Jewelry picture lung examination in clinic

HI-MAG combines innovative research approaches for the prevention, diagnosis and treatment of obesity and other metabolic and vascular diseases with the comprehensive infrastructure of Leipzig University Medicine. The voluntary provision of tissue samples and data by study participants, as well as their participation in further scientific studies, enables a close link between research and clinical therapy in close cooperation with the Medical Faculty of the Leipzig University and the University of Leipzig Medical Center.

We are looking for volunteers for clinical studies on human metabolic processes.

At the Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), clinical projects are carried out by the Medical Faculty of the University of Leipzig in cooperation with Helmholtz Zentrum München.

Registration and Further Information

many color bright candies on female tongue

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übergewichtige junge frau trainiert mit hanteln

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Hand holding a paper sheet with transgender symbol

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Closeup of a atherosclerosis- 3D rendering

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Research Female Scientist is using a Microscope and a Tablet Computer while Working in a Modern Laboratory. Doing Genetic and Pharmaceutical Researches.

See the studies here

Messung des Bauchumfangs in der Studienambulanz des HI-MAG

The determination of anthropmetric measurements, e. g. B. body weight, height and girth, enables a basic characterization of the person.

Blood and urine values provide information about the state of health. Indications of a possible disease and disease risks as well as therapy effects can in this way be monitored.

BIA-Messung in der Studienambulanz des HI-MAG, Leipzig

Bioelectrical impedance analysis is an electrical resistance measurement of the human body and allows the proportions of muscle and fat tissue in the human body to be estimated, as well as the body fat content.

When measuring blood pressure, the pressure in the arteries is measured to determine the systolic and diastolic blood pressure. This provides an indication of possible hypertension and the associated risk of cardiovascular disease.

doctor shows the dilation of small blood vessels of the skin on the leg. Medical inspection and treatment of Telangiectasia. sclerotherapy procedure

This method can be used to determine the functionality of the venous valves, e.g. in the case of varicose veins.

Doktor kontrolliert Patient EKG in Arztpraxis

In this measurement, the sum of the electrical activity of all heart muscle fibres is displayed graphically. This allows a variety of conclusions to be drawn about heart function.

The endothelial measurement is used to assess arterial stiffness and provides information on endothelial function.

With the help of dietyry protocols, eating behaviour at home can be recorded qualitatively and quantitatively and macro and micro nutrients of the food consumed can be quantified using software.

Different aspects of eating behaviour such as feelings of hunger, conscious restriction of food intake, intuitive eating and pathological eating behaviour are recorded using a battery of tests with various questionnaires on eating behaviour.

Arzt bei der Durchführung eines Gefäßultraschalls

This method can be used to detect organic and functional vascular changes in both the arterial and venous areas.

Geruchtstest in der Studienambulanz des HI-MAG

The sense of smell is measured qualitatively using various odor samples.

The sense of taste is measured qualitatively and quantitatively using various taste strips.

This method is used to assess tissue oxygen saturation and provides information on microcirculation.

Durchführung einer Indirekten Kalorimetrie in der Studienambulanz des HI-MAG, Leipzig

Indirect calorimetry is a method of measuring the oxygen consumption of an organism. This technique is used to determine the organism's energy metabolism.

Close up of hand touching smartwatch with health app on the screen, gadget for fitness active lifestyle.

Acceleration sensors in the form of a wristband are used to measure physical activity throughout the day.

Captivating 3D close-up of human cardiovascular system

This method is used to analyze the microcirculation.

Blood pressure measurement from the popliteal artery leg,

This measurement is a screening method for the presence of peripheral arterial occlusive disease (PAD).

Woman using glucometer on blue background, top view

Oral glucose tolerance test, insulin clamp test: These tests measure the body's insulin sensitivity and insulin response to carbohydrates.

A detailed view of the complex network of blood vessels in a biological sample

This method allows the blood flow in the finger and toe arteries to be assessed.

Pulse wave analysis is used to assess arterial stiffness and provides information on endothelial function.

Nahrungsmittelallergie Allergie gegen Nahrungsmittel

The snack-food-taste-test is used to qualitatively and quantitatively record the intake of certain foods in an already saturated state.

