Schneider Lab Publications
2024 Editorial in Epigenomics Epigenomics 16, 1061-1065 (2024)
Breaking the epigenetic code with MARCS: The Modification Atlas of Regulation by Chromatin States.
2024 EMBO Reports EMBO Rep., 3202–3220 (2024)
Publisher Correction: Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 1-16 (Methods Mol. Biol. ; 2846)
Native ChIP: Studying the genome-wide distribution of histone modifications in cells and tissue.
2024 Review in EMBO Reports EMBO Rep. 25, 3202-3220 (2024)
Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Other: Opinion in Nature Reviews - Genetics Nat. Rev. Genet., DOI: 10.1038/s41576-024-00758-2 (2024)
Decoding the language of chromatin modifications with MARCS.
2024 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-024-01341-3 (2024)
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
2024 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 52, 6129-6144 (2024)
asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers.
2024 Nature Nature 628:E6 (2024)
Publisher Correction: Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2960 (2024)
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
2024 Scientific Article in Nature Nature 627, 671-679 (2024)
Decoding chromatin states by proteomic profiling of nucleosome readers.
2023 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-023-01179-1 (2023)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1628-1639 (2023)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Scientific Article in Nature Cell Biology Nat. Cell Biol. 25, 1017-1032 (2023)
Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability.
2023 Scientific Article in Genes and Development Genes Dev. 37, 336-350 (2023)
A change in biophysical properties accompanies heterochromatin formation in mouse embryos.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Editorial in Nucleic Acids Research Nucleic Acids Res. 51, 7709-7713 (2023)
Editorial: Colyn Crane-Robinson (1935-2023).
2023 Scientific Article in Life Science Alliance Life Sci. All. 6:19 (2023)
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler.
2023 Scientific Article in Cell Reports Cell Rep. 42:112045 (2023)
Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
2022 Scientific Article in Cell Reports Cell Rep. 41:111656 (2022)
Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance.
2022 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 18:e1010640 (2022)
Altered expression response upon repeated gene repression in single yeast cells.
2022 Scientific Article in Life Science Alliance Life Sci. All. 5:e202201572 (2022)
The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program.
Methods in Molecular Biology In: Histone Methyltransferases. 2022. 327-403 (Methods Mol. Biol. ; 2529)
Identifying specific protein interactors of nucleosomes carrying methylated histones using quantitative mass spectrometry.
2022 Scientific Article in Molecular Biology of the Cell Mol. Biol. Cell 33:lt1 (2022)
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1.
2022 Scientific Article in Micromachines Micromachines 13:1146 (2022)
Droplet microfluidic device for chemoenzymatic sensing.
2022 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 50, 8491-8511 (2022)
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.
2022 Scientific Article in Nature Communications Nat. Commun. 13:1303 (2022)
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
2022 Review in Nature Reviews - Genetics Nat. Rev. Genet. 23, 563-580 (2022)
Histone post-translational modifications - cause and consequence of genome function.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 2944-2959.e10 (2021)
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin.
2021 Review in EMBO Reports EMBO Rep. 22:e52774 (2021)
Histone acylations and chromatin dynamics: Concepts, challenges, and links to metabolism.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 2793-2807.e8 (2021)
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:8797 (2021)
An asymmetric flow-focusing droplet generator promotes rapid mixing of reagents.
2021 Scientific Article in EMBO Reports EMBO Rep. 22:e51009 (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.
2021 Review in Nucleic Acids Research Nucleic Acids Res. 49, 3020–3032 (2021)
Staying true to yourself: Mechanisms of DNA methylation maintenance in mammals
2020 Scientific Article in STAR Protocols STAR Protoc. 1:100228 (2020)
Microfluidics for single-cell lineage tracking over time to characterize transmission of phenotypes in Saccharomyces cerevisiae.
2020 Scientific Article in Science Advances Sci. Adv. 6:eaaz4551 (2020)
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth.
2020 Review in Current Genetics Curr. Genet. 66, 1029–1035 (2020)
The past determines the future: Sugar source history and transcriptional memory.
2020 Scientific Article in Nature Communications Nat. Commun. 11:3559 (2020)
Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis.
2020 Scientific Article in Nature Communications Nat. Commun. 11:2952 (2020)
Cell size sets the diameter of the budding yeast contractile ring.
2020 Scientific Article in Molecular Cell Mol. Cell 78, 915-925 (2020)
Single-cell tracing dissects regulation of maintenance and inheritance of transcriptional reinduction memory.
2020 Review in Molecular Metabolism Mol. Metab. 38:100987 (2020)
You are what you eat-How nutrition and metabolism shape the genome through epigenetics.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A7-A7 (2020)
Fate trajectory modeling reveals convergence of airway derived progenitors and AT2 cells on transient KRT8+alveolar cell state during lung regeneration.
2020 Scientific Article in Genes and Development Genes Dev. 34, 715-729 (2020)
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
2019 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-019-0341-8 (2019)
Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes (Nature Structural & Molecular Biology, (2019), 26, 10, (899-909), 10.1038/s41594-019-0293-z).
2019 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 26, 899-909 (2019)
G-tract RNA removes Polycomb repressive complex 2 from genes.
