.A. ; Behr, J. ; Arendt, K.A.M. ; Giopanou, I. ; Brunn, D. ; Savai, R. ; Jenne, D. ; de Château, M. ; Yull, F.E. ; Blackwell, T.S. ; Stathopoulos, G.T.
Non-oncogene addiction of KRAS-mutant cancers to IL-1β via versican and mononuclear IKKβ.O'Neill, T.J. ; Tofaute, M.J. ; Krappmann, D.
Function and targeting of MALT1 paracaspase in cancer.Di Pilato, M. ; Gao, Y. ; Sun, Y. ; Fu, A. ; Grass, C. ; Seeholzer, T. ; Feederle, R. ; Mazo, I. ; Kazer, S.W. ; Litchfield, K. ; von Andrian, U.H. ; Mempel, T.R. ; Jenkins, R.W. ; Krappmann, D. ; Keller, P.
Translational studies using the MALT1 inhibitor (S)-mepazine to induce Treg fragility and potentiate immune checkpoint therapy in cancer.Wimberger, N. ; Ober, F. ; Avar, G. ; Grau, M. ; Xu, W. ; Lenz, G. ; Menden, M.P. ; Krappmann, D.
Oncogene-induced MALT1 protease activity drives post-transcriptional gene expression in malignant lymphomas.O’Neill, T.J. ; Gewies, A. ; Seeholzer, T. ; Krappmann, D.
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.Chao, Y.Y. ; Puhach, A. ; Frieser, D. ; Arunkumar, M. ; Lehner, L. ; Seeholzer, T. ; Garcia-Lopez, A. ; van der Wal, M. ; Fibi-Smetana, S. ; Dietschmann, A. ; Sommermann, T. ; Cikovic, T. ; Taher, L. ; Gresnigt, M.S. ; Vastert, S.J. ; van Wijk, F. ; Panagiotou, G. ; Krappmann, D. ; Groß, O. ; Zielinski, C.E.
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.Kim, D.-K. ; Weller, B. ; Lin, C.-W. ; Sheykhkarimli, D. ; Knapp, J.J. ; Dugied, G. ; Zanzoni, A. ; Pons, C. ; Tofaute, M.J. ; Maseko, S.B. ; Spirohn, K. ; Laval, F. ; Lambourne, L. ; Kishore, N. ; Rayhan, A. ; Sauer, M. ; Young, V. ; Halder, H. ; Marin De La Rosa, N.A. ; Pogoutse, O. ; Strobel, A. ; Schwehn, P. ; Li, R. ; Rothballer, S.T. ; Altmann, M. ; Cassonnet, P. ; Coté, A.G. ; Elorduy Vergara, L. ; Hazelwood, I. ; Liu, B.B. ; Nguyen, M. ; Pandiarajan, R. ; Dohai, B.S.M. ; Rodriguez, P.A. ; Poirson, J. ; Giuliana, P. ; Willems, L. ; Taipale, M. ; Jacob, Y. ; Hao, T. ; Hill, D.E. ; Brun, C. ; Twizere, J.C. ; Krappmann, D. ; Heinig, M. ; Falter, C. ; Aloy, P. ; Demeret, C. ; Vidal, M. ; Calderwood, M.A. ; Roth, F.B. ; Falter-Braun, P.
A proteome-scale map of the SARS-CoV-2-human contactome.Veröffentlichungen 2022
Napolitano, V. ; Mroz, P. ; Marciniak, M. ; Kalel, V.C. ; Softley, C. ; Janna Olmos, J.D. ; Tippler, B.G. ; Schorpp, K.K. ; Rioton, S. ; Fröhlich, T. ; Plettenburg, O. ; Hadian, K. ; Erdmann, R. ; Sattler, M. ; Popowicz, G.M. ; Dawidowski, M. ; Dubin, G.
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.Kupczyk, E. ; Schorpp, K.K. ; Hadian, K. ; Lin, S. ; Tziotis, D. ; Schmitt-Kopplin, P. ; Müller, C.