Healthy or vegetarian nutrition concept with selection of organic autumn fruits and vegetables on rustic wooden table

The standardized test meal is used to qualitatively and quantitatively record the calorie intake of certain foods with the possibility of differentiating between the various macronutrients in a hungry state.

This method is used to measure the outflow of venous blood and provides information about any obstacles to outflow, e.g. after a thrombosis.

More information on the study

Röhrborn K, Krueger M, Kalusa M, Fietz SA, Ewe A, Aigner A, Stumvoll M, Kovacs P, Blüher M, Schamarek I, Rohde-Zimmermann K

The concentration of salivary extracellular vesicles is related to obesity.

Schamarek I, Richter FC, Finlayson G, Tönjes A, Stumvoll M, Blüher M, Rohde-Zimmermann K

Association of salty and sweet taste recognition with food reward and subjective control of eating behavior.

Kersten A, Lorenz A, Nottmeier C, Schmidt M, Roesner A, Richter FC, Röhrborn, K, Witte AV, Hahnel S, Koehne, T, Blüher M, Stumvoll M, Rohde-Zimmermann K, Schamarek I

The Obese Taste Bud study: Objectives and study design.

Blüher M, Rosenstock J, Hoefler J, Manuel R, Hennige AM

Dose-response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial.

Branzan D, Geisler A, Steiner S, Scheinert D, Funk K, Schmidt A

Endovascular occlusion of segmental arteries feeding the anterior spinal artery to stage endovascular thoracoabdominal aortic repair.

Schamarek I, Richter F, Tönjes A, Stumvoll M, Blüher M, Rohde-Zimmermann K, Finlayson G

The German Leeds food preference Questionnaire (LFPQ-G): A validation study.

Michel S, Linder N, Linder A, Eggebrecht T, Schaudinn A, Blüher M, Dietrich A, Denecke T, Busse H

Anthropometric estimators of abdominal fat volume in adults with overweight and obesity.

Home PD, McCrimmon RJ, Rosenstock J, Blüher M, Pegelow K, Melas-Melt L, Djaballah K, Giorgino F; SoliMix trial investigators

Findings for iGlarLixi versus BIAsp 30 confirmed in groups of people with type 2 diabetes with different biomedical characteristics.

Wittig T, Schmidt A, Fuß T, Thieme M, Maiwald L, Düsing S, Konert M, Fischer A, Scheinert D, Steiner S

Randomized Trial Comparing a Stent-Avoiding With a Stent-Preferred Strategy in Complex Femoropopliteal Lesions.

Hammel MC, Stein R, Kratzsch J, Vogel M, Eckert AJ, Triatin RD, Colombo M, Meigen C, Baber R, Stanik J, Spielau U, Stoltze A, Wirkner K, Tönjes A, Snieder H, Holl RW, Stumvoll M, Blüher M, Kiess W, Körner A

Fasting indices of glucose-insulin-metabolism across life span and prediction of glycemic deterioration in children with obesity from new diagnostic cut-offs.

Stein R, Koutny F, Riedel J, Dörr N, Meyer K, Colombo M, Vogel M, Anderwald CH, Blüher M, Kiess W, Körner A, Weghuber D

Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity

Heinitz S, MÜller J, Jenderka KV, Schlögl H, Stumvoll M, Blüher M, Blank V, Karlas T

The application of high-performance ultrasound probes increases anatomic depiction in obese patients

Kempf E, Landgraf K, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tsen YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.

Stein R, Göpel E, Weghuber D, Hammel MC, Vogel M, Kiess W, Körner A

Are there relevant thresholds of insulin-independent indices across the lifespan to predict alterations in glycemic control?—

Lange UG, Moulla Y, Schütz T, Blüher M, Peter V, Shang E, Dietrich A

Effectiveness and Tolerability of a Two-Week Hypocaloric Protein-Rich Diet Prior to Obesity Surgery with Two Different Diet Interventions: a Prospective Randomized Trial.

Karlas T, Petroff D, Feisthammel J, Beer S, Blüher M, Schütz T, Lichtinghagen R, Hoffmeister A, Wiegand J

Endoscopic Bariatric Treatment with Duodenal-Jejunal Bypass Liner Improves Non-invasive Markers of Non-alcoholic Steatohepatitis.