Publications
2024 Scientific Article in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02496-z (2024)
Probe set selection for targeted spatial transcriptomics.
2024 Scientific Article in Nature Nature 627, 347-357 (2024)
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
2024 Scientific Article in Nature Communications Nat. Commun. 15:10061 (2024)
Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.
2024 Scientific Article in Nature Nature 635, 690-698 (2024)
An integrated transcriptomic cell atlas of human neural organoids.
2024 Scientific Article in Journal of Visualized Experiments J. Vis. Exp., DOI: 10.3791/66659:211 (2024)
Application of unsupervised multi-omic factor analysis to uncover patterns of variation and molecular processes linked to cardiovascular disease.
2024 Scientific Article in Cell Research Cell Res., DOI: 10.1038/s41422-024-01045-9 (2024)
A cross-species foundation model for single cells.
2024 Scientific Article in Genome Biology Genome Biol. 25:277 (2024)
Mapping lineage-traced cells across time points with moslin.
2024 Scientific Article in Diabetes, Obesity and Metabolism Diabetes Obes. Metab., DOI: 10.1111/dom.16022 (2024)
Subphenotypes of adult-onset diabetes: Data-driven clustering in the population-based KORA cohort.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:149 (2024)
Association analysis between an epigenetic alcohol risk score and blood pressure.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00227-w (2024)
Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients.
2024 Scientific Article in Cells Cells 13:408 (2024)
Comparing viral vectors and fate mapping approaches for astrocyte-to-neuron reprogramming in the injured mouse cerebral cortex.
2024 Scientific Article in Nature medicine Nat. Med., DOI: 10.1038/s41591-024-03214-0 (2024)
An open-source framework for end-to-end analysis of electronic health record data.
2024 Editorial in Epigenomics Epigenomics 16, 1061-1065 (2024)
Breaking the epigenetic code with MARCS: The Modification Atlas of Regulation by Chromatin States.
2024 EMBO Reports EMBO Rep., 3202–3220 (2024)
Publisher Correction: Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadl4374 (2024)
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Scientific Article in BMC Medicine BMC Med. 22:420 (2024)
Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies.
2024 Review in Nature Methods Nat. Methods 21, 1597-1602 (2024)
Small data methods in omics: The power of one.
2024 Scientific Article in Frontiers in bioengineering and biotechnology Front. Bioeng. Biotechnol. 12:1422235 (2024)
A multiparametric analysis including single-cell and subcellular feature assessment reveals differential behavior of spheroid cultures on distinct ultra-low attachment plate types.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 1-16 (Methods Mol. Biol. ; 2846)
Native ChIP: Studying the genome-wide distribution of histone modifications in cells and tissue.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 63-89 (Methods Mol. Biol. ; 2846)
Differential analysis of protein-DNA binding using ChIP-seq data.
2024 Scientific Article in Nature Communications Nat. Commun. 15:6611 (2024)
scTab: Scaling cross-tissue single-cell annotation models.
2024 Scientific Article in Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-024-01512-w (2024)
Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis.
2024 Scientific Article in Nature Communications Nat. Commun. 15:7611 (2024)
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
2024 Review in Nature Methods Nat. Methods 21, 1430-1443 (2024)
Transformers in single-cell omics: A review and new perspectives.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00183-5 (2024)
Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level.
2024 Review in EMBO Reports EMBO Rep. 25, 3202-3220 (2024)
Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Scientific Article in Lancet, The Lancet 403, 1027-1050 (2024)
Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
2024 Scientific Article in Kidney international reports Kidney Int. Rep. 9, 1849-1859 (2024)
Prioritization of kidney cell types highlights myofibroblast cells in regulating human blood pressure.
2024 Editorial in Developmental Cell Dev. Cell 59, 1623-1627 (2024)
Understanding how cells and organisms keep time during development.
2024 Scientific Article in Eye Eye, DOI: 10.1038/s41433-024-03264-1 (2024)
Evaluation of OCT biomarker changes in treatment-naive neovascular AMD using a deep semantic segmentation algorithm.
2024 Scientific Article in Nature Computational Science Nat. Comput. Sci. 4, 367–378 (2024)
MISATO: Machine learning dataset of protein-ligand complexes for structure-based drug discovery.
2024 Scientific Article in Cell Cell 187, 4637-4655.e26 (2024)
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
2024 Nature Communications Nat. Commun. 15:6190 (2024)
Author Correction: IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2024 Scientific Article in Genes Genes 15:806 (2024)
Leveraging integrated RNA sequencing to decipher adrenomedullin's protective mechanisms in experimental bronchopulmonary dysplasia.
2024 Scientific Article in Bioinformatics Bioinformatics 40, i548-i557 (2024)
GraphCompass: Spatial metrics for differential analyses of cell organization across conditions.
2024 Nature Genetics Nat. Genet. 56, 1763-1764 (2024)
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Scientific Article in Nature Nature 631, 645-653 (2024)
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
2024 Scientific Article in Genome Biology Genome Biol. 25:181 (2024)
Panpipes: A pipeline for multiomic single-cell and spatial transcriptomic data analysis.
2024 Scientific Article in Nature Neuroscience Nat. Neurosci. 27, 1260–1273 (2024)
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 1397–1411 (2024)
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Scientific Article in Nature Communications Nat. Commun. 15:5577 (2024)
Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data.
2024 Scientific Article in Genome Biology Genome Biol. 25:109 (2024)
hadge: A comprehensive pipeline for donor deconvolution in single-cell studies.
2024 Scientific Article in Diabetes/Metabolism Research and Reviews Diabetes Metab. Res. Rev. 40:e3834 (2024)
Association of transketolase polymorphisms with diabetic polyneuropathy in the general population: The KORA F4 study.
2024 Scientific Article in Metabolites Metabolites 14:258 (2024)
Prediction of myocardial infarction using a combined generative adversarial network model and feature-enhanced loss function.
2024 Scientific Article in Biomolecules Biomolecules 14:662 (2024)
Smoking-induced DNA hydroxymethylation signature is less pronounced than true DNA methylation: The population-based KORA Fit cohort
In: (Proceedings of Machine Learning Research). 2024. 3664-3672 ( ; 238)
Mixed models with multiple instance learning.
2024 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-024-01341-3 (2024)
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
2024 Review in Redox Biology Redox Biol. 75:103211 (2024)
Ferroptosis in health and disease.
2024 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 17:e004374 (2024)
Single-cell dissection of the immune response after acute myocardial infarction.
2024 Review in Physiological Reviews Physiol. Rev. 104, 1679-1717 (2024)
Eukaryotic cell size regulation and its implications for cellular function and dysfunction.
2024 Scientific Article in Developmental Cell Dev. Cell 59, 2347-2363.e9 (2024)
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.
2024 Scientific Article in Nature Cell Biology Nat. Cell Biol. 26, 962-974 (2024)
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 1090-1099 (2024)
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Review in Genome Medicine Genome Med. 16:80 (2024)
Machine learning integrative approaches to advance computational immunology.
2024 Scientific Article in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02303-9 (2024)
CellRank 2: Unified fate mapping in multiview single-cell data.
2024 Scientific Article in Genome Medicine Genome Med. 16:70 (2024)
Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes.
2024 Scientific Article in Nature medicine Nat. Med. 30, 1696-1710 (2024)
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:181 (2024)
Plasma proteome association with coronary heart disease and carotid intima media thickness: Results from the KORA F4 study.
2024 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 52, 6129-6144 (2024)
asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 778-791 (2024)
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
2024 Review in Cell Cell 187, 2343-2358 (2024)
The future of rapid and automated single-cell data analysis using reference mapping.
2024 Scientific Article in Bioinformatics Bioinformatics 40:btae267 (2024)
Topological benchmarking of algorithms to infer Gene Regulatory Networks from Single-Cell RNA-seq Data.
2024 Scientific Article in Journal of Cell Biology, The J. Cell Biol. 223:e202309027 (2024)
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
2024 Nature Genetics Nat. Genet. 56, 1032-1033 (2024)
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2024 Nature Nature 628:E6 (2024)
Publisher Correction: Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Editorial in Cellular Reprogramming Cell. Reprogramm. 26, 37-42 (2024)
Reprogramming Stars #15: Colliding Cellular Reprogramming Paths- An Interview with Dr. Stefan Stricker.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2960 (2024)
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
2024 Scientific Article in Journal of Hepatology J. Hepatol. 81, 289-302 (2024)
Polyploidisation pleiotropically buffers ageing in hepatocytes.
2024 Review in EMBO Reports EMBO Rep. 25, 1721-1733 (2024)
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadn9998 (2024)
Multiple parallel cell lineages in the developing mammalian cerebral cortex.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2866 (2024)
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.
2024 Scientific Article in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02212-x (2024)
SpatialData: An open and universal data framework for spatial omics.
2024 Review in Genes and Development Genes Dev. 38, 98-114 (2024)
Pan-cellular organelles and suborganelles-from common functions to cellular diversity?