Unleashing high content screening in hit detection - Benchmarking AI workflows including novelty detection.Kessler, N. ; Viehmann, S.F. ; Krollmann, C. ; Mai, K. ; Kirschner, K.M. ; Luksch, H. ; Kotagiri, P. ; Böhner, A.M.C. ; Huugen, D. ; de Oliveira Mann, C.C. ; Otten, S. ; Weiss, S.A. ; Zillinger, T. ; Dobrikova, K. ; Jenne, D. ; Behrendt, R. ; Ablasser, A. ; Bartok, E. ; Hartmann, G. ; Hopfner, K.P. ; Lyons, P.A. ; Boor, P. ; Rosen-Wolff, A. ; Teichmann, L.L. ; Heeringa, P. ; Kurts, C. ; Garbi, N.
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.Napolitano, V. ; Softley, C. ; Blat, A. ; Kalel, V.C. ; Schorpp, K.K. ; Siebenmorgen, T. ; Hadian, K. ; Erdmann, R. ; Sattler, M. ; Popowicz, G.M. ; Dubin, G.
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.Mempel, T.R. ; Krappmann, D.
Combining precision oncology and immunotherapy by targeting the MALT1 protease.O'Neill, T.J. ; Krappmann, D. ; Gewies, A.
Optimized CRISPR-Cas9-based strategy for complex gene targeting in murine embryonic stem cells for germline transmission.Jones, A. ; Grass, C. ; Meininger, I. ; Geerlof, A. ; Klostermann, M. ; Zarnack, K. ; Krappmann, D. ; Sattler, M.
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.Rothenaigner, I. ; Brenke, J.K. ; Schorpp, K.K. ; Hadian, K.
Methods to detect small molecule inhibition of RING E3 ligase activity.Kutzner, K. ; Woods, S. ; Karayel, O. ; Gehring, T. ; Yin, H. ; Flatley, A. ; Grass, C. ; Wimberger, N. ; Tofaute, M.J. ; Seeholzer, T. ; Feederle, R. ; Mann, M. ; Krappmann, D.
Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells.Jin, J. ; Schorpp, K.K. ; Samaga, D. ; Unger, K. ; Hadian, K. ; Stockwell, B.R.
Machine learning classifies ferroptosis and apoptosis cell death modalities with TfR1 immunostaining.Hong, L. ; Li, N. ; Gasque, V. ; Mehta, S. ; Ye, L. ; Wu, Y. ; Li, J. ; Gewies, A. ; Ruland, J. ; Hirschi, K.K. ; Eichmann, A. ; Hendry, C. ; van Dijk, D. ; Mani, A.
Prdm6 controls heart development by regulating neural crest cell differentiation and migration.Sefer, A.P. ; Abolhassani, H. ; Ober, F. ; Kayaoglu, B. ; Bilgic Eltan, S. ; Kara, A. ; Erman, B. ; Surucu Yilmaz, N. ; Aydogmus, C. ; Aydemir, S. ; Charbonnier, L.M. ; Kolukisa, B. ; Azizi, G. ; Delavari, S. ; Momen, T. ; Aliyeva, S. ; Kendir Demirkol, Y. ; Tekin, S. ; Kiykim, A. ; Baser, O.F. ; Cokugras, H. ; Gursel, M. ; Karakoc-Aydiner, E. ; Ozen, A. ; Krappmann, D. ; Chatila, T.A. ; Rezaei, N. ; Baris, S.
Expanding the clinical and immunological phenotypes and natural history of MALT1 deficiency.Yin, H. ; Karayel, O. ; Chao, Y.Y. ; Seeholzer, T. ; Hamp, I. ; Plettenburg, O. ; Gehring, T. ; Zielinski, C. ; Mann, M. ; Krappmann, D.
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.Napolitano, V. ; Dabrowska, A. ; Schorpp, K.K. ; Mourao, A. ; Barreto-Duran, E. ; Benedyk, M. ; Botwina, P. ; Brandner, S. ; Bostock, M.J. ; Chykunova, Y. ; Czarna, A. ; Dubin, G. ; Fröhlich, T. ; Hölscher, M. ; Jedrysik, M. ; Matsuda, A. ; Owczarek, K. ; Pachota, M. ; Plettenburg, O. ; Potempa, J.S. ; Rothenaigner, I. ; Schlauderer, F. ; Slysz, K. ; Szczepanski, A. ; Greve-Isdahl Mohn, K. ; Blomberg, B. ; Sattler, M. ; Hadian, K. ; Popowicz, G.M. ; Pyrc, K.
