New Article published in Nature

In this study, we introduce the small molecule compound class of 3-phenylquinazolinones, termed icFSP1, as the first in vivo active ferroptosis suppressor protein-1 (FSP1)-specific inhibitors. The inhibitor molecule icFSP1 induces subcellular relocalization of FSP1 from membranes and phase separation prior to lipid peroxidation and ferroptosis. Our results elucidate a link between the process of phase separation and ferroptosis and should spur future efforts to develop in vivo applicable drugs for the treatment of certain cancers considered to be vulnerable to ferroptosis.
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