Dr. Ingo Burtscher; Deputy Director and Group Leader, Stem Cell Research, Institute of Diabetes and Regeneration Research (IDR)

Deputy director and Group Leader Stem Cell Research

Dr. Ingo Burtscher

Research focus and Academic Career

Ingo Burtscher did his undergraduate studies of Molecular Biology and Microbiology at the University of Vienna. For his Master's thesis, he went in to the Institute of Molecular Pathology (IMP) in the group of Gerhard Christofori, where he studied PI3  kinase survival pathways in insulinoma cells. During this time, he discovered his interest in cloning and generated his first transgenic mouse line.

For his PhD, he went to Queen Mary and Westfield College at the University of London, where he studied in the group of Dean Nizetic the protein function of a ubiquitin-specific protease. During this time, he generated fluorescent fusion proteins and used them for microscopy and time-lapse imaging.

In 2005, Ingo Burtscher started his postdoc in the Stem Cell Institute in the Junior Group of Dr. Heiko Lickert, where he studied the formation of the endoderm layer during gastrulation of the mouse. He generated numerous fluorescent reporter mouse lines that allowed a deeper analysis during the formation of the endoderm.

In 2013, the Institute of Diabetes and Regeneration (IDR) was founded, and Ingo took on the role as Deputy Director and Group leader of the stem cell group. The research focus shifted from mouse development toward more translational work using human stem cells. Again, he and his team generated numerous fluorescent reporter lines, this time using human induced pluripotent stem cells (iPSCs). The current questions being tackled in his team are endocrine lineage decisions of the human pancreas, maturation of beta cells, and understanding the pancreatic endocrine niche and its role for beta cell function.

Expertise

CRISPR/Cas 9 iPSC fluorescent reporter lines Beta cell biology Beta cell differentiation Pancreas development Beta cell replacement therapies disease modeling and drug screening

Mission

Professional Career

Since 2012

Head of the group Stem Cell Research

Institute of Diabetes and Regeneration Research, Helmholtz Munich

2005-2012

Postdoc in Endoderm Research

Stem Cell Institute, Helmholtz Munich

2000-2004

PhD student

Queen Mary & Westfield College, University of London

1993-1999

Diploma studies in Biology

University of Vienna

Most Important Publications

2021 Nat Cell Biol

Scheibner K, Schirge S, Burtscher I, Büttner M, Sterr M, Yang D, Böttcher A, Ansarullah, Irmler M, Beckers J, Cernilogar FM, Schotta G, Theis FJ, Lickert H.

Epithelial cell plasticity drives endoderm formation during gastrulation
2021 Int. J. Mol. Sci

Burtscher, I.; Tarquis-Medina, M.; Salinno, C.; Schirge, S.; Beckenbauer, J.; Bakhti, M.; Lickert, H

Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line
2021 CRISP J

Shahryari A, Moya N, Siehler J, Wang X, Burtscher I, Lickert H.

Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells
2020 Stem Cell Res

Siehler J, Blöchinger AK, Akgün M, Wang X, Shahryari A, Geerlof A, Lickert H, Burtscher I.

Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8)
2020 Stem Cell Res

Moya N, Shahryari A, Burtscher I, Beckenbauer J, Bakhti M, Lickert H.

Generation of a homozygous ARX nuclear CFP (ARXnCFP/nCFP) reporter human iPSC line (HMGUi001-A-4)
2016 Stem Cell Res

Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Lickert H.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene
2017 Mol Metab

Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H.

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells
2016 Mech Dev.

Willmann SJ, Mueller NS, Engert S, Sterr M, Burtscher I, Raducanu A, Irmler M, Beckers J, Sass S, Theis FJ, Lickert H.

The global gene expression profile of the secondary transition during pancreatic development
2012 Genesis

Burtscher I, Barkey W, Schwarzfischer M, Theis FJ, Lickert H

The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development

Networks and Affiliations

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