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.Amar, Y. ; Schneider, E. ; Köberle, M. ; Seeholzer, T. ; Musiol, S. ; Hölge, I.M. ; Gschwendtner, S. ; Krappmann, D. ; Steiger, K. ; Biedermann, T. ; Schmidt-Weber, C.B. ; Alessandrini, F.
Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro-inflammatory cytokines IL-4, IL-33 and TSLP.Popowicz, G.M. ; Pyrc, K. ; Hadian, K.
Vaccination versus SARS-CoV-2 Omicron: Three vaccine doses win the battle.Iturbide Martinez De Albeniz, A. ; Ruiz Tejada Segura, M.L. ; Noll, C. ; Schorpp, K.K. ; Rothenaigner, I. ; Lubatti, G. ; Agami, A. ; Hadian, K. ; Scialdone, A. ; Torres-Padilla, M.E.
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development.Bauer, A. ; Puglisi, M. ; Nagl, D. ; Schick, J. ; Werner, T. ; Klingl, A. ; El Andari, J. ; Hornung, V. ; Kessler, H. ; Götz, M. ; Grimm, D. ; Brack-Werner, R.
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.Forstner, M. ; Lin, S. ; Yang, X. ; Kinting, S. ; Rothenaigner, I. ; Schorpp, K.K. ; Li, Y. ; Hadian, K. ; Griese, M.
High-content screen identifies cyclosporin A as a novel ABCA3-specific molecular corrector.Lee, J.L. ; Ekambaram, P. ; Carleton, N.M. ; Hu, D. ; Klei, L.R. ; Cai, Z. ; Myers, M.I. ; Hubel, N.E. ; Covic, L. ; Agnihotri, S. ; Krappmann, D. ; Bornancin, F. ; Lee, A.V. ; Oesterreich, S. ; McAllister-Lucas, L.M. ; Lucas, P.C.
MALT1 is a targetable driver of epithelial-to-mesenchymal transition in claudin-low, triple-negative breast cancer.Xin, S. ; Müller, C. ; Pfeiffer, S. ; Kraft, V. ; Merl-Pham, J. ; Bao, X. ; Feederle, R. ; Jin, X. ; Hauck, S.M. ; Schmitt-Kopplin, P. ; Schick, J.
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling.Veröffentlichungen 2021
Keller, P. ; Mazo, I. ; Gao, Y. ; Reddy, V. ; Caballero, F. ; Kazer, S. ; Fu, A. ; Sun, Y. ; Miller, D. ; Gianani, R. ; Marvin, J. ; Stephens, B. ; Beatty, G. ; Jenkins, R. ; von Andrian, U. ; Krappmann, D. ; Mempel, T.
Reprogramming regulatory T cells (TREG) using a MALT1 inhibitor for cancer therapy.Gerckens, M. ; Schorpp, K.K. ; Pelizza, F. ; Wögrath, M. ; Reichau, K. ; Ma, H. ; Dworsky, A.-M. ; Sengupta, A. ; Stoleriu, M.-G. ; Heinzelmann, K. ; Merl-Pham, J. ; Irmler, M. ; Alsafadi, H.N. ; Trenkenschuh, E. ; Sarnova, L. ; Jirouskova, M. ; Frieß, W. ; Hauck, S.M. ; Beckers, J. ; Kneidinger, N. ; Behr, J. ; Hilgendorff, A. ; Hadian, K. ; Lindner, M. ; Königshoff, M. ; Eickelberg, O. ; Gregor, M. ; Plettenburg, O. ; Yildirim, A.Ö. ; Burgstaller, G.
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.Marazioti, A. ; Krontira, A.C. ; Behrend, S.J. ; Giotopoulou, G.A. ; Ntaliarda, G. ; Blanquart, C. ; Bayram, H. ; Iliopoulou, M. ; Vreka, M. ; Trassl, L. ; Pepe, M. ; Hackl, C.M. ; Klotz, L.V. ; Weiss, S.A. ; Koch, I. ; Lindner, M. ; Hatz, R.A. ; Behr, J. ; Wagner, D.E. ; Papadaki, H. ; Antimisiaris, S.G. ; Jean, D. ; Deshayes, S. ; Grégoire, M. ; Kayalar, ; Mortazavi, D. ; Dilege, ; Tanju, S. ; Erus, S. ; Yavuz, Ö. ; Bulutay, P. ; Fırat, P. ; Psallidas, I. ; Spella, M. ; Giopanou, I. ; Lilis, I. ; Lamort, A.-S. ; Stathopoulos, G.T.
