IBMI Optoacoustic Mesoscopy

He lab

Our group drives the development of multispectral optoacoustic tomography that can enable non-invasive anatomical, functional and mocecular imaging of human skin and biolgical tissue.

Go to Dr. Hailong He

He Lab

Our group drives the development of multispectral optoacoustic tomography that can enable non-invasive anatomical, functional and mocecular imaging of human skin and biolgical tissue.

Go to Dr. Hailong He

We develop raster-scan optoacoustic mesoscopy (RSOM) which is the only technique available that can non-invasively provide highly detailed three dimensional images with resolutions in the tens of microns through the whole skin depth by combining optical excitation with ultra-broad bandwidth ultrasound transducers. With its superior capability, we apply RSOM to assess sub-surface skin features and quantify biomarkers for skin-related disease diagnosis and therapeutic assessment. In addition, we also drive RSOM technique to achieve high resolution and deep penetration inside biological tissue.

We build high resolution and high speed optoacoustic mesoscopy imaging technique based on ultra broadbandwith ultrasound transducers to assess skin morphology and function status and develop machine learning based analysis pipeline to quantify various skin features.

We apply optoacoustic mesoscopy to extract skin morphological and functional features for skin-related disease diagnosis and therapeutic assessment. In addition, optoacoustic mesoscopy is an ideal tool to image small tissue sample, organoids, mouse tumor models for various biological applications.

We develop multimodal microscope which combines contrast rich optoacoustic microscopy with nonlinear microscopy for the label-free investigation of cell cultures and small animals. Both techniques are known to provide unique depth-to-resolution ratios but visualize different features of living specimen such as hemoglobin, melanin, lipid bi-layers, collagen and endogenous autofluorescent molecules concurrently. Optoacoustic microscopy and nonlinear microscopy therefore complement each other and provide unseen insights in biology.

Englert, L. ; Perleberg, B. ; Tayal, S. ; Wang, B. ; Huang, Y. ; Azeem, M. ; He, H. ; Stiel, A.-C. ; Ntziachristos, V.

Assessment of performance characteristics of photoswitchable bacteriophytochromes at different depths using optoacoustic mesoscopy.

Huang, S. ; He, H. ; Tom, R.Z. ; Glasl, S. ; Anzenhofer,P. ; Stiel, A.-C. ; Hofmann, S.M. ; Ntziachristos, V.

Non-invasive optoacoustic imaging of dermal microcirculatory revascularization in diet-induced obese mice undergoing exercise intervention.

Uluc, N. ; Glasl, S. ; Gasparin, F. ; Yuan, T. ; He, H. ; Jüstel, D. ; Pleitez, M.A. ; Ntziachristos, V.

Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals.

He, H. ; Paetzold, J.C. ; Borner, N. ; Riedel, E. ; Gerl, S. ; Schneider, S. ; Fisher, C. ; Ezhov, I. ; Shit, S. ; Li, H. ; Rückert, D. ; Aguirre, J. ; Biedermann, T. ; Darsow, U. ; Menze, B. ; Ntziachristos, V.

Machine learning analysis of human skin by optoacoustic mesoscopy for automated extraction of psoriasis and aging biomarkers.

He, H. ; Fischer, C. ; Darsow, U. ; Aguirre, J. ; Ntziachristos, V.

Quality control in clinical raster-scan optoacoustic mesoscopy.

Karlas, A. ; Katsouli, N. ; Fasoula, N.-A. ; Bariotakis, M. ; Chlis, N.-K. ; Omar, M. ; He, H. ; Iakovakis, D. ; Schäffer, C. ; Kallmayer, M. ; Füchtenbusch, M. ; Ziegler, A.-G. ; Eckstein, H.H. ; Hadjileontiadis, L.J. ; Ntziachristos, V.

Dermal features derived from optoacoustic tomograms via machine learning correlate microangiopathy phenotypes with diabetes stage.

He, H. ; Englert, L. ; Ntziachristos, V.

Optoacoustic endoscopy of the gastrointestinal tract.

