Niessing Lab Publications

2022 Scientific Article in Frontiers in Immunology Front. Immunol. 13:958952 (2022)

Kreft, L. ; Schepers, A. ; Hils, M. ; Swiontek, K. ; Flatley, A. ; Janowski, R. ; Mirzaei, M.K. ; Dittmar, M. ; Chakrapani, N. ; Desai, M.S. ; Eyerich, S. ; Deng, L. ; Niessing, D. ; Fischer, K. ; Feederle, R. ; Blank, S. ; Schmidt-Weber, C.B. ; Hilger, C. ; Biedermann, T. ; Ohnmacht, C.

A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.

2022 Scientific Article in Virulence Virulence 13, 483-501 (2022)

Jessberger, N. ; Diedrich, R. ; Janowski, R. ; Niessing, D. ; Märtlbauer, E.

Presence and function of Hbl B', the fourth protein component encoded by the hbl operon in Bacillus cereus.

2022 Scientific Article in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 20, 443-458 (2022)

Margreiter, M.A. ; Witzenberger, M. ; Wasser, Y. ; Davydova, E.-O. ; Janowski, R. ; Metz, J. ; Habib, P. ; Sahnoun, S.E.M. ; Sobisch, C. ; Poma, B. ; Palomino-Hernández, O. ; Wagner, M. ; Carell, T. ; Jon Shah, N. ; Schulz, J.B.&deg ; Niessing, D.&deg ; Voigt, A.&deg ; Rossetti, G.&deg

Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.

2021 Scientific Article in Nature Immunology Nat. Immunol. 22, 1563-1576 (2021)

Behrens, G.^# ; Edelmann, S.L.^# ; Raj, T.^# ; Kronbeck, N. ; Monecke, T. ; Davydova, E.-O. ; Wong, E.H. ; Kifinger, L. ; Giesert, F. ; Kirmaier, M.E. ; Hohn, C. ; de Jonge, L.S. ; Pisfil, M.G. ; Fu, M. ; Theurich, S. ; Feske, S. ; Kawakami, N. ; Wurst, W. ; Niessing, D. ; Heissmeyer, V.

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.

2021 Scientific Article in Nature Biotechnology Nat. Biotechnol., DOI: 10.1038/s41587-021-01100-5 (2021)

Mishra, K.^# ; Fuenzalida Werner, J.P.^# ; Pennacchietti, F. [extern]^# ; Janowski, R.^# ; Chmyrov, A. ; Huang, Y. ; Zakian Dominguez, C.M. ; Klemm, U. ; Testa, I. [extern] ; Niessing, D. ; Ntziachristos, V. ; Stiel, A.-C.

Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging.

2021 Scientific Article in Journal of Oral Biosciences J. Oral Biosci., DOI: 10.1016/j.job.2021.08.003 (2021)

Mehar, R. ; Swarnakar, S. ; Lakkakula, S. ; Verma, A.K. ; Bhaskar, L.V.K.S.

Interleukin-6 gene -174G>C promoter polymorphism reduces the risk of periodontitis in Brazilian populations: A meta-analysis.

2021 Scientific Article in Crystals Crystals 11:975 (2021)

Walla, B. ; Bischoff, D. ; Janowski, R. ; Von Den Eichen, N. ; Niessing, D. ; Weuster-Botz, D.

Transfer of a rational crystal contact engineering strategy between diverse alcohol dehydrogenases.

2021 Scientific Article in Crystals Crystals 11:588 (2021)

Hermann, J. ; Bischoff, D. ; Grob, P. ; Janowski, R. ; Hekmat, D. ; Niessing, D. ; Zacharias, M. ; Weuster-Botz, D.

Controlling protein crystallization by free energy guided design of interactions at crystal contacts.

2021 Scientific Article in The Plant cell Plant Cell 33, 714-734 (2021)

Bauer, S.^# ; Mekonnen, D.W.^# ; Hartmann, M. ; Yildiz, I. ; Janowski, R. ; Lange, B. ; Geist, B. ; Zeier, J.&deg ; Schäffner, A.&deg

UGT76B1, a promiscuous hub of small molecule-based immune signaling, glucosylates N-hydroxypipecolic acid, and balances plant immunity.

2021 Review in Frontiers in Genetics Front. Genet. 12:638217 (2021)

Molitor, L.^# ; Bacher, S.^# ; Burczyk, S. ; Niessing, D.

The molecular function of PURA andi Its implications in neurological diseases.

2021 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 49, 3507-3523 (2021)

Naarmann-de Vries, I.S. ; Senatore, R. ; Moritz, B. ; Marx, G. ; Urlaub, H. ; Niessing, D. ; Ostareck, D.H. ; Ostareck-Lederer, A.

Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis.

2020 Scientific Article in Analytical Chemistry Anal. Chem. 92, 10717-10724 (2020)

Fuenzalida Werner, J.P. ; Huang, Y. ; Mishra, K. ; Janowski, R. ; Vetschera, P. ; Heichler, C. ; Chmyrov, A. ; Neufert, C. ; Niessing, D. ; Ntziachristos, V. ; Stiel, A.-C.