KRAS signaling in malignant pleural mesothelioma.Hofmann, C. ; Sander, A. ; Wang, X.X. ; Buerge, M. ; Jungwirth, B. ; Borgstedt, L. ; Kreuzer, M. ; Kopp, C. ; Schorpp, K.K. ; Hadian, K. ; Wotjak, C.T. ; Ebert, T. ; Ruitenberg, M. ; Parsons, C.G. ; Rammes, G.
Inhalational anesthetics do not deteriorate amyloid-β-derived pathophysiology in alzheimer's disease: Investigations on the molecular, neuronal, and behavioral level.O'Neill, T.J. ; Seeholzer, T. ; Gewies, A. ; Gehring, T. ; Giesert, F. ; Hamp, I. ; Grass, C. ; Schmidt, H. ; Kriegsmann, K. ; Tofaute, M.J. ; Demski, K. ; Poth, T. ; Rosenbaum, M. ; Schnalzger, T. ; Ruland, J. ; Göttlicher, M. ; Kriegsmann, M. ; Naumann, R. ; Heissmeyer, V. ; Wurst, W. ; Krappmann, D.
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.Ghosh, D. ; Koch, U. ; Hadian, K. ; Sattler, M. ; Tetko, I.V.
Highly accurate filters to flag frequent hitters in alphascreen assays by suggesting their mechanism.Hadian, K. ; Stockwell, B.R.
A roadmap to creating ferroptosis-based medicines.Goranci-Buzhala, G. ; Mariappan, A. ; Ricci-Vitiani, L. ; Josipovic, N. ; Pacioni, S. ; Gottardo, M. ; Ptok, J. ; Schaal, H. ; Callaini, G. ; Rajalingam, K. ; Dynlacht, B.D. ; Hadian, K. ; Papantonis, A. ; Pallini, R. ; Gopalakrishnan, J.
Cilium induction triggers differentiation of glioma stem cells.Gewies, A. ; Grass, C. ; Krappmann, D.
Methods to study CARD11-BCL10-MALT1 dependent canonical NF-κB activation in jurkat T cells.Hamp, I. ; O'Neill, T.J. ; Plettenburg, O. ; Krappmann, D.
A patent review of MALT1 inhibitors (2013-present).Iturbide Martinez De Albeniz, A. ; Ruiz Tejada Segura, M.L. ; Noll, C. ; Schorpp, K.K. ; Rothenaigner, I. ; Ruiz-Morales, E.R. ; Lubatti, G. ; Agami, A. ; Hadian, K. ; Scialdone, A. ; Torres-Padilla, M.E.
Retinoic acid signaling is critical during the totipotency window in early mammalian development.Costa, R. ; Wagner, D.E. ; Doryab, A. ; De Santis, M.M. ; Schorpp, K.K. ; Rothenaigner, I. ; Lehmann, M. ; Baarsma, H.A. ; Liu, X. ; Schmid, O. ; Campillos, M.J. ; Yildirim, A.Ö. ; Hadian, K. ; Königshoff, M.
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation.Song, W. ; Xin, S. ; He, M. ; Pfeiffer, S. ; Cao, A. ; Li, H. ; Schick, J. ; Jin, X.
Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells.Rothenaigner, I. ; Hadian, K.
Brief Guide: Experimental strategies for high-quality hit selection from small-molecule screening campaigns.Padmanabhan Nair, V. ; Liu, H. ; Ciceri, G. ; Jungverdorben, J. ; Frishman, G. ; Tchieu, J. ; Cederquist, G.Y. ; Rothenaigner, I. ; Schorpp, K.K. ; Klepper, L. ; Walsh, R.M. ; Kim, T.W. ; Cornacchia, D. ; Ruepp, A. ; Mayer, J. ; Hadian, K. ; Frishman, D. ; Studer, L. ; Vincendeau, M.
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.Volmar, M.N.M. ; Cheng, J. ; Alenezi, H. ; Richter, S. ; Haug, A. ; Hassan, Z. ; Goldberg, M. ; Li, Y. ; Hou, M. ; Herold-Mende, C. ; Maire, C.L. ; Lamszus, K. ; Flüh, C. ; Held-Feindt, J. ; Gargiulo, G. ; Topping, G.J. ; Schilling, F. ; Saur, D. ; Schneider, G. ; Synowitz, M. ; Schick, J. ; Kälin, R.E. ; Glass, R.