2024 Scientific Article in Bioinformatics Bioinformatics 40:btae137 (2024)
Longmixr: A tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types.
2024 Scientific Article in Nature Nature 627, 671-679 (2024)
Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 85:102173 (2024)
The influencers' era: How the environment shapes chromatin in 3D.
2024 Scientific Article in Neuron Neuron 112, 1117-1132.e9 (2024)
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.
2024 Scientific Article in EBioMedicine EBioMedicine 101:105007 (2024)
Phenotypic and genome-wide studies on dicarbonyls: Major associations to glomerular filtration rate and gamma-glutamyltransferase activity.
2024 Scientific Article in Nature Nature 628, 130-138 (2024)
Genome-wide characterization of circulating metabolic biomarkers.
2024 Scientific Article in Biology of Sex Differences Biol. Sex Differ. 15:26 (2024)
Sex and statin-related genetic associations at the PCSK9 gene locus: Results of genome-wide association meta-analysis.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:29 (2024)
Epigenome-wide association study of dietary fatty acid intake.
2024 Scientific Article in Liver International Liver Int. 44, 838-847 (2024)
Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.
2024 Scientific Article in Thorax Thorax 79, 524-537 (2024)
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.
2024 Scientific Article in Nature Communications Nat. Commun. 15:888 (2024)
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
2024 Scientific Article in Journal of Neuroinflammation J. Neuroinflamm. 21:33 (2024)
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.
2024 Editorial in Molecular Cell Mol. Cell 84, 186-188 (2024)
A quick restart: RNA polymerase jumping onto post-replicative chromatin.
2024 Scientific Article in Respiratory Research Respir. Res. 25:49 (2024)
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.
2024 Scientific Article in European Respiratory Journal Eur. Respir. J. 63:2301326 (2024)
Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
2024 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 300:105648 (2024)
Ribosome inactivation regulates translation elongation in neurons.
2024 Scientific Article in Cell Cell 187, 149-165.e23 (2024)
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
2024 Scientific Article in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2024 Scientific Article in Nature Methods Nat. Methods 21, 28–31 (2024)
Modeling fragment counts improves single-cell ATAC-seq analysis.
2024 Scientific Article in Nature Methods Nat. Methods 21, 50-59 (2024)
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells.
2023 Letter to the Editor in Chest Chest 164, 85-89 (2023)
Longitudinal effects of 1-year smoking cessation on human bronchial epithelial transcriptome.
2023 Editorial in Cell Systems Cell Syst. 14, 423-427 (2023)
What do you most hope spatial molecular profiling will help us understand? Part 1.
2023Poster: NeurIPS 2023 AI for Science Workshop (2023)
SpatialSSL: Whole-Brain Spatial Transcriptomics in the Mouse Brain with Self-Supervised Learning.
2023 Meeting abstract in Neuroscience Applied Neurosci. App. 2:101038 (2023)
Effects of glucocorticoid exposure on gene expression and cell fate specification in cerebral organoids.
2023 Scientific Article in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Scientific Article in Atherosclerosis Atherosclerosis 386:117384 (2023)
Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.
2023 Scientific Article in Gastroenterology Gastroenterology 165, 946-962.e13 (2023)
HLA-DP on epithelial cells enables tissue damage by NKp44+ natural killer cells in ulcerative colitis.
2023 Scientific Article in Stroke Stroke 54, 810-818 (2023)
Genetic risk Score for intracranial aneurysms: Prediction of subarachnoid hemorrhage and role in clinical heterogeneity.
2023 Scientific Article in The Lancet Public Health Lancet Public Health 8, e453-e462 (2023)
Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.
2023 Scientific Article in Thorax Thorax 78, 496-503 (2023)
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.
2023 Scientific Article in Gut (eGut) Gut 72, 2068-2080 (2023)
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
2023 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-023-01179-1 (2023)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Letter to the Editor in Nature medicine Nat. Med. 29, 3018-3019 (2023)
Injury-specific signals elicit plasticity in glial cells from patients with brain injury.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:OA2624 (2023)
Spatiotemporal analysis of inflammaging and senescence programs in lung fibrosis using time-resolved single-cell transcriptomics and multiplexed immunofluorescence.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:2 (2023)
Evolution of epithelial-mesenchymal cell circuits in the progression of pulmonary fibrosis.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:3 (2023)
A spatially resolved extracellular matrix proteome atlas of the distal human lung.
2023 Scientific Article in Nature Nature 625, 401–409 (2023)
Emergence of replication timing during early mammalian development.
2023 Scientific Article in Nature human behaviour Nat. Hum. Behav. 7, 790-801 (2023)
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
2023 Meeting abstract in Leukemia Research Leuk. Res. 128:2 (2023)
Multiomic analysis of chip bone marrow hematopoietic stem/progenitor cells reveals potential early stage of malignancy.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:4 (2023)
Single cell atlas of the human retina.
2023 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 29, 1097-1098 (2023)
A genetic association study identifying cis protein quantitative trait loci in patients with MS.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:332 (2023)
Predicting OCT-morphological anti-VEGF treatment response in patients with neovascular age-related degeneration using artificial intelligence.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:330 (2023)
New OCT based definition of treatment response to anti-VEGF in treatment naive neovascular AMD patients using an Deep Learning Algorithm.
2023 Scientific Article in Aging Aging 15, 14509-14552 (2023)
Mapping of the gene network that regulates glycan clock of ageing.
2023 Scientific Article in Science Translational Medicine Sci. Transl. Med. 15, 19:eadh0908 (2023)
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.
2023 Scientific Article in Klinische Monatsblätter für Augenheilkunde Klin. Monatsbl. Augenheilkd., DOI: 10.1055/a-2227-3742 (2023)
Deep Learning based retinal layer segmentation in optical coherence tomography scans of patients with inherited retinal diseases.
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Scientific Article in Nature Nature 615, 874-883 (2023)
Diminishing benefits of urban living for children and adolescents’ growth and development.
2023 Scientific Article in Nature medicine Nat. Med. 29, 3149–3161 (2023)
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.
2023 Scientific Article in Science Advances Sci. Adv. 9:eadj3793 (2023)
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7888 (2023)
Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies.
2023 Editorial in Nature machine intelligence Nat. Mach. Intell. 5, 1176-1178 (2023)
Reporting electricity consumption is essential for sustainable AI.
2023 Scientific Article in Nature Cell Biology Nat. Cell Biol. 12, 1873-1883 (2023)
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2023 Scientific Article in BioSpektrum BioSpektrum 29, 378-380 (2023)
Zugängliche KI-Algorithmen für bessere Zellmikroskopie.
2023 Other: Opinion in Molecular Cell Mol. Cell 83, 3946-3947 (2023)
Too big not to fail: Different paths lead to senescence of enlarged cells.
2023 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, 12303-12324 (2023)
Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency.
2023 Scientific Article in Genes and Development Genes Dev. 37, 901-912 (2023)
Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity.
2023 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 2023:16 (2023)
Single-copy gene locus chromatin purification in Saccharomyces cerevisiae.
2023 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Scientific Article in ACS Nano ACS Nano 17, 21056-21072 (2023)
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice.
2023 Scientific Article in Diabetes Diabetes 72, 1870-1880 (2023)
A faecal metabolite signature of impaired fasting glucose: Results from twoindependent population-based cohorts.
2023 Scientific Article in Cardiovascular Research Cardiovasc. Res. 119, 2743-2754 (2023)
Predictive metabolites for incident myocardial infarction: A two-step meta-analysis of individual patient data from six cohorts comprising 7,897 individuals from the the COnsortium of METabolomic Studies.
2023 Scientific Article in Clinical Epigenetics Clin. Epigenet. 15:166 (2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
2023 Scientific Article in Frontiers in Genetics Front. Genet. 14:1235337 (2023)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
2023 Scientific Article in Genome Biology Genome Biol. 24:234 (2023)
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge.
2023 Scientific Article in Hemasphere Hemasphere 7:e958 (2023)
CSF3R T618I collaborates With RUNX1-RUNX1T1 to expand hematopoietic progenitors and sensitizes to GLI inhibition.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7206 (2023)
Speos: An ensemble graph representation learning framework to predict core gene candidates for complex diseases.
2023 Review in Genes and Development Genes Dev. 37, 779-780 (2023)
Folding makes an imprint.
2023 Scientific Article in Nature Methods Nat. Methods 20, 1683-1692 (2023)
Population-level integration of single-cell datasets enables multi-scale analysis across samples.
2023 Scientific Article in Nature Communications Nat. Commun. 14:6840 (2023)
Reconstructing disease dynamics for mechanistic insights and clinical benefit.
2023 Scientific Article in iScience iScience 26:108205 (2023)
Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors.
Lecture Notes in Computer Science In: (26th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Vancouver, CANADA, 8-12 October 2023). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2023. 514-524 (Lect. Notes Comput. Sc. ; 14227 LNCS)
B-Cos Aligned Transformers Learn Human-Interpretable Features.
