Protzer Lab
Our scientific interest is to better understand the interaction of hepatitis B (HBV) and C (HCV) virus with their host and to develop new therapeutic strategies to treat chronic viral hepatitis and hepatocellular carcinoma.
About our Research
The main focus of our group is to understand in molecular detail the interaction of HBV with its host and its host cell, the hepatocyte. Hereby, we investigate which cellular pathways are involved in the control of HBV replication, which viral proteins may counteract them and how HBV is activated or inactivated by immune mediators and metabolites. In addition, we use the advanced understanding of HBV molecular biology for developing targeted antiviral strategies. Based on thorough analyses of immune responses, we design novel immunotherapies, test them in the preclinical mouse models we have established and promote preclinical development of the most promising ones.
Deputy Head of the Molecular Targets and Therapeutics Center, Director Virology
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Publications
Publications
Kosinska, A. ; Kächele, M. ; Kerth, H.A. ; Mück-Häusl, M. ; Ates Öz, E. ; Gültan, M. ; Hansen-Palmus, L. ; Sacherl, J. ; Ko, C. ; Festag, J. ; Lehmann, M.H. ; Mogler, C. ; Steiger, K. ; Knolle, P.A. ; Bauer, T. ; Volz, A.K. ; Protzer, U.
MVA-HBVac-A novel vaccine vector that allows pan-genotypic targeting of hepatitis B virus by therapeutic vaccination.Wu, X. ; Quan, D. ; Li, W. ; Wisskirchen, K. ; Wu, W. ; Zhou, Y. ; Liu, Y.P. ; Wan, X. ; Wang, X. ; Zhang, X. ; Yang, L. ; Zheng, M. ; Zhang, K. ; Protzer, U. ; Du, S. ; Qu, X.
Clinical results of an HBV-specific T-cell receptor-T-cell therapy (SCG101) in patients with HBV-related hepatocellular carcinoma treated in an investigator-initiated, interventional trial.Hammer, E. ; Flynn, C. ; Rössler, J. ; Erder, J. ; Napieralski, R. ; Fricke, L. ; Campbell, B. ; Feuerherd, M. ; Esslinger, F. ; von Brunn, A. ; Weber, T. ; King, S. ; Tan, S. ; Brisson, A.R. ; Protzer, U. ; Schricker, G. ; Gärtner, K. ; Ebert, G. ; Moretti, A. ; Klein, F. ; Knoops, K. ; Heeren, R. ; Hammerschmidt, W. ; Zeidler, R. ; Wilhelm, O. ; Knolle, P.A. ; Höchst, B.
Prediction of COVID-19 disease progression by multiparametric analysis of circulating extracellular vesicles with flow cytometry.Appelman, M.D. ; Nguyen, T.A. ; Oswald, A. ; Lucko, A.M. ; Paulusma, C.C. ; Protzer, U. ; van de Graaf, S.F.J.
NTCP ubiquitination enables HBV infection.Özer, S. ; Strobelt, R. ; Kosinska, A. ; Frishman, G. ; Wettengel, J.M. ; Pleninger, L. ; Körber, N. ; Liang, W. ; Ates Öz, E. ; Zuniga, M. ; Bauer, T. ; Ebert, G. ; Protzer, U. ; Vincendeau, M.
HERV-K10 as a mediator of immune modulation in hepatitis infections.Jaeckel, E. ; Friedman, S.L. ; Hudecek, M. ; Protzer, U.
Chimeric antigen receptor (CAR) T-cell therapy: Engineering immune cells to treat liver diseases.Luo, J. ; Molbay, M. ; Chen, Y. ; Horvath, I. ; Kadletz, K. ; Kick, B. ; Zhao, S. ; Al-Maskari, R. ; Singh, I. ; Ali, M. ; Bhatia, H.S. ; Minde, D.-P. ; Negwer, M. ; Höher, L. ; Calandra, G.M. ; Groschup, B. ; Su, J. ; Kimna, C. ; Rong, Z. ; Galensowske, N. ; Todorov, M.I. ; Jeridi, D. ; Ohn, T.-L. ; Roth, S. ; Simats, A. ; Singh, V. ; Khalin, I. ; Pan, C. ; Arus, B.A. ; Bruns, O.T. ; Zeidler, R. ; Liesz, A. ; Protzer, U. ; Plesnila, N. ; Ussar, S. ; Hellal, F. ; Paetzold, J.C. ; Elsner, M. ; Dietz, H. ; Ertürk, A.