Cannabidiol converts NFκB into a tumor suppressor in glioblastoma with defined antioxidative properties.Dahlin, J.L. ; Auld, D.S. ; Rothenaigner, I. ; Haney, S. ; Sexton, J.Z. ; Nissink, J.W.M. ; Walsh, J. ; Lee, J.A. ; Strelow, J.M. ; Willard, F.S. ; Ferrins, L. ; Baell, J.B. ; Walters, M.A. ; Hua, B.K. ; Hadian, K. ; Wagner, B.K.
Nuisance compounds in cellular assays.Weiss, S.A. ; Rehm, S.R.T. ; Perera, N.C. ; Biniossek, M.L. ; Schilling, O. ; Jenne, D.
Origin and expansion of the serine protease repertoire in the myelomonocyte lineage.Birling, M.C. ; Yoshiki, A. ; Adams, D.J. ; Ayabe, S. ; Beaudet, A.L. ; Bottomley, J. ; Bradley, A. ; Brown, S.D.M. ; Bürger, A. ; Bushell, W. ; Chiani, F. ; Chin, H.G. ; Christou, S. ; Codner, G.F. ; DeMayo, F.J. ; Dickinson, M.E. ; Doe, B. ; Donahue, L.R. ; Fray, M.D. ; Gambadoro, A. ; Gao, X. ; Gertsenstein, M. ; Gomez-Segura, A. ; Goodwin, L.O. ; Heaney, J.D. ; Hérault, Y. ; Hrabě de Angelis, M. ; Jiang, S.T. ; Justice, M.J. ; Kasparek, P. ; King, R.E. ; Kühn, R. ; Lee, H. ; Lee, Y.J. ; Liu, Z. ; Lloyd, K.C.K. ; Lorenzo, I. ; Mallon, A.M. ; McKerlie, C. ; Meehan, T.F. ; Fuentes, V.M. ; Newman, S. ; Nutter, L.M.J. ; Oh, G.T. ; Pavlovic, G. ; Ramirez-Solis, R. ; Rosen, B. ; Ryder, E.J. ; Santos, L.A. ; Schick, J. ; Seavitt, J.R. ; Sedlacek, R. ; Seisenberger, C. ; Seong, J.K. ; Skarnes, W.C. ; Sorg, T. ; Steel, K.P. ; Tamura, M. ; Tocchini-Valentini, G.P. ; Wang, C.L. ; Wardle-Jones, H. ; Wattenhofer-Donzé, M. ; Wells, S. ; Wiles, M.V. ; Willis, B.J. ; Wood, J.A. ; Wurst, W. ; Xu, Y. ; Teboul, L. ; Murray, S.A. ; IMPC Consortium (Gailus-Durner, V. ; Fuchs, H. ; Marschall, S.)
A resource of targeted mutant mouse lines for 5,061 genes.Zhou, F. ; Zheng, B. ; Wang, F. ; Cao, A. ; Xie, S. ; Chen, X. ; Schick, J. ; Jin, X. ; Li, H.
Genome-wide analysis of MDHAR gene family in four cotton species provides insights into fiber development via regulating AsA redox homeostasis.Weber, E. ; Schorpp, K.K. ; Hadian, K.
Studying OTUD6B-OTUB1 protein-protein interaction by low-throughput GFP-trap assays and high-throughput AlphaScreen assays.Hartleben, G. ; Schorpp, K.K. ; Kwon, Y. ; Betz, B. ; Tsokanos, F.-F. ; Dantes, Z. ; Schäfer, A. ; Rothenaigner, I. ; Monroy Kuhn, J.M. ; Morigny, P. ; Mehr, L. ; Lin, S. ; Seitz, S. ; Tokarz, J. ; Artati, A. ; Adamski, J. ; Plettenburg, O. ; Lutter, D. ; Irmler, M. ; Beckers, J. ; Reichert, M. ; Hadian, K. ; Zeigerer, A. ; Herzig, S. ; Berriel Diaz, M.