2023 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1628-1639 (2023)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1549-1560 (2023)
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth.
2023 Scientific Article in Nature Methods Nat. Methods 20, 1037-1047 (2023)
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Methods in Cell Biology In:. 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa: Elsevier Academic Press Inc, 2023. 199-219 (Methods Cell Biol. ; 182)
An automated image analysis pipeline to quantify the coordination and overlap of transcription and replication activity in mammalian genomes.
2023 Review in AoB Plants AoB Plants 15:plad032 (2023)
Plant environmental memory: Implications, mechanisms and opportunities for plant scientists and beyond.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Scientific Article in Annals of the American Thoracic Society Ann. Am. Thorac. Soc. 20, 1124-1135 (2023)
Systemic markers of lung function and forced expiratory volume in 1 second decline across diverse cohorts.
2023 Nature Immunology Nat. Immunol. 24:1960 (2023)
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (Nature Immunology, (2023), 24, 9, (1540-1551), 10.1038/s41590-023-01588-w).
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 1448-1461 (2023)
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
2023 Nature Genetics Nat. Genet. 55, 1778-1779 (2023)
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (Nature Genetics, (2023), 55, 3, (410-422), 10.1038/s41588-023-01314-0).
2023 Scientific Article in Nature Communications Nat. Commun. 14:5846 (2023)
epiAneufinder identifies copy number alterations from single-cell ATAC-seq data.
2023 Microbiome Microbiome 11:206 (2023)
Correction: Darier’s disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour (Microbiome, (2023), 11, 1, (162), 10.1186/s40168-023-01587-x).
2023 Scientific Article in Nature Communications Nat. Commun. 14:5391 (2023)
The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer.
2023 Scientific Article in Frontiers in Plant Science Front. Plant Sci. 14:1124899 (2023)
Arabidopsis histone deacetylase HD2A and HD2B regulate seed dormancy by repressing DELAY OF GERMINATION 1.
2023 Scientific Article in Genes Genes 14:27 (2023)
Histone deacetylases HD2A and HD2B undergo feedback regulation by ABA and modulate drought tolerance via mediating ABA-induced transcriptional repression.
2023 Scientific Article in Nature metabolism Nat. Metab. 5, 1615-1637 (2023)
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas.
2023 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 24:13 (2023)
Multi-omics regulatory network inference in the presence of missing data.
2023 Scientific Article in Stem Cell Reports Stem Cell Rep. 18, 1972-1986 (2023)
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment.
2023 Editorial in Molecular Systems Biology Mol. Syst. Biol. 19:e11799 (2023)
Single-cell biology: What does the future hold?
2023 Scientific Article in Life Science Alliance Life Sci. All. 6:19 (2023)
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler.
2023 Scientific Article in Genes and Development Genes Dev. 37, 336-350 (2023)
A change in biophysical properties accompanies heterochromatin formation in mouse embryos.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Editorial in Nucleic Acids Research Nucleic Acids Res. 51, 7709-7713 (2023)
Editorial: Colyn Crane-Robinson (1935-2023).
2023 Scientific Article in Development / Company of Biologists Development 150:12 (2023)
CIARA: A cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data.
2023 Scientific Article in Physical Review E Phys. Rev. E 107:044403 (2023)
Emergent statistical laws in single-cell transcriptomic data.
2023 Editorial in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 24, 691-694 (2023)
Heterochromatin definition and function.
2023 Other: Opinion in Genes and Development Genes Dev. 37, 56-57 (2023)
Totipotency, development, and chromatin.
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Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.
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Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling.
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Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.
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A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.
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Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.
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Epigenetic association analyses and risk prediction of RLS.
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Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.
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Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
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An arrhythmogenic metabolite in atrial fibrillation.
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Darier's disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour.
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L-aminoguanidine induces imbalance of ROS/RNS homeostasis and polyamine catabolism of tomato roots after short-term salt exposure.
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Explainable AI identifies diagnostic cells of genetic AML subtypes.
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Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS.
2023 Review in Nature Biotechnology Nat. Biotechnol. 41, 604-606 (2023)
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Best practices for single-cell analysis across modalities.
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Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.
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Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy.
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Gene expression-based molecular test as diagnostic aid for the differential diagnosis of psoriasis and eczema in formalin-fixed and paraffin-embedded tissue, microbiopsies, and tape strips.
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The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant TH2/TH17 immune response.
2023 Scientific Article in Nature medicine Nat. Med. 29, 1563-1577 (2023)
An integrated cell atlas of the lung in health and disease.
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Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps.
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Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
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Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel.
2023 Scientific Article in Cell Cell 186, 3706-3725.e29 (2023)
Distinct molecular profiles of skull bone marrow in health and neurological disorders.
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Single-cell reference mapping to construct and extend cell-type hierarchies.
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OME-Zarr: A cloud-optimized bioimaging file format with international community support.
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Predicting cellular responses to complex perturbations in high-throughput screens.
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Linker histone H1 modulates defense priming and immunity in plants.
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Metabolic signatures elucidate the effect of body mass index on type 2 diabetes.
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ROP2 GTPase participates in nitric oxide (NO)-induced root shortening in arabidopsis.
2023 Scientific Article in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 21, 1697-1710 (2023)
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression.
2023 Scientific Article in Neuron Neuron 111, 1241-1263.e16 (2023)
Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.
2023 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, 1608-1624 (2023)
Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures.
2023 Scientific Article in International Journal of Obesity Int. J. Obes. 47, 313-324 (2023)
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention.
2023 Scientific Article in Nature Cell Biology Nat. Cell Biol. 25, 337-350 (2023)
Biologically informed deep learning to query gene programs in single-cell atlases.
2023 Scientific Article in Cell Reports Cell Rep. 42:112045 (2023)
Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
2023 Scientific Article in Thyroid Thyroid 33, 301-311 (2023)
Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9.
2023 Scientific Article in Bioinformatics Bioinformatics 39:9 (2023)
DeepSom: A CNN-based approach to somatic variant calling in WGS samples without a matched normal.
2023 Scientific Article in JCI insight JCI insight 8:e155968 (2023)
A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 907–916 (2023)
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.
2023 Scientific Article in Nature Biotechnology Nat. Biotechnol. 41, 140–149 (2023)
A proteome-scale map of the SARS-CoV-2-human contactome.
In: (Advances in Neural Information Processing Systems). 2022. ( ; 35)
Sparsity in Continuous-Depth Neural Networks.
In: (Advances in Neural Information Processing Systems). 2022. ( ; 35)
Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution.
In: (Proceedings of Machine Learning Research). 2022. 162-176 ( ; 176)
Multimodal single cell data integration challenge: Results and lessons learned.
2022 Letter to the Editor in Cell Cell 185, 2623-2625 (2022)
The challenges in finding your home as a multidisciplinary scientist.
2022 Scientific Article in Genome Biology Genome Biol. 23:268 (2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Informatik aktuell In: (Bildverarbeitung für die Medizin). 2022. 159 (Inf. aktuell ; 923)
Abstract: A database and neural network for highly accurate classification of single bone marrow cells.
2022 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 45, 264-265 (2022)
Single-cell MultiOmic analysis of CHIP bone marrow stem and progenitor cells provides evidence of early-stage malignant transformation.
2022 Scientific Article in Cell Reports Cell Rep. 41:111865 (2022)
Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation.
2022 Meeting abstract in Experimental Hematology Exp. Hematol. 111, S150-S150 (2022)
Multiomic analysis of bone marrow hematopoietic stem/progenitor cells revals a potential early stage of malignancy of clonal hematopoiesis of indeterminate potential.
2022 Scientific Article in Cell Reports Cell Rep. 41:111867 (2022)
Met/HGFR triggers detrimental reactive microglia in TBI.
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Single-cell multiomics cross-species comparison of pancreas development.
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Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases.
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T cells modulate the microglial response to brain ischemia.
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Genetic diversity fuels gene discovery for tobacco and alcohol use.
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47XXY and 47XXX in scleroderma and myositis.
2022 Letter to the Editor in Development / Company of Biologists Development 149:dev201404 (2022)
In preprints: Improving and interrogating embryo models.
2022 Scientific Article in Environmental Science & Technology Environ. Sci. Technol. 56, 17815-17824 (2022)
Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.
2022 Scientific Article in Nature Neuroscience Nat. Neurosci. 25, 1608-1625 (2022)
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
2022 Scientific Article in Cell Reports Cell Rep. 41:111656 (2022)
Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance.
2022 Nature Nature 612:E7 (2022)
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.
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The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat.
2022 Scientific Article in Genome Medicine Genome Med. 14:125 (2022)
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022 Scientific Article in Biophysical Journal Biophys. J. 121, 4702-4713 (2022)
Single-molecule experiments reveal the elbow as an essential folding guide in SMC coiled coil arms.
2022 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 18:e1010640 (2022)
Altered expression response upon repeated gene repression in single yeast cells.
