Molecular model of immunoglobulin

Junior Group Leader Integrative Data Science

Luise Rauer

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Research Areas

During her studies in Human Biology and Public Health, Luise Rauer developed a strong passion for methodology-driven research and disentangling biological signals in complex data. In her PhD, she investigated how methodological choices in both data generation and analysis shape scientific conclusions in microbiome research. She characterized previously underrecognized critical confounders in microbiome data analysis and developed new computational approaches to minimize biases introduced by laboratory contamination and DNA extraction procedures. Her findings emphasized the need for greater standardization and transparency in the field.

Now leading the junior research group "Integrative Data Science", Luise focuses on how microbiome data can be more reliably applied to clinical research questions by developing holistic frameworks to mitigate systematic biases. Her broader mission includes promoting scientific standards and implementing FAIR principles to strengthen the long-term value of microbiome research and related disciplines.

Fields of Work and Expertise

Microbiome  Standardization Metascience 

Bioinformatics Computational Biology  

Professional Career

2025 - Now

Junior Group Leader Integrative Data Science

2019 - 2024

PhD thesis (Dr. rer. nat.) at the Institute of Environmental Medicine, Technical University of Munich and Helmholtz Munich, titled “Overcoming bias in microbiome sequencing data – a computational and laboratory framework”

2016 - 2019

Master of Science in Public Health, Ludwig Maximilian University of Munich, including a term abroad at Université de Bordeaux, France

2012 - 2016

Bachelor of Science in Human Biology, including a term abroad at Lund University, Sweden

Awards and Scholarships

  • 2023 Dr. Wolfbauer Foundation, poster prize
  • 2022 Open Bioinformatics Foundation (OBF), Event Fellowship (travel grant)
  • 2022 Helmholtz Information & Data Science Academy (HIDA) travel grant
  • 2021 Inflammatory Skin Disease Summit (ISDS) travel grant
  • 2019 Public Health Award Munich

Publications

*Rauer L & *De Tomassi A, Müller CL, Hülpüsch C, Traidl-Hoffmann C, *Reiger M & *Neumann AU

De-biasing microbiome sequencing data: bacterial morphology-based correction of extraction bias and correlates of chimera formation

*Hülpüsch C & *Rauer L, Nussbaumer T, Schwierzeck V, Bhattacharyya M, Erhart V, Traidl-Hoffmann C, *Reiger M & *Neumann AU

Benchmarking MicrobIEM - a user-friendly tool for decontamination of microbiome sequencing data

Simon LM, Flocco C, Burkart F, Methner A, Henke D, Rauer L, Müller CL, Vogel J, Quaisser C, Overmann J, Simon S

Microbial fingerprints reveal interaction between museum objects, curators, and visitors

*De Tomassi A & *Reiter A, Reiger M, Rauer L, Rohayem R, CK-Care Study Group, *Traidl-Hoffmann C & *Neumann AU & *Hülpüsch C

Combining 16S Sequencing and qPCR Quantification Reveals Staphylococcus aureus Driven Bacterial Overgrowth in the Skin of Severe Atopic Dermatitis Patients

Rauer L, Reiger M, Bhattacharyya M, Brunner PM, Krueger JG, Guttman-Yassky E, Traidl-Hoffmann C, Neumann AU

Skin microbiome and its association with host cofactors in determining atopic dermatitis severity