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.Chen, W.L. ; Chang, Y.L. ; Lin, S.F. ; Protzer, U. ; Isogawa, M. ; Yang, H.C. ; Huang, L.R.
Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: Unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironment.Chen, F. ; Wettengel, J.M. ; Gegenfurtner, F. ; Moosmüller, J. ; Bunse, T. ; Jeske, S. ; Hagen, P. ; Ni, Y. ; Urban, S. ; Protzer, U.
Identification of NTCP animal orthologs supporting hepatitis B virus binding and infection.Rust, L.N. ; Wettengel, J.M. ; Biswas, S. ; Ryu, J. ; Piekarski, N. ; Yusova, S. ; Lutz, S.S. ; Naldiga, S. ; Hinrichs, B.J. ; Sullivan, M.N. ; Lo, J.O. ; Protzer, U. ; Smedley, J.V. ; Sacha, J.B. ; Hanna, C.B. ; Bimber, B.N. ; Hennebold, J.D. ; Burwitz, B.J.
Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes.Luzius, T. ; Jeske, S. ; Baer, J. ; Goelnitz, U. ; Protzer, U. ; Wettengel, J.M.
A multiplex polymerase chain reaction assay for the detection of herpes simplex virus, cytomegalovirus, and varicella-zoster virus in cerebrospinal Fluid.Ko, C. ; Cheng, C.-C. ; Mistretta, D. ; Ambike, S. ; Sacherl, J. ; Velkov, S. ; Liao, B.-H. ; Bester, R. ; Gültan, M. ; Polezhaeva, O. ; Herrmann, A. ; Jakwerth, C.A. ; Schmidt-Weber, C.B. ; Bugert, J.J. ; Wölfel, R. ; Grass, V. ; Essbauer, S. ; Schnepf, D. ; Keppler, O.T. ; Vondran, F.W.R. ; Pichlmair, A. ; Mogler, C. ; Ebert, G. ; Protzer, U.
SARS-CoV-2 productively infects human hepatocytes and induces cell death.Li, D. ; Ho, V. ; Teng, C.F. ; Tsai, H.W. ; Liu, Y. ; Bae, S. ; Ajoyan, H. ; Wettengel, J.M. ; Protzer, U. ; Gloss, B.S. ; Rockett, R.J. ; Asady, R.A. ; Li, J. ; So, S. ; George, J. ; Douglas, M.W. ; Tu, T.
Novel digital droplet inverse PCR assay shows that natural clearance of Hepatitis B infection is associated with fewer viral integrations.Jeske, S. ; Wettengel, J.M. ; Gegenfurtner, F. ; Fischer, K. ; Moosmüller, J. ; Chakraborty, A. ; Ko, C. ; Burwitz, B.J. ; Schnieke, A. ; Protzer, U.