Challenging a preconception: Optoacoustic spectrum differs from the absorption spectrum of proteins and dyes for molecular imaging.

2020 Scientific Article in EMBO Journal, The EMBO J.:e103373 (2020)

Esgleas Izquierdo, M. ; Falk, S. ; Forné, I. ; Thiry, M. ; Najas, S. ; Zhang, S. ; Mas-Sanchez, A. ; Geerlof, A. ; Niessing, D. ; Wang, Z. ; Imhof, A. ; Götz, M.

Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.

2020 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 48, 7385-7403 (2020)

Binas, O. ; Tants, J.N. ; Peter, S.A. ; Janowski, R. ; Davydova, E.-O. ; Braun, J. ; Niessing, D. ; Schwalbe, H. ; Weigand, J.E.&deg ; Schlundt, A.&deg

Structural basis for the recognition of transiently structured AU-rich elements by Roquin.

2020 Scientific Article in RNA Biology RNA Biol. 17, 1228-1238 (2020)

Janowski, R. ; Niessing, D.

The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life.

2020 Scientific Article in Biotechnology Journal Biotechnol. J. 15:2000010 (2020)

Grob, P. ; Huber, M. ; Walla, B. ; Hermann, J. ; Janowski, R. ; Niessing, D. ; Hekmat, D. ; Weuster-Botz, D.

Crystal contact engineering enables efficient capture and purification of an oxidoreductase by technical crystallization.

2020 Scientific Article in Molecular Pharmaceutics Mol. Pharm. 17, 1663-1673 (2020)

Su, W. ; Tan, H. ; Janowski, R. ; Zhang, W. ; Wang, P. ; Zhang, J. ; Zhai, H. ; Li, J. ; Niessing, D. ; Sattler, M. ; Zou, P.

Ferritin-displayed GLP-1 with improved pharmacological activities and pharmacokinetics.

2019 Scientific Article in Neurology Genetics Neurol. Genet. 5:e373 (2019)

Johannesen, K. ; Mitter, D. ; Janowski, R. ; Roth, C. ; Toulouse, J. ; Poulat, A. ; Ville, D.M. ; Chatron, N. ; Brilstra, E. ; Geleijns, K. ; Born, A.P. ; McLean, S. ; Nugent, K. ; Baynam, G. ; Poulton, C. ; Dreyer, L. ; Gration, D. ; Schulz, S. ; Dieckmann, A. ; Helbig, K.L. ; Merkenschlager, A. ; Jamra, R. ; Finck, A. ; Gardella, E. ; Hjalgrim, H. ; Mirzaa, G. ; Brancati, F. ; Bierhals, T. ; Denecke, J. ; Hempel, M. ; Lemke, J.R. ; Rubboli, G. ; Muschke, P. ; Guerrini, R. ; Vetro, A. ; Niessing, D. ; Lesca, G. ; Moller, R.S.

Defining and expanding the phenotype of QARS-associated developmental epileptic encephalopathy.

2019 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 49, 221-222 (2019)

Behrens, G. ; Nina, K. ; Csaba, G. ; Raj, T. ; Monecke, T. ; Zimmer, R. ; Niessing, D. ; Heissmeyer, V.

Roquin and Regnase-1 cooperatively determine cell fate decisions in T cells.

2019 Scientific Article in Nature Communications Nat. Commun. 10:2266 (2019)

Schneider, T. ; Hung, L.H. ; Aziz, M. ; Wilmen, A. ; Thaum, S. ; Wagner, J. ; Janowski, R. ; Müller, S. ; Schreiner, S. ; Friedhoff, P. ; Hüttelmaier, S. ; Niessing, D. ; Sattler, M.&deg ; Schlundt, A.&deg ; Bindereif, A.&deg

Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.

2019 Scientific Article in Stem Cell Reports Stem Cell Rep. 12, 861-868 (2019)

Matheus, F. ; Rusha, E. ; Rehimi, R. ; Molitor, L. ; Pertek, A. ; Modic, M. ; Feederle, R. ; Flatley, A. ; Kremmer, E. ; Geerlof, A. ; Rishko, V. ; Rada-Iglesias, A. ; Drukker, M.

Pathological ASXL1 mutations and protein variants impair neural crest development.

2019 Scientific Article in Nature Communications Nat. Commun. 10:1659 (2019)

Heber, S. ; Gáspár, I. ; Tants, J.-N. ; Günther, J. ; Fernandez Moya, S.M. ; Janowski, R. ; Ephrussi, A. ; Sattler, M. ; Niessing, D.

Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.

2018 Scientific Article in Journal of Structural Biology J. Struct. Biol. 204, 519-522 (2018)

Fuenzalida Werner, J.P.^# ; Janowski, R.^# ; Mishra, K. ; Weidenfeld, I. ; Niessing, D. ; Ntziachristos, V. ; Stiel, A.-C.

Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.

2018 Scientific Article in OncoTarget Oncotarget 9, 29365-29378 (2018)

Wȩglarz-Tomczak, E. ; Talma, M. ; Giurg, M. ; Westerhoff, H.V. ; Janowski, R. ; Mucha, A.