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Modeling intercellular communication in tissues using spatial graphs of cells.
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Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.
2022 Scientific Article in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 13432 LNCS, 699-708 (2022)
Noise transfer for unsupervised domain adaptation of retinal OCT images.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 727–731 (2022)
Triggering of myocardial infarction by heat exposure is modified by medication intake.
2022 Scientific Article in Clinical and Translational Allergy Clin. Transl. Allergy 12:e12173 (2022)
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response.
2022 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 1366-1387 (2022)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
2022 Scientific Article in BMC Biology BMC Biol. 20:174 (2022)
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC.
2022 Scientific Article in Diabetes Care Diabetes Care 45, 2892–2899 (2022)
Diabetes and obesity in down syndrome across the lifespan: A retrospective cohort study using U.K. electronic health records.
2022 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 18:e11129 (2022)
Probing cell identity hierarchies by fate titration and collision during direct reprogramming.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:16396 (2022)
Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface.
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EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells.
2022 Scientific Article in Cells Cells 11:3289 (2022)
Dendritic cells or macrophages? The microenvironment of human clear cell renal cell carcinoma imprints a mosaic myeloid subtype associated with patient survival.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 1227-1237 (2022)
Origin and function of activated fibroblast states during zebrafish heart regeneration.
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Heterogeneous development of β-cell populations In diabetes-resistant and -susceptible mice.
2022 Scientific Article in Neurology Neurology 99, E1738-E1754 (2022)
Contribution of common genetic variants to risk of early onset ischemic stroke.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6204 (2022)
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
2022 Scientific Article in Immunity Immunity 55, 2285-2299.e7 (2022)
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease.
2022 Scientific Article in Science Science 377:eabo1984 (2022)
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
2022 Scientific Article in Nature Nature 611, 115-123 (2022)
Stroke genetics informs drug discovery and risk prediction across ancestries.
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A transcriptional cross species map of pancreatic islet cells.
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The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program.
Methods in Molecular Biology In: Histone Methyltransferases. 2022. 327-403 (Methods Mol. Biol. ; 2529)
Identifying specific protein interactors of nucleosomes carrying methylated histones using quantitative mass spectrometry.
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Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.
2022 Scientific Article in Molecular Biology of the Cell Mol. Biol. Cell 33:lt1 (2022)
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1.
2022 Scientific Article in Sleep Sleep 45:zsac098 (2022)
Reassessment of candidate gene studies for idiopathic restless legs syndrome in a large GWAS dataset of European ancestry.
2022 Scientific Article in Respiratory Research Respir. Res. 23:227 (2022)
Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa.
2022 Scientific Article in Nature Communications Nat. Commun. 13:5198 (2022)
Identification of risk loci for primary aldosteronism in genome-wide association studies.
2022 Scientific Article in Nature Communications Nat. Commun. 13:4819 (2022)
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
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Interpretable surface-based detection of focal cortical dysplasias: A Multi-centre Epilepsy Lesion Detection study.
2022 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 50, 8491-8511 (2022)
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.
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Common electrocardiogram measures are not associated with telomere length.
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A family and a genome-wide polygenic risk score are independentlyassociated with stroke in a population-based study.
2022 Scientific Article in Nature Communications Nat. Commun. 13:4540 (2022)
Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis.
2022 Editorial in Frontiers in Plant Science Front. Plant Sci. 13:877438 (2022)
Editorial: Functions of nitric oxide in photosynthetic organisms.
2022 Scientific Article in EMBO Reports EMBO Rep.:e54078 (2022)
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2022 Scientific Article in Pancreatology Pancreatol. 22, 449-456 (2022)
Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.
2022 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 18:e1009552 (2022)
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2022 Scientific Article in Atherosclerosis Atherosclerosis 349, 151-159 (2022)
The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.
2022 Scientific Article in Kidney International Kidney Int. 102, 624-639 (2022)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
2022 Scientific Article in Science Science 376:eabf9088 (2022)
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2022 Scientific Article in Environment International Environ. Int. 166:107366 (2022)
Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
2022 Scientific Article in Neuron Neuron 110, 2283-2298.e9 (2022)
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2022 Scientific Article in Cell Reports Cell Rep. 39:110910 (2022)
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
2022 Scientific Article in Science Advances Sci. Adv. 8:eabg9287 (2022)
Excessive local host-graft connectivity in aging and amyloid-loaded brain.
2022 Scientific Article in Science Advances Sci. Adv. 8:eabg9445 (2022)
Brain injury environment critically influences the connectivity of transplanted neurons.
2022 Review in Trends in Cell Biology Trends Cell Biol. 32, 707-719 (2022)
Centrosome heterogeneity in stem cells regulates cell diversity.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 560-572 (2022)
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2022 Scientific Article in JCI insight JCI insight 7:e157035 (2022)
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2022 Scientific Article in Communications Biology Comm. Biol. 5:580 (2022)
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
2022 Scientific Article in Nature Communications Nat. Commun. 13:3456 (2022)
Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage.
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2022 Review in FEBS Letters FEBS Lett. 596, 2596-2616 (2022)
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Integrative analysis of clinical and epigenetic biomarkers of mortality.
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Epigenetic scores for the circulating proteome as tools for disease prediction.
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Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.
2022 Scientific Reports Sci. Rep. 12:6793 (2022)
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9).
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Validation of the 30-year Framingham Risk Score in a German population-based cohort.
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Bezafibrate reduces elevated hepatic fumarate in insulin-deficient mice.
2022 Scientific Article in New Biotechnology New Biotech. 68, 37-47 (2022)
Impact of the pre-examination phase on multicenter metabolomic studies.
2022 Scientific Article in Cell Reports Cell Rep. 38:110547 (2022)
A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.
2022 Scientific Article in Nature Communications Nat. Commun. 13:1303 (2022)
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Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
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2022 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 29:282 (2022)
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2022 Scientific Article in Advanced science Adv. Sci.:e2104979 (2022)
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Scientific Article in Nature Neuroscience Nat. Neurosci. 25, 154-167 (2022)
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler.
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2022 Review in New Phytologist New Phytol. 234, 1119-1125 (2022)
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2022 Scientific Article in Nature Genetics Nat. Genet. 54, 318–327 (2022)
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2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Review in Nature Reviews - Genetics Nat. Rev. Genet. 23, 563-580 (2022)
Histone post-translational modifications - cause and consequence of genome function.
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2022 Scientific Article in Nature Biotechnology Nat. Biotechnol. 40, 163-166 (2022)
A Python library for probabilistic analysis of single-cell omics data.
2022 Scientific Article in Nature Methods Nat. Methods 19, 171–178 (2022)
Squidpy: A scalable framework for spatial omics analysis.
2022 Nature Communications Nat. Commun. 13:1122 (2022)
Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis (Nature Communications, (2022), 13, 1, (143), 10.1038/s41467-021-27706-6).
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2022 Review in Nature Biotechnology Nat. Biotechnol. 40, 308–318 (2022)
Spatial components of molecular tissue biology.
2022 Review in European Respiratory Journal Eur. Respir. J. 59:2102057 (2022)
The discovAIR project: A roadmap towards the Human Lung Cell Atlas.
2022 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 23:bbab535 (2022)
TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 18–29 (2022)
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
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Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.
2022 Scientific Article in Nature Communications Nat. Commun. 13:441 (2022)
Tissue-specific multi-omics analysis of atrial fibrillation.
2022 Scientific Article in Nature Methods Nat. Methods 19, 159–170 (2022)
CellRank for directed single-cell fate mapping.
2022 Scientific Article in Nature Communications Nat. Commun. 13:457 (2022)
Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development.
2022 Scientific Article in Nature Communications Nat. Commun. 13:143 (2022)
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
2022 Scientific Article in Nature Methods Nat. Methods 19, 41-50 (2022)
Benchmarking atlas-level data integration in single-cell genomics.
2022 Review in Neuron Neuron 110, 366-393 (2022)
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches.
2022 Review in Molecular Metabolism Mol. Metab. 57:101396 (2022)
Toward modeling metabolic state from single-cell transcriptomics
2022 Scientific Article in Cells Cells 11:28 (2022)
Enhancer RNA expression in response to glucocorticoid treatment in murine macrophages.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 3367-3376 (2022)
First mitochondrial genome wide association study with metabolomics.
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Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways.
2022 Scientific Article in Cardiovascular Research Cardiovasc. Res. 118, 1088–1102 (2022)
Cis-epistasis at the LPA locus and risk of cardiovascular diseases.
2022 Scientific Article in International Journal of Nonlinear Science Int. J. Nonlinear Sci. 23, 565–577 (2022)
Parameter inference with analytical propagators for stochastic models of autoregulated gene expression.
2021Vortrag: XV European Meeting on Glial Cells in Health and Disease, 07-10 July 2021, online. (2021)
Unravelling the fate determinants of astrocytic identity and their impact in direct neuronal reprogramming.
2021 Review in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 28:100347 (2021)
Graph representation learning for single cell biology.
