The research group of Prof. Ferruh Artunc, MD, focuses on the importance of the excretion of active proteases in the urine in nephrotic syndrome, which has been termed proteasuria. Current data suggest that proteasuria plays an important pathophysiological role in the development of typical complications of nephrotic syndrome such as sodium retention, hyperlipidaemia, hypercoagulability and progressive renal injury. The identification of the proteases involved could lay the foundation for new therapeutic approaches to treat patients with nephrotic syndrome by targeted inhibition of protease activity in the urine. In the nephrotic mouse model, this achieved a complete prevention of sodium retention without quantitatively reducing proteinuria (Bohnert et al. Kidney International 2018).
Professional Background
Conferral of the title of associate professor
Senior physician
Habilitation
Specialist for internal medicine
Honors and Awards
- Paul Langerhans Prize of the German Diabetes Society 2023
- Nils Alwall Prize of the German Society for Nephrology 2019
- Special Award of the Scientific Institute of Nephrology 2018
- Abstract Prize 2018, 10th Annual Meeting of the German Society of Nephrology 2018
- Poster Prize 2013, 5th Annual Meeting of the German Society for Nephrology 2013
Publications
Essigke, D. ; Kalo, M.Z. ; Janessa, A. ; Bohnert, B.N. ; Li, X. ; Birkenfeld, A.L. ; Artunc, F.
Impact of aldosterone deficiency on the development of diuretic resistance in mice.Eisinger, F. ; Neumann, M. ; Wörn, M. ; Fritsche, A. ; Heyne, N. ; Peter, A. ; Birkenfeld, A.L. ; Jumpertz von Schwartzenberg, R. ; Artunc, F.
Comparison of GFR estimation in patients with diabetes mellitus using the EKFC and CKD-EPI equations.Bissinger, R. ; Schaefer, L. ; Bohnert, B.N. ; Schork, A. ; Hörber, S. ; Peter, A. ; Qadri, S.M. ; Birkenfeld, A.L. ; Heyne, N. ; Bakchoul, T. ; Wieder, T. ; Artunc, F.
GFR is a key determinant of red blood cell survival in anemia associated with progressive CKD.Artunc, F.
Update Kontraindikationen Peritonealdialyse. Ansätze zur Überwindung relativer Kontraindikationen.Artunc, F.
Update Kontraindikationen Peritonealdialyse. Ansätze zur Überwindung relativer Kontraindikationen.Sure, F. ; Afonso, S. ; Essigke, D. ; Schmidt, P. ; Kalo, M.Z. ; Nesterov, V. ; Kißler, A. ; Bertog, M. ; Rinke, R. ; Wittmann, S. ; Broeker, K.A.E. ; Gramberg, T. ; Artunc, F. ; Korbmacher, C. ; Ilyaskin, A.V.
Transmembrane serine protease 2 and proteolytic activation of the epithelial sodium channel in mouse kidney.Schork, A. ; Eberbach, M.-L. ; Artunc, F. ; Bohnert, B.N. ; Eisinger, F. ; Heister, D.J. ; Vosseler, A. ; Nadalin, S. ; Birkenfeld, A.L. ; Heyne, N. ; Guthoff, M.
SGLT2 inhibitors correct fluid overload in adult kidney transplant recipients-A prospective observational study.Schork, A. ; Vogel, E. ; Bohnert, B.N. ; Essigke, D. ; Wörn, M. ; Fischer, I. ; Heyne, N. ; Birkenfeld, A.L. ; Artunc, F.
Amiloride versus furosemide for the treatment of edema in patients with nephrotic syndrome: A pilot study (AMILOR).Schork, A. ; Eberbach, M.L. ; Bohnert, B.N. ; Wörn, M. ; Heister, D.J. ; Eisinger, F. ; Vogel, E. ; Heyne, N. ; Birkenfeld, A.L. ; Artunc, F.
SGLT2 inhibitors decrease overhydration and proteasuria in patients with chronic kidney disease: A longitudinal observational study.Artunc, F.
Pleuroperitoneal leakage – Is this the end of peritoneal dialysis?
