Global Platform for the Prevention of Autoimmune Diabetes (GPPAD)
GPPAD is an European platform to identify infants with an elevated genetic risk of developing type 1 diabetes, and to perform primary prevention trials aiming to reduce the incidence of islet autoimmunity and type 1 diabetes in children.
GPPAD is an European platform to identify infants with an elevated genetic risk of developing type 1 diabetes, and to perform primary prevention trials aiming to reduce the incidence of islet autoimmunity and type 1 diabetes in children.
GPPAD Studies
Newborn screening for genetic predisposition of type 1 diabetes using a polygenic 51 SNP risk score
Freder1k study
Primary prevention study to determine whether vaccinating children with an elevated genetic risk for type 1 diabetes against SARS-CoV influences immune development, beta-cell function, and the risk of islet autoimmunity
AVAnT1A study
Primary intervention study to determine whether daily administration of B. infantis EVC001 until age 12 months to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies in childhood
SINT1A study
Primary intervention study to determine whether daily administration of oral insulin to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies and diabetes in childhood
POInT study
The GPPAD Coordination Center is located at Helmholtz Munich with the following structure and organizational departments:
Regulatory Affairs
Responsible for regulatory and ethical committee submissions, study documents and tools, TMF maintenance, management of monitoring and audits, central data review and data cleaning, coordination of external vendors, SOPs and IMP management.
Biometrics & statistics
Responsible for trial design, interim reports and analysis. Oversees recruitment, and development of endpoints.
Contact Andreas WeißDatabase & biosample management
Responsible for database and data integrity, logistics, LIMS, data and query management.
Contact Florian HauptPharmacy & IMP
Oversees IMP/ study product manufactory activities.
Contact with pharmacy and manufacturers.
Central laboratory
Responsible for SOP sample collection/ processing/storage, laboratory measurements and logistics, result reporting, biobank and storage management.
Contact to central laboratories and central biobank.
Medical oversight, safety & study outcomes
Responsible for medical monitoring of safety data and study outcomes. Overall responsibility for successful study conduct generating reliable data of scientific value.
Contact Anette-G. ZieglerCentral office
Responsible for general communication, PR activities, homepage design and content, event management, finances and contracts.
Contact Melanie GündertContact
Institutsdirektorin, Lehrstuhl für Diabetes und Gestationsdiabetes, Klinikum rechts der Isar und Technische Universität München, Direktorin Globale Plattform zur Prävention des Autoimmunen Diabetes (GPPAD)
anettegabriele.zieglerspam prevention@helmholtz-munich.de
Heidemannstraße 1, 80939 München