2021 Scientific Article in Cell Cell 184, 6243-6261.e27 (2021)
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
2021 Scientific Article in Nature Communications Nat. Commun. 12:7173 (2021)
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
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Meta-analyses identify DNA methylation associated with kidney function and damage.
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Histopathology-based deep-learning predicts atherosclerotic lesions in intravascular imaging.
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TUNAR lncRNA encodes a microprotein that regulates neural differentiation and neurite formation by modulating calcium dynamics.
2021 Scientific Article in Nature Nature 600, 675-679 (2021)
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2021 Scientific Article in BMC Cardiovascular Disorders BMC Cardiovasc. Disord. 21:586 (2021)
Polygenic risk for coronary artery disease in the Scottish and English population.
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Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
2021 Scientific Article in Viruses Viruses 13:2537 (2021)
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2021 Editorial in Nature Cell Biology Nat. Cell Biol. 23, 1221-1223 (2021)
Retrotransposing a promoter for development.
2021 Scientific Article in Cells Cells 10:3443 (2021)
Tgf-β induction of mir-143/145 is associated to exercise response by influencing differentiation and insulin signaling molecules in human skeletal muscle.
2021 Scientific Article in Nature Nature 600, 285-289 (2021)
Single-cell transcriptomic characterization of a gastrulating human embryo.
2021 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:12695 (2021)
Cardioprotective effects of palmitoleic acid (C16:1n7) in a mouse model of catecholamine-induced cardiac damage are mediated by PPAR activation.
2021 Letter to the Editor in Trends in Neurosciences Trends Neurosci. 45, 3-5 (2021)
Evolutionary conservation and cell type specificity of nuclear compartments in the brain.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6876 (2021)
scCODA is a Bayesian model for compositional single-cell data analysis.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6883 (2021)
Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α.
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Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6233 (2021)
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6625 (2021)
scPower accelerates and optimizes the design of multi-sample single cell transcriptomic studies.
2021 Scientific Article in American Journal of Psychiatry, The Am. J. Psychiatry 179, 375-387 (2021)
Cell-type-specific impact of glucocorticoid receptor activation on the developing brain: A cerebral organoid study.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 4861-4875.e7 (2021)
Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size.
2021 Scientific Article in American Journal of Respiratory Cell and Molecular Biology Am. J. Respir. Cell Mol. Biol. 65, 366-377 (2021)
Current smoking alters gene expression and DNA methylation in the nasal epithelium of patients with asthma.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6618 (2021)
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
2021 Review in PLoS Biology PLoS Biol. 19:e3001419 (2021)
A field guide to cultivating computational biology.
Lecture Notes in Computer Science In: (3rd MICCAI Workshop on Domain Adaptation and Representation Transfer, DART 2021, 27 September-01 October 2021, Virtual, Online). 2021. 216-225 (Lect. Notes Comput. Sc. ; 12968 LNCS)
Sickle cell disease severity prediction from percoll gradient images using graph convolutional networks.
Lecture Notes in Computer Science In: (24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021, 27 September-01 October 2021, Virtual, Online). 2021. 257-266 (Lect. Notes Comput. Sc. ; 12908 LNCS)
Structure-preserving multi-domain stain color augmentation using style-transfer with disentangled representations.
2021 Review in Diabetologie, Die Diabetologie 17, 788–798 (2021)
Künstliche Intelligenz und maschinelles Lernen in der Diabetesforschung.
2021 Scientific Article in Brain: A Journal of Neurology Brain, DOI: 10.1093/brain/awab360 (2021)
Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset.
2021 Scientific Article in Journal of Visualized Experiments J. Vis. Exp., DOI: 10.3791/63047 (2021)
Cryo-section dissection of the adult subependymal zone for accurate and deep quantitative proteome analysis.
2021 Review in Genome Biology Genome Biol. 22:301 (2021)
Over 1000 tools reveal trends in the single-cell RNA-seq analysis landscape.
2021 Review in Cell and Tissue Research Cell Tissue Res., DOI: 10.1007/s00441-021-03539-z (2021)
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.
2021 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:10291 (2021)
Risk prediction of cardiovascular events by exploration of molecular data with explainable artificial intelligence.
2021 Scientific Article in Immunity Immunity 54, 2497-2513.e9 (2021)
Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 1717-1730 (2021)
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:19365 (2021)
Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
2021 Scientific Article in Epilepsia Epilepsia 62, 1518-1527 (2021)
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations.
2021 Scientific Article in EMBO Journal, The EMBO J.:e107532 (2021)
Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 54:101330 (2021)
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.
2021 Scientific Article in Frontiers in Public Health Front. Publ. Health 9:583377 (2021)
Group testing for SARS-CoV-2 allows for up to 10-fold efficiency increase across realistic scenarios and testing strategies.
2021 Scientific Article in Lancet, The Lancet 398, 957-980 (2021)
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants.
2021 Review in Plant Physiology and Biochemistry Plant Physiol. Biochem. 167, 851-861 (2021)
Computational prediction of NO-dependent posttranslational modifications in plants: Current status and perspectives.
2021 Scientific Article in Nature Communications Nat. Commun. 12:5228 (2021)
EpiScanpy: Integrated single-cell epigenomic analysis.
2021 Review in Molecular Systems Biology Mol. Syst. Biol. 17:e10282 (2021)
RNA velocity-current challenges and future perspectives.
2021 Scientific Article in Genome Biology Genome Biol. 22:248 (2021)
Sfaira accelerates data and model reuse in single cell genomics.
2021 Scientific Article in Nature metabolism Nat. Metab. 3, 1202-1216 (2021)
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
2021 Scientific Article in Nature Biotechnology Nat. Biotechnol., DOI: 10.1038/s41587-021-01001-7 (2021)
Mapping single-cell data to reference atlases by transfer learning.
2021 Review in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:698002 (2021)
Non-codon optimized PiggyBac transposase induces developmental brain aberrations: A call for in vivo analysis.
2021 Scientific Article in Acta Horticulturae Acta Hortic. 1315, 105-112 (2021)
Transient expression of HDA19 recombinant protein in Nicotiana benthamiana.
2021 Scientific Article in Nature Nature 596, 393-397 (2021)
Genetic insights into biological mechanisms governing human ovarian ageing.
2021 Other: Opinion in Nature Cell Biology Nat. Cell Biol. 23, 814-816 (2021)
Deconfining heterochromatin for expression.
2021 Scientific Article in Journal of Hypertension J. Hypertens. 39, 2527-2533 (2021)
N-glycosylation of immunoglobulin G predicts incident hypertension.
2021 Scientific Article in Nature Communications Nat. Commun. 12:4515 (2021)
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
2021 Editorial in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 70, III-V (2021)
Editorial overview: Fluidity of cell fates - from reprogramming to repair.
2021 Review in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:699771 (2021)
Single-molecule techniques to study chromatin.
2021 Scientific Article in Cell Reports Cell Rep. 36:109409 (2021)
Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
2021 Scientific Article in Blood Blood 138, 1917-1927 (2021)
Highly accurate differentiation of bone marrow cell morphologies using deep neuralnetworks on a large image dataset
2021 Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-021-00735-5 (2021)
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation.
2021 Scientific Article in Antioxidants Antioxidants 10:1128 (2021)
Gsnor contributes to demethylation and expression of transposable elements and stress-responsive genes.
2021 Scientific Article in Cell Systems Cell Syst. 12, 706-715.e4 (2021)
AutoGeneS: Automatic gene selection using multi-objective optimization for RNA-seq deconvolution.
2021 Scientific Article in Nature Communications Nat. Commun. 12:4202 (2021)
Transcription coordinates histone amounts and genome content.
2021 Scientific Article in Genes and Development Genes Dev. 35, 1142-1160 (2021)
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation.
2021 Scientific Article in Genome Biology Genome Biol. 22:194 (2021)
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
2021 Scientific Article in ERJ Open Research ERJ Open Res. 7:00104-2021 (2021)
Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: Does it provide new insights?
2021 Scientific Article in Clinical Chemistry Clin. Chem. 67, 1153-1155 (2021)
Metabolomic fingerprints in large population cohorts: Impact of preanalytical heterogeneity.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 2944-2959.e10 (2021)
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin.
2021 Scientific Article in Nature metabolism Nat. Metab. 3, 1091-1108 (2021)
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development.
2021 Review in Life Life 11:637 (2021)
Consequences and resolution of transcription-replication conflicts.
2021 Nature Communications Nat. Commun. 12:4256 (2021)
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Nature Communications Nat. Commun. 12:4264 (2021)
Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy.
2021 Scientific Article in Genome Biology Genome Biol. 22:191 (2021)
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 53, 101295 (2021)
Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism.
2021 Scientific Article in Cardiovascular Research Cardiovasc. Res. 118:1742–1757 (2021)
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
2021 Review in Cell Systems Cell Syst. 12, 522-537 (2021)
Machine learning for perturbational single-cell omics.