He, H. ; Fasoula, N.-A. ; Karlas, A. ; Omar, M. ; Aguirre Bueno, J. ; Lutz, J. ; Kallmayer, M. ; Füchtenbusch, M. ; Eckstein, H.H. ; Ziegler, A.-G. ; Ntziachristos, V.

Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy.

Nau, T. ; Schönmann, C. ; Hindelang, B. ; Riobo, L. ; Doll, A. ; Schneider, S.A. ; Englert, L. ; He, H. ; Biedermann, T. ; Darsow, U. ; Lauffer, F. ; Ntziachristos, V. ; Aguirre Bueno, J.

Raster-scanning optoacoustic mesoscopy biomarkers for atopic dermatitis skin lesions.

He, H. ; Schönmann, C. ; Schwarz, M. ; Hindelang, B. ; Berezhnoi, A. ; Steimle-Grauer, S.A. ; Darsow, U. ; Aguirre Bueno, J. ; Ntziachristos, V.

Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo.

Gerl, S. ; Paetzold, J.C. ; He, H. ; Ezhov, I. ; Shit, S. ; Kofler, F. ; Bayat, A.A. ; Tetteh, G. ; Ntziachristos, V. ; Menze, B.

A distance-based loss for smooth and continuous skin layer segmentation in optoacoustic images.

Hindelang, B. ; Aguirre Bueno, J. ; Berezhnoi, A. ; He, H. ; Eyerich, K. ; Ntziachristos, V. ; Biedermann, T. ; Darsow, U.

Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing.

Schoenmann, C. ; Aguirre Bueno, J. ; He, H. ; Berezhnoi, A. ; Hindelang, B. ; Biedermann, T. ; Darsow, U.

Optoacoustic imaging in patients with livedoid vasculopathy - Case report.

He, H. ; Stylogiannis, A. ; Afshari, P. ; Wiedemann, T. ; Steiger, K. ; Bühler, A. ; Zakian, C. ; Ntziachristos, V.

Capsule optoacoustic endoscopy for esophageal imaging.

He, H.

Optoacoustic endoscopy: System development and application.

He, H. ; Bühler, A. ; Bozhko, D. ; Jian, X. ; Cui, Y. ; Ntziachristos, V.

Importance of ultrawide bandwidth for optoacoustic esophagus imaging.

He, H. ; Prakash, J. ; Bühler, A. ; Ntziachristos, V.

Fast sparse recovery and coherence factor weighting in optoacoustic tomography.

He, H. ; Wissmeyer, G. ; Ovsepian, S.V. ; Bühler, A. ; Ntziachristos, V.

Optoacoustic endoscopy with optical and acoustic resolution.

He, H. ; Prakash, J. ; Bühler, A. ; Ntziachristos, V.

Optoacoustic tomography using accelerated sparse recovery and coherence factor weighting.

He, H. ; Mandal, S. ; Bühler, A. ; Dean-Ben, X.L. ; Razansky, D. ; Ntziachristos, V.

Optoacoustic imaging quality enhancement based on geometrical super-resolution method.

He, H. ; Bühler, A. ; Ntziachristos, V.

Optoacoustic endoscopy in curved scanning mode.

He, H. ; Wissmeyer, G. ; Ovsepian, S.V. ; Bühler, A. ; Ntziachristos, V.

Hybrid optical and acoustic resolution optoacoustic endoscopy.

He, H. ; Mandal, S. ; Bühler, A. ; Dean-Ben, X.L. ; Razansky, D. ; Ntziachristos, V.

Improving optoacoustic image quality via geometric pixel super-resolution approach.

He, H. ; Bühler, A. ; Ntziachristos, V.

Optoacoustic endoscopy with curved scanning.

Yoon, H. ; He, H. ; Nagy, R. ; Davuluri, R. ; Suster, S. ; Schoenberg, D. ; Pellegata, N.S. ; de la Chapelle, A.

Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest.

Optoacoustic Mesoscopy

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Optoacoustic mesoscopy development

Clinical and biological applications

Hybrid microscopy

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