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Optoacoustic Mesoscopy

He lab

Our group drives the development of multispectral optoacoustic tomography that can enable non-invasive anatomical, functional and mocecular imaging of human skin and biolgical tissue.

He lab

Our group drives the development of multispectral optoacoustic tomography that can enable non-invasive anatomical, functional and mocecular imaging of human skin and biolgical tissue.

About Our Research

We develop raster-scan optoacoustic mesoscopy (RSOM) which is the only technique available that can non-invasively provide highly detailed three dimensional images with resolutions in the tens of microns through the whole skin depth by combining optical excitation with ultra-broad bandwidth ultrasound transducers. With its superior capability, we apply RSOM to assess sub-surface skin features and quantify biomarkers for skin-related disease diagnosis and therapeutic assessment. In addition, we also drive RSOM technique to achieve high resolution and deep penetration inside biological tissue.

Our Focus

We build high resolution and high speed optoacoustic mesoscopy imaging technique based on ultra broadbandwith ultrasound transducers to assess skin morphology and function status and develop machine learning based analysis pipeline to quantify various skin features.

We apply optoacoustic mesoscopy to extract skin morphological and functional features for skin-related disease diagnosis and therapeutic assessment. In addition, optoacoustic mesoscopy is an ideal tool to image small tissue sample, organoids, mouse tumor models for various biological applications.

We develop multimodal microscope which combines contrast rich optoacoustic microscopy with nonlinear microscopy for the label-free investigation of cell cultures and small animals. Both techniques are known to provide unique depth-to-resolution ratios but visualize different features of living specimen such as hemoglobin, melanin, lipid bi-layers, collagen and endogenous autofluorescent molecules concurrently. Optoacoustic microscopy and nonlinear microscopy therefore complement each other and provide unseen insights in biology.

Our researchers

Bayan Alkotub

Ph.D. Student

Bjarne Perleberg

Ph.D. Student
Erik Riedel

Erik Riedel

Ph.D. Student

Dr. Shilpa Tayal

Postdoc

Fei Wang

Ph.D. Student

Patrick Wustrow

Clinical Scientist

Optoacoustic Mesoscopy: Contact

Dr. Hailong He

Group Leader

Einsteinstr. 25, TranslaTUM (bldg. 522), room 22.3.42