Lung Cell Atlas

Helmholtz Munich and Parse Biosciences Collaborate on Human Lung Tissue Perturbation Atlas

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Helmholtz Munich and Parse Biosciences have entered into a collaboration to generate one of the most comprehensive lung disease perturbation atlases to date. The project uses a human lung ex vivo tissue slice culture model derived from both healthy donor lungs and explanted lung tissue from patients with chronic lung disease. By applying Parse Biosciences’ GigaLab single-cell sequencing platform, researchers will investigate cellular responses to 900 pharmacological interventions. The resulting atlas is expected to provide new insights into disease mechanisms and support the identification of potential therapeutic targets and cell circuits relevant to lung health and disease.

Prof. Herbert Schiller, Director of Helmholtz Munich’s Precision Regenerative Medicine Research Unit, and a leading researcher on lung biology and disease, will head this ambitious initiative. “Measuring the effects of drug treatments at single cell level directly in human lung tissue at scale will help us to find strategies that improve lung tissue regeneration, which may lead to the targeted combination therapies of the future,” states Schiller. 

Prof. Fabian Theis, who heads Helmholtz Munich’s Computational Health Center, adds, “To build foundational AI models of cell and tissue biology, we are in urgent need for more high-quality perturbation data  such a complex drug perturbation dataset will enable meaningful progress towards understanding gene regulation in lung health and disease.” 

This initiative will be run through the Parse GigaLab, a state-of-the-art facility purpose-built for the generation of massive-scale single cell RNA sequencing datasets. Leveraging Parses Evercode chemistry, the GigaLab rapidly produces large single cell datasets with exceptional quality.

“With GigaLab, we’re enabling researchers to move past incremental discoveries,” states Charlie Roco, PhD, Co-founder and Chief Technology Officer at Parse Biosciences. “Our collaboration with Helmholtz Munich demonstrates how vision and scale in single cell genomics can uncover biology, accelerating the path to better therapies.  ‍‍

Fabian Theis
Prof. Dr. Dr. Fabian Theis

Director of Computational Health Center, Director of Institute for Computational Biology

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Schiller_Herbert_Transparent_EHC
Prof. Dr. Herbert Schiller

Director Research Unit Precision Regenerative Medicine

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