2019Poster: CSH meeting: mechanisms of metabolic signaling, 14 May 2019, Cold Spring Harbour, NY, USA. (2019)
Glucose starvation in Huh7 cells triggers a transcriptional memory.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:6584 (2019)
The interactome of a family of potential methyltransferases in HeLa cells.
2019 Other: Opinion in Molecular & Cellular Oncology Mol. Cell. Oncol. 6:1605820 (2019)
A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.
2019 Scientific Article in Nature Cell Biology Nat. Cell Biol. 21, 311-318 (2019)
H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
2019 Editorial in Epigenomics Epigenomics 11, 363-366 (2019)
Histone H1, the forgotten histone.
2018 Scientific Article in Molecular Cell Mol. Cell 72, 739-752 (2018)
Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin.
2018Poster: 40 years Myc, 50 years Polymerase II, and 65 years Dirk Eick!, 9 November 2018, Planegg-Martinsried. (2018)
Regulation of transcription: RNA Pol II and Myc.
2018 Scientific Article in Nature Communications Nat. Commun. 9:1653 (2018)
Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry.
2018 Scientific Article in BMC Evolutionary Biology BMC Evol. Biol. 18:96 (2018)
Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.
2018 Review in Molecular Metabolism Mol. Metab., DOI: 10.1016/j.molmet.2018.01.007 (2018)
Metabolic intermediates - Cellular messengers talking to chromatin modifiers.
2017 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 1048–1056 (2017)
Histone propionylation is a mark of active chromatin.
2017 Scientific Article in Journal of Cell Biology, The J. Cell Biol. 216, 3017-3028 (2017)
Dynamic changes in H1 subtype composition during epigenetic reprogramming.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006959 (2017)
Loss of the chromatin modifier Kdm2aa causes BrafV-600E -independent spontaneous melanoma in zebrafish.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:5418 (2017)
Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.
2017 Scientific Article in OncoTarget Oncotarget 8, 38239-38250 (2017)
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 681-686 (2016)
Histone H3 globular domain acetylation identifies a new class of enhancers.
2016 Review in Trends in Genetics Trends Genet. 32, 42-56 (2016)
Lateral thinking: How histone modifications regulate gene expression.
2016 Scientific Article in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1859, 486-495 (2016)
The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10782 (2016)
Hypothalamic leptin action is mediated by histone deacetylase 5.
2016 Scientific Article in Genome Biology Genome Biol. 17:8 (2016)
H1 gets the genome in shape.
2016 Editorial in Cell Cell 164, 341-342 (2016)
Epigenetic ON/OFF switches for obesity.
2015 Scientific Article in EMBO Reports EMBO Rep. 16, 1439-1453 (2015)
The H1 linker histones: Multifunctional proteins beyond the nucleosomal core particle.
2015 Scientific Article in Scientific Reports Sci. Rep. 5:14756 (2015)
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.
2015 Scientific Article in FEBS Journal, The FEBS J. 282, 1658-1674 (2015)
Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest.
2015 Scientific Article in Epigenetics Epigenetics, DOI: 10.1080/15592294.2015.1103424 (2015)
Dynamics of histone H3 acetylation in the nucleosome core during mouse pre-implantation development.
2015 Scientific Article in Virchows Archiv Virchows Arch. 466, 503-515 (2015)
Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas.
2014 Scientific Article in eLife eLife 3:e01632 (2014)
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.
2014 Scientific Article in Scientific Reports Sci. Rep. 4:6674 (2014)
Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis.
2014 Scientific Article in Trends in Cell Biology Trends Cell Biol. 24, 712-723 (2014)
Epigenetics reloaded: The single-cell revolution.
2014 Scientific Article in Cell and Tissue Research Cell Tissue Res. 356, 457-466 (2014)
Histone variants: Key players of chromatin.
2013 Scientific Article in Cell Cell 152, 859-872 (2013)
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
2013 Scientific Article in Cell Reports Cell Rep. 3, 2142-2154 (2013)
The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells.
2013 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 20, 657-661 (2013)
Scratching the (lateral) surface of chromatin regulation by histone modifications.
2013 Scientific Article in Briefings in Functional Genomics Brief. Funct. Genomic. Proteomic. 12, 231-243 (2013)
Cancers with wrong HATs: The impact of acetylation.
2013 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 110, E2191-E2198 (2013)
Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.
2013 Scientific Article in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 25, 184-189 (2013)
Targeting histone modifications - epigenetics in cancer.
2013 Scientific Article in Nature Communications Nat. Commun. 4:2233 (2013)
Dissecting the role of H3K64me3 in mouse pericentromeric heterochromatin.
2012 Scientific Article in Genes and Development Genes Dev. 26, 797-802 (2012)
A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.
2012 Scientific Article in Journal of Molecular Biology J. Mol. Biol. 419, 183-197 (2012)
Linker histone subtypes differ in their effect on nucleosomal spacing in vivo.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 1104-1110 (2012)
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
2012 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 5:7 (2012)
A unified phylogeny-based nomenclature for histone variants.