Identification of amino acids restricting HBV receptor function in porcine NTCP.Schmidt, A. ; Casadei, N. ; Brand, F. ; Demidov, G. ; Vojgani, E. ; Abolhassani, A. ; Aldisi, R. ; Butler-Laporte, G. ; Alawathurage, T.M. ; Augustin, M. ; Bals, R. ; Bellinghausen, C. ; Berger, M.M. ; Bitzer, M. ; Bode, C. ; Boos, J. ; Brenner, T. ; Cornely, O.A. ; Eggermann, T. ; Erber, J. ; Feldt, T. ; Fuchsberger, C. ; Gagneur, J. ; Göpel, S. ; Haack, T. ; Häberle, H. ; Hanses, F. ; Heggemann, J. ; Hehr, U. ; Hellmuth, J.C. ; Herr, C. ; Hinney, A. ; Hoffmann, P. ; Illig, T. ; Jensen, B.O. ; Keitel, V. ; Kim-Hellmuth, S. ; Koehler, P. ; Kurth, I. ; Lanz, A.L. ; Latz, E. ; Lehmann, C. ; Luedde, T. ; Maj, C. ; Mian, M. ; Miller, A. ; Muenchhoff, M. ; Pink, I. ; Protzer, U. ; Rohn, H. ; Rybniker, J. ; Scaggiante, F. ; Schaffeldt, A. ; Scherer, C. ; Schieck, M. ; Schmidt, S.V. ; Schommers, P. ; Spinner, C.D. ; Vehreschild, M.J.G.T. ; Velavan, T.P. ; Volland, S. ; Wilfling, S. ; Winter, C. ; Richards, J.B. ; Heimbach, A. ; Becker, K. ; Ossowski, S. ; Schultze, J.L. ; Nürnberg, P. ; Nöthen, M.M. ; Motameny, S. ; Nothnagel, M. ; Riess, O. ; Schulte, E.C. ; Ludwig, K.U.
Systematic assessment of COVID-19 host genetics using whole genome sequencing data.Rong, Z. ; Mai, H. ; Ebert, G. ; Kapoor, S. ; Puelles, V.G. ; Czogalla, J. ; Hu, S. ; Su, J. ; Prtvar, D. ; Singh, I. ; Schädler, J. ; Delbridge, C. ; Steinke, H. ; Frenzel, H. ; Schmidt, K. ; Braun, C. ; Bruch, G. ; Ruf, V. ; Ali, M. ; Sühs, K.W. ; Nemati, M. ; Hopfner, F. ; Ulukaya, S. ; Jeridi, D. ; Mistretta, D. ; Caliskan, Ö.S. ; Wettengel, J.M. ; Cherif, F. ; Kolabas, Z.I. ; Molbay, M. ; Horvath, I. ; Zhao, S. ; Krahmer, N. ; Yildirim, A.Ö. ; Ussar, S. ; Herms, J. ; Huber, T.B. ; Tahirovic, S. ; Schwarzmaier, S.M. ; Plesnila, N. ; Höglinger, G. ; Ondruschka, B. ; Bechmann, I. ; Protzer, U. ; Elsner, M. ; Bhatia, H.S. ; Hellal, F. ; Ertürk, A.
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.Einhauser, S. ; Asam, C. ; Weps, M. ; Senninger, A. ; Peterhoff, D. ; Bauernfeind, S. ; Asbach, B. ; Carnell, G.W. ; Heeney, J.L. ; Wytopil, M. ; Fuchs, A. ; Messmann, H. ; Prelog, M. ; Liese, J. ; Jeske, S.D. ; Protzer, U. ; Hoelscher, M. ; Geldmacher, C. ; Überla, K. ; Steininger, P. ; Wagner, R.
Longitudinal effects of SARS-CoV-2 breakthrough infection on imprinting of neutralizing antibody responses.Orabi, A. ; Shameli, K. ; Protzer, U. ; Moeini, H.
Adenoviral fiber-knob based vaccination elicits efficient neutralizing antibodies and T cell responses against adenovirus infection.Ringelhan, M. ; Schuehle, S. ; van de Klundert, M. ; Kotsiliti, E. ; Plissonnier, M.L. ; Faure-Dupuy, S. ; Riedl, T. ; Lange, S. ; Wisskirchen, K. ; Thiele, F. ; Cheng, C.-C. ; Yuan, D.T. ; Leone, V. ; Schmidt, R. ; Hünergard, J. ; Geisler, F. ; Unger, K. ; Algül, H. ; Schmid, R.M. ; Rad, R. ; Wedemeyer, H. ; Levrero, M. ; Protzer, U. ; Heikenwälder, M.
HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx.Du, S. ; Wisskirchen, K. ; Zhang, K. ; Protzer, U.
Correspondence on Editorial regarding "Genetically modified, redirected T cells target hepatitis B surface antigen-positive hepatocytes and hepatocellular carcinoma lesions in a clinical setting".Contact