2021 Scientific Article in Nature biomedical engineering Nat. Bio. Eng. 5, 1246-1260 (2021)
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
2021 Review in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 28, 100355 (2021)
Mechanistic models of blood cell fate decisions in the era of single-cell data.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:121 (2021)
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
2021 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 45, 633-650 (2021)
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3505 (2021)
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabi5781 (2021)
Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3987 (2021)
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 32, 1747-1763 (2021)
Plasma proteomics of renal function: A trans-ethnic metaanalysis and Mendelian randomization study.
2021 Scientific Article in Blood Blood 138, 1727-1732 (2021)
CHIP & HIPs: Clonal hematopoiesis is common in hip arthroplasty patients and associates with autoimmune disease.
2021 Review in EMBO Reports EMBO Rep. 22:e52774 (2021)
Histone acylations and chromatin dynamics: Concepts, challenges, and links to metabolism.
2021 Scientific Article in Nature Cell Biology Nat. Cell Biol. 23, 692-703 (2021)
Epithelial cell plasticity drives endoderm formation during gastrulation.
2021 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 28, 521-532 (2021)
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 7372–7383 (2021)
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression.
2021 Scientific Article in Nature Nature (2021)
Swarm Learning for decentralized and confidential clinical machine learning.
2021 Scientific Article in Plant Physiology Plant Physiol. 187, 336-360 (2021)
Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression.
2021 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:662056 (2021)
NG2-glia transiently overcome their homeostatic network and contribute to wound closure after brain injury.
2021 Review in Epigenomics Epigenomics 13, 981-984 (2021)
Epigenomics in the single cell era, an important read out for genome function and cell identity.
2021 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 20:111 (2021)
Metabolic syndrome and the plasma proteome: From association to causation.
2021 Scientific Article in STAR Protocols STAR Protoc. 2:100609 (2021)
Protocol for using heterologous spike-ins to normalize for technical variation in chromatin immunoprecipitation.
2021 Scientific Article in Heredity Heredity 127, 190–202 (2021)
Region-level epimutation rates in Arabidopsis thaliana.
2021 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 69, 185-192 (2021)
Neuronal replacement: Concepts, achievements, and call for caution.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 2793-2807.e8 (2021)
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.
2021 Review in Developmental Cell Dev. Cell 56, 1562-1573 (2021)
Decoding the organization, dynamics, and function of the 4D genome.
2021 Scientific Article in Nature Communications Nat. Commun. 12:2785 (2021)
Cellular connectomes as arbiters of local circuit models in the cerebral cortex.
2021 Review in BioSpektrum BioSpektrum 27, 246-249 (2021)
Dem Anfang auf der Spur — die Suche nach DNA-Replikationsursprüngen.
2021Vortrag: Cell Bio Virtual 2020, 2-16 December 2020, Virtual. (2021)
Coordination of mitochondrial homeostasis with cell size.
2021 Scientific Article in Diabetes Aktuell Diabetes akt. 19, 62-65 (2021)
Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes.
2021 Scientific Article in Diabetologia Diabetologia 64, 1850-1865 (2021)
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 6293-6304 (2021)
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
2021 Nature Cell Biology Nat. Cell Biol. 23, 566-576 (2021)
Author Correction: Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:7995 (2021)
Tens of images can suffice to train neural networks for malignant leukocyte detection.
2021 Scientific Article in British Journal of Dermatology - BJD Br. J. Dermatol. 185, 573-584 (2021)
Host traits, lifestyle and environment are associated with the human skin bacteria.
2021 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 17:e9923 (2021)
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.
2021 Scientific Article in Plant Science Plant Sci. 307:110860 (2021)
Cyanobacterial NOS expression improves nitrogen use efficiency, nitrogen-deficiency tolerance and yield in Arabidopsis.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1588 (2021)
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.
2021 Nature Nature 592:E1 (2021)
Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia.
2021 Scientific Article in Epidemiology Epidemiology 32, 378-388 (2021)
Deep learning-based propensity scores for confounding control in comparative effectiveness research: A large-scale, real-world data study.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 49:101188 (2021)
CD81 marks immature and dedifferentiated pancreatic β-cells.
2021 Scientific Article in Human Genetics and Genomics Advances HGG Advances 2:100013 (2021)
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits.
2021 Scientific Article in BMC Bioinformatics BMC Bioinformatics 22:103 (2021)
InstantDL: An easy-to-use deep learning pipeline for image segmentation and classification.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 13:e12871 (2021)
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Nature Nature 592:E8 (2021)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (Nature, (2020), 587, 7834, (377-386), 10.1038/s41586-020-2715-9).
2021 Scientific Article in iScience iScience 24:102120 (2021)
Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies.
2021 Nature Communications Nat. Commun. 12:995 (2021)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 PLoS Biology PLoS Biol. 19:e3001132 (2021)
Correction: Reoccuring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatio-temporal patterns.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:60 (2021)
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases.
2021 Review in Journal of Experimental Botany J. Exp. Bot. 72, 777-780 (2021)
The role of nitric oxide in plant biology: Current insights and future perspectives.
2021 Scientific Article in Cell Reports Cell Rep. 34:108742 (2021)
The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabe4497 (2021)
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation.
2021 Scientific Article in Journal of human genetics J. Hum. Genet. 66, 625–636 (2021)
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.
2021 Scientific Article in Nature Communications Nat. Commun. 12:24 (2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Nature Nature 590, 326–331 (2021)
Inceptor counteracts insulin signalling in β-cells to control glycaemia.
2021 Review in Nature Neuroscience Nat. Neurosci. 24, 312-325 (2021)
Reactive astrocyte nomenclature, definitions, and future directions.
Methods in Molecular Biology In: Epigenetic Reprogramming During Mouse Embryogenesis. 2021. 265-282 (Methods Mol. Biol. ; 2214)
DamID to map genome-protein interactions in preimplantation mouse embryos.
In: (2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), 13-16 April 2021, Nice, France). 2021. 966-970
Fourier transform of percol gradients boosts CNN classification ofhereditary hemolytic anemias.
2021 Scientific Article in Research Square Research Square, in press (2021)
DABC-Net for robust pneumonia segmentation and prediction of COVID-19 progression on chest CT scans.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e12461 (2021)
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1279 (2021)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1185 (2021)
Deep learning the collisional cross sections of the peptide universe from a million experimental values.
2021 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 141, 681-685.e6 (2021)
CD23 levels on B cells determine long-term therapeutic response in patients with atopic eczema treated with selective IgE immune apheresis.
2021 Editorial in Frontiers in Plant Science Front. Plant Sci. 12:639262 (2021)
Editorial: Highlights of POG 2019 - Plant Oxygen Group Conference.
2021 Scientific Article in Metabolites Metabolites 11:89 (2021)
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:7 (2021)
DNA methylation and lipid metabolism: An EWAS of 226 metabolic measures.
2021 Scientific Article in International Journal of Radiation Biology Int. J. Radiat. Biol. 97, 529-540 (2021)
Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice.
2021 Scientific Article in Cell Reports Cell Rep. 34:108748 (2021)
Dynamic adoption of anergy by antigen-exhausted CD4+ T cells.
2021 Scientific Article in Kidney International Kidney Int. 99, 926-939 (2021)
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
2021 Review in Journal of Experimental Botany J. Exp. Bot. 72, 808-818 (2021)
Nitric oxide signaling in the plant nucleus: The function of nitric oxide in chromatin modulation and transcription.
2021 Scientific Article in Science Science 371:eabb2986 (2021)
Characterization of a common progenitor pool of the epicardium and myocardium.
2021 Scientific Article in Nature Cell Biology Nat. Cell Biol. 23, 23-31 (2021)
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
2021 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 108, 284-294 (2021)
Genome-wide association study identifies novel susceptibility loci for KIT D816V positive mastocytosis.
2021 Scientific Article in Cell Cell 184, 709-722.e13 (2021)
Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2021 Review in Genes and Development Genes Dev. 35, 22-39 (2021)
TFs for TEs: The transcription factor repertoire of mammalian transposable elements.
2021 Scientific Article in EMBO Reports EMBO Rep. 22:e51009 (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.
2021 Review in Nucleic Acids Research Nucleic Acids Res. 49, 3020–3032 (2021)
Staying true to yourself: Mechanisms of DNA methylation maintenance in mammals
2021 Scientific Article in Life Science Alliance Life Sci. All. 4:e202000924 (2021)
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice.
2021 Scientific Article in Cell Stem Cell Cell Stem Cell 28, 524-534.e7 (2021)
CRISPR-mediated induction of neuron-enriched mitochondrial proteins boosts direct glia-to-neuron conversion.
2021 Scientific Article in Movement Disorders Mov. Disord. 36, 449-459 (2021)
Shared genetics of multiple system atrophy and inflammatory bowel disease.
2021 Review in Neurobiology of Disease Neurobiol. Dis. 148:105174 (2021)
Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 59–70 (2021)
Genome-wide association study identifies 48 common genetic variants associated with handedness.
