Niessing Lab
Our main interest is to understand principles of RNA-mediated gene regulation and its contribution to pathologies. Our research tools include structural biology and biophysics, RNA and protein biochemistry as well as various aspects of cell biology. In addition, we run the X-ray crystallography platform at HMGU. Furthermore, we are also closely interacting with our partner lab at the Ulm University.
Our main interest is to understand principles of RNA-mediated gene regulation and its contribution to pathologies. Our research tools include structural biology and biophysics, RNA and protein biochemistry as well as various aspects of cell biology. In addition, we run the X-ray crystallography platform at HMGU. Furthermore, we are also closely interacting with our partner lab at the Ulm University.
Public Science
Einführung für Laien in die Thematik Gene, Proteine, Strukturen und PURA-Syndrom (28 Minuten, Deutsch)
Kurze Einführung für Familien mit PURA-Syndrom-Patienten und deren Bekannte.
- We are excited to have contributed to the first virtual PURA Syndrome conference (June 5.-12. 2021).
Watch personal stories, science, and discussions online at the website puraconference.org
At this meeting, families with PURA Syndrome patients gathered and shared ideas, hope, and information. PURA Syndrome is a mono-genetic neurodevelopmental disorder. Although to date, only few hundreds of patients have been identified so far, there is a very active community.
Watch our lab presenting
an overview of the current research team (“Overview and Introduction to the Global Research Network” by Dierk Niessing)
the basics of genes, proteins, the content of cells and what stem cells are (“Genetics 101" by Sandra Burczyk, Lena Molitor, and Sabrina Bacher)
a talk about the function of PURA and how stem cells help us to understand its cellular function ("Stem cells and beyond - what we know about PURAs function in the cell” by Sabrina Bacher and Lena Molitor)
- Recorded Presentation: "What happens if your child is diagnosed with a rare disease?" (English - September 2020; 30 minutes)
This presentation has been recorded in September 2020 as part of the Pint of Science festival Munich.
For further reading on the experience having a child with a rare disease, we recommend the following article:
https://onlinelibrary.wiley.com/doi/full/10.1002/hast.1155
- Radio interview with Dierk Niessing (German - July 2019; 50 minutes)
Radiointerview mit Dierk Niessing durch Frank Riethdorf vom Radio free FM. Es geht um generelle Konzepte der Forschung und der Lehre an der Uni Ulm und dem Helmholtz Zentrum München.
Dierk Niessing was interviewed by Frank Riethdorf from Radio free FM, a non-profit radio station based in Ulm. They discussed the general concept of structural biology as well as his research projects at the Ulm University and his partner lab at the Helmholtz Zentrum München.
- Recorded Presentation: "Overview of PURA-Research Activities" (English - June 2019; 26 minutes)
Presentation by Dierk Niessing at the PURA Syndrome Conference in Boston, USA (June 2019). He gives an overview of current research activities within the so-called Global Research Network that is associated with the PURA Syndrome Foundation.
- “Solving the genome puzzle” - article in The Guardian (English - 2018)
Article by Linda Geddes on rare diseases and PURA Syndrome in the British newspaper The Guardian. The article includes interview sections with affected families and researchers.
- Recorded Presentation: "The potential of induced pluripotent stem cells (iPSCs) for a better understanding of PURA Syndrome" (English - June 2018; 23 minutes)
Presentation by Lena Molitor (Niessing lab Munich) at the PURA Syndrome Conference (The Wellcome Genome Campus Conference Centre, Hinxton, UK) in June 2019. She gives an overview of current state-of-the-art of iPSC-based reseaerch and genome editing methods to better understand the PURA Syndrome.
- Recorded Presentation "PURA: from gene to function" (English - June 2018; 33 minutes)
Presentation by Dierk Niessing at the PURA Syndrome Conference (The Wellcome Genome Campus Conference Centre, Hinxton, UK) in June 2019. He explains what genes and proteins are and how mutations affect genes and proteins, resulting in genetic diseases.
Group members
