We strive to understand how genomes coordinate transcription within the context of nuclear organization to guide complex developmental decisions. We create novel tools and approaches for single-cell biology.

Our research is dedicated to the development of excellent techniques for biomedical imaging. The advancement of new targeted contrast agents and novel imaging modalities will pave the way for personalized therapy.

We are a diverse team of researchers asking interdisciplinary questions, and engaging in multidisciplinary approaches, in the hopes of achieving transdisciplinary outcomes (transcending disciplines).

Marion´s Team uses in situ cryo-electron tomography methodologies, including correlative cryo-focused ion beam milling sample preparation and image processing to reveal actin architectures directly inside the native cellular environment.

Combining engineering and biological approaches, Matthias lab aims to understand the role of natural stem cell niches mechanistically and simulate /manipulate them reproducibly unde rlaboratory conditions. 

Celia´s lab aims to differentiated "molecular age" and "chronological age". Novel molecular featureswill be useful to decipher the impact of cellular variability on tissue function, during ageing and in chronic diseases.