2021 Scientific Article in Pediatric Allergy and Immunology Pediatr. Allergy Immunol. 32, 295-304 (2021)
Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors.
2021 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 2214, 175-187 (2021)
Mapping of chromosome territories by 3D-chromosome painting during early mouse development.
2021 Scientific Article in Glia Glia 69, 165-181 (2021)
Repetitive injury and absence of monocytes promote astrocyte self-renewal and neurological recovery.
2021 Review in Physiological Reviews Physiol. Rev. 101, 177-211 (2021)
CRISPR-tools for physiology & cell state changes - potential of transcriptional engineering and epigenome editing.
2021 Scientific Article in Glycobiology Glycobiology 31, 82-88 (2021)
Replication of fifteen loci involved in human plasma protein N-glycosylation in 4,802 samples from four cohorts.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 2111–2125 (2021)
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
2021 Scientific Article in Addiction Biology Addict. Biol. 26:e12855 (2021)
Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data.
2020 Review in EMBO Journal, The EMBO J. 39:e105725 (2020)
Thinking "ethical" when designing an international, cross-disciplinary biomedical research consortium.
2020 Review in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 142, 1-66 (2020)
The regulation of cortical neurogenesis.
2020 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 201:A5527 (2020)
Systemic biomarkers of lung function and FEV1 decline across multiple cohorts.
2020 BMC Public Health BMC Public Health 20:1335 (2020)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19) (vol 20, 1036, 2020).
Lecture Notes in Computer Science In:. 2020. 246-256 (Lect. Notes Comput. Sc. ; 12265 LNCS)
Attention based multiple instance learning for classification of blood cell disorders.
2020 Scientific Article in STAR Protocols STAR Protoc. 1:100228 (2020)
Microfluidics for single-cell lineage tracking over time to characterize transmission of phenotypes in Saccharomyces cerevisiae.
2020 Scientific Article in Cell Systems Cell Syst. 11, 653-662.e8 (2020)
H4K20 methylation is differently regulated by dilution and demethylation in proliferating and cell-cycle-arrested xenopus embryos.
Lecture Notes in Computer Science In:. 2020. 174-183 (Lect. Notes Comput. Sc. ; 12265 LNCS)
Background and illumination correction for time-lapse microscopy data with correlated foreground.
2020 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 48, 11335-11346 (2020)
Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 2, i610-i617 (2020)
Conditional out-of-distribution generation for unpaired data using transfer VAE.
2020 Scientific Article in Frontiers in Immunology Front. Immunol. 11:606338 (2020)
Specific induction of double negative B cells during protective and pathogenic immune responses.
Acta Horticulturae In:. 2020. 455-462 (Acta Hortic. ; 1297)
Transformation of Nicotiana tabacum using the herbicide resistance bar gene as a selectable marker.
2020 Review in Annual Review of Genetics Annu. Rev. Genet. 54, 167-187 (2020)
Measuring and modeling single-cell heterogeneity and fate decision in mouse embryos.
2020 Scientific Article in Nature Nature 588, 466-472 (2020)
Cells of the adult human heart.
2020 Review in Tumor Diagnostik und Therapie Tumordiagnos. Ther. 41, 666-668 (2020)
Zytomorphologische Diagnostik mithilfe von künstlicher Intelligenz (KI).
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In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning.
2020 Scientific Article in PLoS Biology PLoS Biol. 18:e3000708 (2020)
Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns.
2020 Scientific Article in Photoacoustics Photoacoustics 20:100203 (2020)
A sparse deep learning approach for automatic segmentation of human vasculature in multispectral optoacoustic tomography.
2020 Scientific Article in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 12396 LNCS, 105-114 (2020)
Learning Tn5 sequence bias from ATAC-seq on naked chromatin.
2020 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 48, 11394-11407 (2020)
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
2020 Scientific Article in Genome Biology Genome Biol. 21:259 (2020)
A genome assembly and the somatic genetic and epigenetic mutation rate in a wild long-lived perennial Populus trichocarpa.
2020 Scientific Article in Genome Biology Genome Biol. 21:33023650 (2020)
AlphaBeta: Computational inference of epimutation rates and spectra from high-throughput DNA methylation data in plants.
2020 Scientific Article in iScience iScience 23:101601 (2020)
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2020 Scientific Article in Nature Communications Nat. Commun. 11:5653 (2020)
Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin.
2020 Scientific Article in Nature machine intelligence Nat. Mach. Intell. 2, 719-726 (2020)
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2020 Scientific Article in Nature Nature 588, 151–156 (2020)
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
2020 Scientific Article in Nature Genetics Nat. Genet. 52, 1151-1157 (2020)
Regulation of single-cell genome organization into TADs and chromatin nanodomains.
2020 Scientific Article in Advanced materials Adv. Mater. 32:e2003913 (2020)
Prediction of chronic inflammation for inhaled particles: The impact of material cycling and quarantining in the lung epithelium.
2020 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 8:587778 (2020)
Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling.
2020 Scientific Article in Communications Biology Comm. Biol. 3:628 (2020)
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
2020 Scientific Article in Frontiers in Plant Science Front. Plant Sci. 11:549913 (2020)
Improving air quality by nitric oxide consumption of climate-resilient trees suitable for urban greening.
2020 Review in Nature Nature 587, 377–386 (2020)
LifeTime and improving European healthcare through cell-based interceptive medicine.
2020 Scientific Article in Science Advances Sci. Adv. 6:eaaz4551 (2020)
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth.
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miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
2020 Review in Development / Company of Biologists Development 147:dev189688 (2020)
The molecular and cellular features of 2-cell-like cells: a reference guide.
2020 Scientific Article in Glia Glia 69, 346-361 (2020)
Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.
2020 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 16:e9416 (2020)
Predicting antigen specificity of single T cells based on TCR CDR3 regions.
2020 Scientific Article in Diabetes Diabetes 69, 2756-2765 (2020)
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
2020 Scientific Article in Royal Society Open Science R. Soc. Open Sci. 7:200701 (2020)
Ectopic fat accumulation in human astrocytes impairs insulin action.
2020 Scientific Article in Diabetes Diabetes 69, 2766-2778 (2020)
Deciphering the plasma proteome of type 2 diabetes.
2020 Review in Current Genetics Curr. Genet. 66, 1029–1035 (2020)
The past determines the future: Sugar source history and transcriptional memory.
2020 Scientific Article in Nature Communications Nat. Commun. 11:3559 (2020)
Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis.
2020 Scientific Article in Annals of Neurology Ann. Neurol. 88, 736-746 (2020)
Circulating metabolites differentiate acute ischemic stroke from stroke mimics.
2020 Scientific Article in Nature Biotechnology Nat. Biotechnol. 38, 1408–1414 (2020)
Generalizing RNA velocity to transient cell states through dynamical modeling.
2020 Review in Trends in Molecular Medicine Trends Mol. Med. 26, 890-892 (2020)
Neuronal reprogramming for brain repair: Challenges and perspectives.
2020 Scientific Article in Aging Aging 12, 15222-15259 (2020)
Global variability of the human IgG glycome.
2020 Scientific Article in Lancet Respiratory Medicine, The Lancet Resp. Med. 8, 696-708 (2020)
Chronic obstructive pulmonary disease and related phenotypes: Polygenic risk scores in population-based and case-control cohorts.
2020 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 130, 6093-6108 (2020)
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
2020 Scientific Article in Nature Cell Biology Nat. Cell Biol. 22, 767-778 (2020)
Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3.
2020 Editorial in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)
Introduction to mammalian genome special issue: Epigenetics.
2020 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 64, 26-30 (2020)
A cell in hand is worth two in the embryo: Recent advances in 2-cell like cell reprogramming.
2020 Scientific Article in EMBO Journal, The EMBO J.:e103373 (2020)
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
2020 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 147, 587-599 (2020)
Inflammatory macrophage memory in nonsteroidal anti-inflammatory drug–exacerbated respiratory disease.
2020 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 48, 8393-8407 (2020)
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
2020 Scientific Article in BMC Public Health BMC Public Health 20:1036 (2020)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19).
2020 Scientific Article in Molecular Metabolism Mol. Metab. 40:101038 (2020)
Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.
2020 Review in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 18, 1330-1341 (2020)
Seq-ing answers: Current data integration approaches to uncover mechanisms of transcriptional regulation.
2020 Scientific Article in Nature Nature 582, 592–596 (2020)
The proteome landscape of the kingdoms of life.
2020 Scientific Article in Nature Communications Nat. Commun. 11:3068 (2020)
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces.
2020 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 17:27 (2020)
Influence of wood species on toxicity of log-wood stove combustion aerosols: A parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.
2020 Scientific Article in Nature Communications Nat. Commun. 11:2952 (2020)
Cell size sets the diameter of the budding yeast contractile ring.