2011 Scientific Article in Journal of Cell Science J. Cell Sci. 124, 1623-1628 (2011)
Isoform-specific phosphorylation of human linker histone H1.4 in mitosis by the kinase Aurora B.
2011 Scientific Article in Genes and Development Genes Dev. 25, 673-678 (2011)
The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.
2011 Scientific Article in Genes and Cancer Genes Cancer 2, 631-647 (2011)
Histone modifiers in cancer: Friends or foes?
2011 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 4:11 (2011)
Methylation of H2AR29 is a novel repressive PRMT6 target.
2010 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 3:7 (2010)
Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.
2010 Scientific Article in Journal of Experimental Medicine J. Exp. Med. 207, 711-719 (2010)
Arginine methylation of the B cell antigen receptor promotes differentiation.
2010 Scientific Article in BioEssays Bioessays 32, 659-668 (2010)
What an epigenome remembers.
2010 Scientific Article in Briefings in Functional Genomics Brief. Funct. Genomic. Proteomic. 9, 429-443 (2010)
Chatting histone modifications in mammals.
2010 Scientific Article in Molecular BioSystems Mol. Biosyst. 6, 1719-1729 (2010)
Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001234 (2010)
Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding.
2010 Scientific Article in Epigenetics Epigenetics 5, 112-117 (2010)
Going global: novel histone modifications in the globular domain of H3.
2009 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 16, 777-781 (2009)
H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming.
2009 Scientific Article in Chemistry and Biology Chem. Biol. 16, 1027-1029 (2009)
Tools to tackle protein acetylation.
2008 Scientific Article in Nature Nature 452, 877-881 (2008)
Chromatin dynamics during epigenetic reprogramming in the mouse germ line.
2008 Scientific Article in Biological Chemistry Biol. Chem. 389, 333-343 (2008)
The histone H1 family: Specific members, specific functions?
2008 Scientific Article in Development / Company of Biologists Development 135, 1935-1946 (2008)
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity.
2008 Scientific Article in Molecular and Cellular Biology Mol. Cell. Biol. 28, 4688-4696 (2008)
Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.
2007 Scientific Article in Nature Cell Biology Nat. Cell Biol. 9, 347-353 (2007)
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
2007 Review in Genes and Development Genes Dev. 21, 3027-3043 (2007)
Dynamics and interplay of nuclear architecture, genome organization, and gene expression.
2006 Scientific Article in Nature Cell Biology Nat. Cell Biol. 8, 623-630 (2006)
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.
2005 Scientific Article in Nature Nature 437, 436-439 (2005)
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.
2005 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 280, 38090-38095 (2005)
HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.
2005 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 280, 17732-17736 (2005)
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes.
2004 Scientific Article in Nature Cell Biology Nat. Cell Biol. 6, 73-77 (2004)
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes.
2004 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 279, 23859-23862 (2004)
Direct binding of INHAT to H3 tails disrupted by modifications.
2004 Scientific Article in Cell Cell 118, 545-553 (2004)
Histone deimination antagonizes arginine methylation.
2003 Scientific Article in Development / Company of Biologists Development 130, 4235-4248 (2003)
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development.
2003 Scientific Article in Molecular Cell Mol. Cell 12, 1325-1332 (2003)
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.
2003 Scientific Article in Journal of Molecular Biology J. Mol. Biol. 331, 331-344 (2003)
Mechanism of transcriptional activation by FIS: role of core promoter structure and DNA topology.
2002 Scientific Article in Methods Methods 26, 226-232 (2002)
Protein N-methyltransferase assays in the study of gene transcription.
2002 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 99, 8695-8700 (2002)
Methylation of histone H3 Lys 4 in coding regions of active genes.
2002 Scientific Article in Trends in Biochemical Sciences : TIBS Trends Biochem. Sci. 27, 396-402 (2002)
Unsafe SETs: Histone lysine methyltransferases and cancer.
2002 Review in Cell Cell 109, 801-806 (2002)
Histone methylation: Dynamic or static?
2002 Scientific Article in Nature Nature 419, 407-411 (2002)
Active genes are tri-methylated at K4 of histone H3.
2001 Scientific Article in Nature Nature 412, 561-565 (2001)
Rb targets histone H3 methylation and HP1 to promoters.
2001 Scientific Article in Biochimie Biochimie 83, 213-217 (2001)
DNA supercoiling and transcription in Escherichia coli: The FIS connection.
2001 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 29, 5107-5114 (2001)
An architectural role of the Escherichia coli chromatin protein FIS in organising DNA.
2001 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 276, 17878-17886 (2001)
CRP modulates fis transcription by alternate formation of activating and repressing nucleoprotein complexes.
2000 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 275, 8103-8113 (2000)
Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli.
2000 Scientific Article in Molecular Microbiology Mol. Microbiol. 38, 167-175 (2000)
The expression of the Escherichia coli fis gene is strongly dependent on the superhelical density of DNA.
1999 Scientific Article in Molecular Microbiology Mol. Microbiol. 34, 953-964 (1999)
A DNA architectural protein couples cellular physiology and DNA topology in Escherichia coli.
1997 Scientific Article in Molecular Microbiology Mol. Microbiol. 26, 519-530 (1997)