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.Karlina, R. ; Lutter, D. ; Miok, V. ; Fischer, D.S. ; Altun, I. ; Schöttl, T. ; Schorpp, K.K. ; Israel, A. ; Cero, C. ; Johnson, J.W. ; Kapser-Fischer, I. ; Böttcher, A. ; Keipert, S. ; Feuchtinger, A. ; Graf, E. ; Strom, T.M. ; Walch, A.K. ; Lickert, H. ; Walzthoeni, T. ; Heinig, M. ; Theis, F.J. ; García-Cáceres, C. ; Cypess, A.M. ; Ussar, S.
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice.Kutukculer, N. ; Seeholzer, T. ; O'Neill, T.J. ; Grass, C. ; Aykut, A. ; Karaca, N.E. ; Durmaz, A. ; Cogulu, O. ; Aksu, G. ; Gehring, T. ; Gewies, A. ; Krappmann, D.
Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant.Veröffentlichungen 2020
Jagtap, P.K. ; Kubelka, T. ; Soni, K. ; Will, C.L. ; Garg, D. ; Sippel, C. ; Kapp, T.G. ; Potukuchi, H.K. ; Schorpp, K.K. ; Hadian, K. ; Kessler, H. ; Lührmann, R. ; Hausch, F. ; Bach, T. ; Sattler, M.
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.Li, Z. ; He, P. ; Luo, G. ; Shi, X. ; Yuan, G. ; Zhang, B. ; Seidl, C. ; Gewies, A. ; Wang, Y. ; Zou, Y. ; Long, Y. ; Yue, D. ; Zhang, X.
Increased tumoral microenvironmental pH improves cytotoxic effect of pharmacologic ascorbic acid in castration-resistant prostate cancer cells.Selmansberger, M. ; Michna, A. ; Braselmann, H. ; Höfig, I. ; Schorpp, K.K. ; Weber, P. ; Anastasov, N. ; Zitzelsberger, H. ; Hess J. ; Unger, K.
Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.Lin, S. ; Schorpp, K.K. ; Rothenaigner, I. ; Hadian, K.
Image-based high-content screening in drug discovery.Yang, L. ; Kraft, V. ; Pfeiffer, S. ; Merl-Pham, J. ; Bao, X. ; An, Y. ; Hauck, S.M. ; Schick, J.
Nonsense-mediated decay factor SMG7 sensitizes cells to TNF alpha-induced apoptosis via CYLD tumor suppressor and the noncoding oncogenePvt1.Coussens, N.P. ; Auld, D. ; Roby, P. ; Walsh, J. ; Baell, J.B. ; Kales, S. ; Hadian, K. ; Dahlin, J.L.
Compound-mediated assay interferences in homogenous proximity assays.Fischer, A. ; Koopmans, T. ; Ramesh, P. ; Christ, S. ; Strunz, M. ; Wannemacher, J. ; Aichler, M. ; Feuchtinger, A. ; Walch, A.K. ; Ansari, M. ; Theis, F.J. ; Schorpp, K.K. ; Hadian, K. ; Neumann, P.A. ; Schiller, H. B. ; Rinkevich, Y.
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces.Hadian, K. ; Stockwell, B.R.
SnapShot: Ferroptosis.van de Plassche, M.A.T. ; O'Neill, T.J. ; Seeholzer, T. ; Turk, B. ; Krappmann, D. ; Verhelst, S.H.L.
Use of non-natural amino acids for the design and synthesis of a selective, cell-permeable MALT1 activity-based probe.Stubbe, M. ; Mai, J. ; Paulus, C. ; Stubbe, H.C. ; Berscheminski, J. ; Karimi, M. ; Hofmann, S. ; Weber, E. ; Hadian, K. ; Hay, R. ; Groitl, P. ; Nevels, M. ; Dobner, T. ; Schreiner, S.
Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers.Feng, H. ; Schorpp, K.K. ; Jin, J. ; Yozwiak, C.E. ; Hoffstrom, B.G. ; Decker, A.M. ; Rajbhandari, P. ; Stokes, M.E. ; Bender, H.G. ; Csuka, J.M. ; Upadhyayula, P.S. ; Canoll, P. ; Uchida, K. ; Soni, R.K. ; Hadian, K. ; Stockwell, B.R.
Transferrin receptor is a specific ferroptosis marker.Voigt, S. ; Sterz, K. ; Giehler, F. ; Mohr, A.-W. ; Wilson, J.B. ; Moosmann, A. ; Kieser, A.