2020 Scientific Article in Molecular Cell Mol. Cell 78, 915-925 (2020)
Single-cell tracing dissects regulation of maintenance and inheritance of transcriptional reinduction memory.
2020 Review in New Phytologist New Phytol. 227, 1319-1325 (2020)
Regulating the regulator: Nitric oxide control of post-translational modifications.
2020 Review in Frontiers in Genetics Front. Genet. 11:450 (2020)
Proximity labeling techniques to study chromatin.
Informatik aktuell In: Bildverarbeitung für die Medizin 2020. 2020. 53-54 (Inf. aktuell)
Abstract: Recognition of AML blast cells in a curated single-cell dataset of leukocyte morphologies using deep convolutional neural networks.
2020 Scientific Article in Cell Cell 181, 1016-1035 (2020)
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.
2020 Review in Current opinion in pharmacology Curr. Opin. Pharmacol. 53, 35-44 (2020)
Anti-inflammatory glucocorticoid action: Genomic insights and emerging concepts.
2020 Review in Molecular Metabolism Mol. Metab. 38:100951 (2020)
Interactions between metabolism and chromatin in plant models.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 4296-4300 (2020)
COMUNET: A tool to explore and visualize intercellular communication.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Scientific Article in Nature Communications Nat. Commun. 11:2306 (2020)
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
2020 Scientific Article in Acta Physiologica Acta Physiol. 230:e13496 (2020)
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
2020 Scientific Article in Cell Systems Cell Syst. 10, 363-378.e12 (2020)
Gene networks with transcriptional bursting recapitulate rare transient coordinated high expression states in cancer.
2020 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 12:e11419 (2020)
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
2020 Scientific Article in Nature medicine Nat. Med. 26, 681–687 (2020)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
2020 Review in Molecular Metabolism Mol. Metab. 38:100987 (2020)
You are what you eat-How nutrition and metabolism shape the genome through epigenetics.
2020 Nature metabolism Nat. Metab. 2, 380 (2020)
Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission (Nature Metabolism, (2020), 2, 2, (192-209), 10.1038/s42255-020-0171-3).
2020 Scientific Article in Nature Biotechnology Nat. Biotechnol. 38, 1061–1072 (2020)
Generation of pancreatic β cells from CD177+ anterior definitive endoderm.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A16-A16 (2020)
Scar formation is driven by N-cadherin dependent collective fibroblast migration.
2020 Review in Mammalian Genome Mamm. Genome 31, 119–133 (2020)
Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.
2020 Scientific Article in Current Biology Curr. Biol. 30, 1142-1151 (2020)
Epithelial planar bipolarity emerges from Notch-mediated asymmetric inhibition of Emx2.
2020 Review in Genome Biology Genome Biol. 21:31 (2020)
Eleven grand challenges in single-cell data science.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A7-A7 (2020)
Fate trajectory modeling reveals convergence of airway derived progenitors and AT2 cells on transient KRT8+alveolar cell state during lung regeneration.
2020 Review in Philosophical Transactions of the Royal Society of London. Series B Philos. Trans. R. Soc. B - Biol. Sci. 375:20190339 (2020)
On transposons and totipotency.
2020 Scientific Article in eLife eLife 9:e52155 (2020)
The single-cell eQTLGen consortium.
2020 Scientific Article in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 4291-4295 (2020)
Automatic identification of relevant genes from low-dimensional embeddings of single-cell RNA-seq data.
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The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
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Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length.
2020 Scientific Article in Cell Reports Cell Rep. 30, 1223-1234 (2020)
Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 methylation landscapes.
2020 Review in Nature Nature 578, 522-524 (2020)
Turning connective tissue into neurons for 10 years.
2020 Review in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 14:32 (2020)
Filling the gaps - A call for comprehensive analysis of extracellular matrix of the glial scar in region- and injury-specific contexts.
2020 Scientific Article in Life Science Alliance Life Sci. All. 3:e201900499 (2020)
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition.
2020 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 16:e1007147 (2020)
Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines.
2020 Scientific Article in Diabetes Care Diabetes Care 43, 875-884 (2020)
Epigenetic link between statin therapy and type 2 diabetes.
2020 Nature Plants Nat. Plants 6:328 (2020)
Author Correction: Widespread long-range cis-regulatory elements in the maize genome.
2020 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 16:e1007616 (2020)
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning.
In: Beyond Our Genes. 2020. 175-208
The (not so) controversial role of DNA methylation in epigenetic inheritance across generations.
2020 Scientific Article in Nature metabolism Nat. Metab. 2, 192-209 (2020)
Targeted pharmacological therapy restores β-cell function for diabetes remission.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0227648 (2020)
Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples.
2020 Scientific Article in Nature Communications Nat. Commun. 11:15 (2020)
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
2020 Scientific Article in Cell Stem Cell Cell Stem Cell 26, 277-293.e8 (2020)
Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis.
2020 Scientific Article in Molecular Cell Mol. Cell 77, 294-309.e9 (2020)
MeCP2 represses the rate of transcriptional initiation of highly methylated long genes.
2020 Scientific Article in EMBO Reports EMBO Rep. 21:e48354 (2020)
A distinct metabolic state arises during the emergence of 2-cell-like cells.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 1260-1261 (2020)
breakpointR: An R/Bioconductor package to localize strand state changes in Strand-seq data.
2020 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 145, 1208-1218 (2020)
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
2020 Scientific Article in Annals of Neurology Ann. Neurol. 87, 184-193 (2020)
Identification of restless legs syndrome genes by mutational load analysis.
2020 Scientific Article in Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 34, 800-809 (2020)
IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.
2020 Review in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1863:194444 (2020)
Gene networks in cancer are biased by aneuploidies and sample impurities.
2020 Review in New Phytologist New Phytol. 225, 1828-1834 (2020)
Recommendations on terminology and experimental best practice associated with plant nitric oxide research.
2020 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 59, 1357-1369 (2020)
Modifying effect of metabotype on diet-diabetes associations.
2020 Scientific Article in Thorax Thorax 75, 184-187 (2020)
Altered relaxation times in MRI indicate bronchopulmonary dysplasia.
2020 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 21, 272-281 (2020)
Copy number aberrations from Affymetrix SNP 6.0 genotyping data-how accurate are commonly used prediction approaches?
In: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. 2019. 309-347
Omics: Potential role in early phase drug development.
2019Poster: Intestinal organoids - from stem cells to metabolism and microbiome interactions, 29 September 2019, Kopenhagen. (2019)
Gradual pioneer factor expression resolves enteroendocrine lineage recruitment from intestinal stem cells.
2019 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 29, S7-S8 (2019)
Brain organoids as models of the developing human brain: deciphering the molecular signature of prenatal stress.
2019 GigaScience GigaScience 8:giz162 (2019)
A network-based conditional genetic association analysis of the human metabolome (vol 7, gij137, 2018).
2019 Meeting abstract in Glia Glia 67, E689-E690 (2019)
Tlr2 and Cxcr3 pathways modulate scar formation after traumatic brain injury.
2019 Meeting abstract in Glia Glia 67, E693-E693 (2019)
Injury-induced plasticity of parenchymal astrocytes in the human cerebral cortex.
2019 Meeting abstract in Glia Glia 67, E758-E758 (2019)
Lrp1 loss in radial glia and their progeny - astrocytic dysfunctions contribute to spontaneous epileptogenesis.
2019 Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 33, 2380-2380 (2019)
Is the humoral immunity dispensable for the pathogenesis of psoriasis? (vol 33, pg 115, 2019).
2019 Other: Opinion in Informatik-Spektrum Inf.-Spektrum, DOI: 10.1007/s00287-019-01220-y (2019)
Munich School for Data Science (MUDS) – Eine Graduiertenschule für Data Science in München.
2019 Scientific Article in Nature Plants Nat. Plants 5, 1237-1249 (2019)
Widespread long-range cis-regulatory elements in the maize genome.
2019 Scientific Article in Nature Communications Nat. Commun. 10:5121 (2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
2019 Scientific Article in Nature machine intelligence Nat. Mach. Intell. 1, 538-544 (2019)
Human-level recognition of blast cells in acute myeloid leukemia with convolutional neural networks.
2019 Scientific Article in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11764 LNCS, 676-684 (2019)
Multi-task learning of a deep K-nearest neighbour network for histopathological image classification and retrieval.
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Multiclass deep active learning for detecting red blood cell subtypes in brightfield microscopy.
2019 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-019-0341-8 (2019)
Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes (Nature Structural & Molecular Biology, (2019), 26, 10, (899-909), 10.1038/s41594-019-0293-z).
In: (Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019, 23-27 June 2019, Munich, Germany). 2019.:8871546
Broadband IR-fingerprinting of human blood as a universal tool for diseases diagnostics.
2019 Scientific Article in EMBO Reports EMBO Rep. 20:e47952 (2019)
Expression and phase separation potential of heterochromatin proteins during early mouse development.
2019 Scientific Article in Nature Communications Nat. Commun. 10:4957 (2019)