A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation.Cacheiro, P. ; Muñoz-Fuentes, V. ; Murray, S.A. ; Dickinson, M.E. ; Bucan, M. ; Nutter, L.M.J. ; Peterson, K.A. ; Haselimashhadi, H. ; Flenniken, A.M. ; Morgan, H. ; Westerberg, H. ; Konopka, T. ; Hsu, C.W. ; Christiansen, A.V. ; Lanza, D.G. ; Beaudet, A.L. ; Heaney, J.D. ; Fuchs, H. ; Gailus-Durner, V. ; Sorg, T. ; Prochazka, J. ; Novosadova, V. ; Lelliott, C.J. ; Wardle-Jones, H. ; Wells, S. ; Teboul, L. ; Cater, H. ; Stewart, M. ; Hough, T. ; Wurst, W. ; Sedlacek, R. ; Adams, D.J. ; Seavitt, J.R. ; Tocchini-Valentini, G. ; Mammano, F. ; Braun, R.E. ; McKerlie, C. ; Herault, Y. ; Hrabě de Angelis, M. ; Mallon, A.M. ; Lloyd, K.C.K. ; Brown, S.D.M. ; Parkinson, H. ; Meehan, T.F. ; Smedley, D. ; International Mouse Phenotyping Consortium (Marschall, S. ; Lengger, C. ; Maier, H. ; Seisenberger, C. ; Bürger, A. ; Kühn, R. ; Schick, J. ; Hörlein, A. ; Oritz, O. ; Giesert, F. ; Beig, J.)
Human and mouse essentiality screens as a resource for disease gene discovery.Hadian, K.
Ferroptosis suppressor protein 1 (FSP1) and coenzyme Q(10) cooperatively suppress ferroptosis.Minina, E.A. ; Staal, J. ; Alvarez, V.E. ; Berges, J.A. ; Berman-Frank, I. ; Beyaert, R. ; Bidle, K.D. ; Bornancin, F. ; Casanova, M. ; Cazzulo, J.J. ; Choi, C.J. ; Coll, N.S. ; Dixit, V.M. ; Dolinar, M. ; Fasel, N. ; Funk, C. ; Gallois, P. ; Gevaert, K. ; Gutierrez-Beltran, E. ; Hailfinger, S. ; Klemenčič, M. ; Koonin, E.V. ; Krappmann, D. ; Linusson, A. ; Machado, M.F.M. ; Madeo, F. ; Megeney, L.A. ; Moschou, P.N. ; Mottram, J.C. ; Nyström, T. ; Osiewacz, H.D. ; Overall, C.M. ; Pandey, K.C. ; Ruland, J. ; Salvesen, G.S. ; Shi, Y. ; Smertenko, A. ; Stael, S. ; Ståhlberg, J. ; Suárez, M.F. ; Thome, M. ; Tuominen, H. ; van Breusegem, F. ; van der Hoorn, R.A.L. ; Vardi, A. ; Zhivotovsky, B. ; Lam, E. ; Bozhkov, P.V.
Classification and nomenclature of metacaspases and paracaspases: No more confusion with caspases.Torres-Mejia, E. ; Trümbach, D. ; Kleeberger, C. ; Dornseifer, U. ; Orschmann, T. ; Bäcker, T. ; Brenke, J.K. ; Hadian, K. ; Wurst, W. ; López-Schier, H. ; Desbordes, S.C.
Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis.Dawidowski, M. ; Kalel, V.C. ; Napolitano, V. ; Fino, R. ; Schorpp, K.K. ; Emmanouilidis, L. ; Lenhart, D. ; Ostertag, M.S. ; Kaiser, M. ; Kolonko, M. ; Tippler, B. ; Schliebs, W. ; Dubin, G. ; Mäser, P. ; Tetko, I.V. ; Hadian, K. ; Plettenburg, O. ; Erdmann, R. ; Sattler, M. ; Popowicz, G.M.
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity.Kraft, V. ; Bezjian, C.T. ; Pfeiffer, S. ; Ringelstetter, L. ; Müller, C. ; Zandkarimi, F. ; Merl-Pham, J. ; Bao, X. ; Anastasov, N. ; Kössl, J. ; Brandner, S. ; Daniels, J.D. ; Schmitt-Kopplin, P. ; Hauck, S.M. ; Stockwell, B.R. ; Hadian, K. ; Schick, J.
GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling.Veröffentlichungen 2019
Volmar, M. ; Nagl, B. ; Haug, A. ; Richter, S. ; Alenezi, H. ; Herold-Mende, C. ; Lamszus, K. ; Synowitz, M. ; Schick, J. ; Kalin, R. ; Glass, R.
RelA-activity is essential for cannabidiol-mediated cytotoxicity in an identified subset of glioblastoma.Gehring, T. ; Erdmann, T. ; Rahm, M. ; Grass, C. ; Flatley, A. ; O´Neill, T.J. ; Woods, S. ; Meininger, I. ; Karayel, O. ; Kutzner, K. ; Grau, M. ; Shinohara, H. ; Lammens, K. ; Feederle, R. ; Hauck, S.M. ; Lenz, G. ; Krappmann, D.
MALT1 phosphorylation controls activation of T lymphocytes and survival of ABC-DLBCL tumor cells.Stangl, A. ; Elliott, P.R. ; Pinto-Fernandez, A. ; Bonham, S. ; Harrison, L. ; Schaub, A. ; Kutzner, K. ; Keusekotten, K ; Pfluger, P.T. ; El Oualid, F. ; Kessler, B.M. ; Komander, D. ; Krappmann, D.
Regulation of the endosomal SNX27-retromer by OTULIN.Wagner, A. ; Hofmeister, O. ; Rolland, S.G. ; Maiser, A. ; Aasumets, K. ; Schmitt, S. ; Schorpp, K.K. ; Feuchtinger, A. ; Hadian, K. ; Schneider, S. ; Zischka, H. ; Leonhardt, H. ; Conradt, B. ; Gerhold, J.M. ; Wolf, A.
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.Vrzalikova, K. ; Ibrahim, M. ; Vockerodt, M. ; Perry, T. ; Margielewska, S. ; Lupino, L. ; Nagy, E. ; Soilleux, E. ; Liebelt, D. ; Hollows, R. ; Last, A. ; Reynolds, G. ; Abdullah, M. ; Curley, H. ; Care, M. ; Krappmann, D. ; Tooze, R. ; Allegood, J. ; Spiegel, S. ; Wei, W. ; Woodman, C.B.J. ; Murray, P.G.
S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells (vol 32, pg 214, 2018).Rosenbaum, M. ; Gewies, A. ; Pechloff, K. ; Heuser, C. ; Engleitner, T. ; Gehring, T. ; Hartjes, L. ; Krebs, S. ; Krappmann, D. ; Kriegsmann, M. ; Weichert, W. ; Rad, R. ; Kurts, C. ; Ruland, J.
Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.Cho, J.J. ; Xu, Z. ; Parthasarathy, U. ; Drashansky, T.T. ; Helm, E.Y. ; Zuniga, A.N. ; Lorentsen, K.J. ; Mansouri, S. ; Cho, J.Y. ; Edelmann, M.J. ; Duong, D.M. ; Gehring, T. ; Seeholzer, T. ; Krappmann, D. ; Uddin, M.N. ; Califano, D. ; Wang, R.L. ; Jin, L. ; Li, H. ; Lv, D. ; Zhou, D. ; Zhou, L. ; Avram, D.
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.Vockerodt, M. ; Vrzalikova, K. ; Ibrahim, M. ; Nagy, E. ; Margielewska, S. ; Hollows, R. ; Lupino, L. ; Tooze, R. ; Care, M. ; Simmons, W. ; Schrader, A. ; Perry, T. ; Abdullah, M. ; Foster, S. ; Reynolds, G. ; Dowell, A. ; Rudski, Z. ; Krappmann, D. ; Kube, D. ; Woodman, C. ; Wei, W. ; Taylor, G. ; Murray, P.G.
Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma.Mariappan, A. ; Soni, K. ; Schorpp, K.K. ; Zhao, F. ; Minakar, A. ; Zheng, X. ; Mandad, S. ; Macheleidt, I. ; Ramani, A. ; Kubelka, T. ; Dawidowski, M. ; Golfmann, K. ; Wason, A. ; Yang, C. ; Simons, J. ; Schmalz, H.G. ; Hyman, A.A. ; Aneja, R. ; Ullrich, R. ; Urlaub, H. ; Odenthal, M. ; Büttner, R. ; Li, H. ; Sattler, M. ; Hadian, K. ; Gopalakrishnan, J.
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.