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.

2018 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 293, 8994-9005 (2018)

Tretter, J. ; Schorpp, K.K. ; Luxenburger, E. ; Trambauer, J. ; Steiner, H. ; Hadian, K. ; Gires, O. ; Niessing, D.

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.

2018 Scientific Article in Cell Cell 173, 706-719.e13 (2018)

Hofweber, M. ; Hutten, S. ; Bourgeois, B. ; Spreitzer, E. ; Niedner-Boblenz, A. ; Schifferer, M. ; Ruepp, M.D. ; Simons, M. ; Niessing, D. ; Madl, T. ; Dormann, D.

Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation.

2018 Scientific Article in Nature Communications Nat. Commun. 9:299 (2018)

Rehage, N. ; Davydova, E.-O. ; Conrad, C. ; Behrens, G. ; Maiser, A. ; Stehklein, J.E. ; Brenner, S. ; Klein, J. ; Jeridi, A. ; Hoffmann, A.L. ; Lee, E. ; Dianzani, U. ; Willemsen, R. ; Feederle, R. ; Reiche, K. ; Hackermüller, J. ; Leonhardt, H. ; Sharma, S.&deg ; Niessing, D. ; Heissmeyer, V.&deg

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.

2017 Scientific Article in Journal of Visualized Experiments J. Vis. Exp.:e54886 (2017)

Zalewski, J.K. ; Heber, S. ; Mo, J.H. ; O'Conor, K. ; Hildebrand, J.D. ; VanDemark, A.P.

Combining wet and dry lab techniques to guide the crystallization of large coiled-coil containing proteins.

2017 Scientific Article in Journal of Medical Genetics J. Med. Genet. 55, 104-113 (2017)

Reijnders, M.R. ; Janowski, R. ; Alvi, M. ; Self, J.E. ; van Essen, T.J. ; Vreeburg, M. ; Rouhl, R.P.W. ; Stevens, S.J.C. ; Stegmann, A.P.A. ; Schieving, J. ; Pfundt, R. ; van Dijk, K.D. ; Smeets, E.E. ; Stumpel, C.T.R.M. ; Bok, L.A. ; Cobben, J.M. ; Engelen, M. ; Mansour, S. ; Whiteford, M. ; Chandler, K.E. ; Douzgou, S. ; Cooper, N.S. ; Tan, E.C. ; Foo, R. ; Lai, A.H.M. ; Rankin, J. ; Green, A.R. ; Lönnqvist, T. ; Isohanni, P. ; Williams, S. ; Ruhoy, I. ; Carvalho, K.S. ; Dowling, J.J. ; Lev, D.L. ; Sterbova, K. ; Lassuthova, P. ; Neupauerová, J. ; Waugh, J.L. ; Keros, S. ; Clayton-Smith, J. ; Smithson, S.F. ; Brunner, H.G. ; van Hoeckel, C. ; Anderson, M.D. ; Clowes, V.E. ; Siu, V.M. ; Ddd Study, T. ; Selber, P. ; Leventer, R.J. ; Nellaker, C. ; Niessing, D. ; Hunt, D.T.E. ; Baralle, D.

PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature.

2017 Meeting abstract in FEBS Journal, The FEBS J. 284, 263-263 (2017)

Tretter, J. ; Schorpp, K.K. ; Luxenburger, E. ; Hadian, K. ; Gires, O. ; Niessing, D.

Innovative therapeutic modalities for solid EpCAM-positive tumours.

2017 Scientific Article in Wiley Interdisciplinary Reviews: RNA Wiley Interdiscip. Rev. RNA 9, DOI: 10.1002/wrna.1453 (2017)

Niessing, D. ; Jansen, R.P. ; Pohlmann, T ; Feldbrügge, M.

mRNA transport in fungal top models.

2017 Scientific Article in Toxins Toxins 9:288 (2017)

Tausch, F. ; Dietrich, R. ; Schauer, K. ; Janowski, R. ; Niessing, D. ; Märtlbauer, E. ; Jessberger, N.

Evidence for complex formation of the Bacillus cereus haemolysin BL components in solution.

2017 Review in BioSpektrum BioSpektrum 23, 510-512 (2017)

Jansen, R.P.&deg ; Niessing, D.&deg

mRNA-Lokalisation: Wenn RNAs auf Reise gehen …

2017 Scientific Article in Scientific Reports Sci. Rep. 7:1051 (2017)

Schlundt, A. ; Buchner, S. ; Janowski, R. ; Heydenreich, T. ; Heermann, R. ; Lassak, J. ; Geerlof, A. ; Stehle, R. ; Niessing, D. ; Jung, K. ; Sattler, M.

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.

München, Technische Universität, Fakultät für Chemie, Diss., 2017, 185 S.

Edelmann, F.

Structural and functional characterization of the ASH1-mRNP transport-complex from budding yeast.

2017 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 152-161 (2017)

Edelmann, F. ; Schlundt, A. ; Heym, R.G. ; Jenner, A. ; Niedner-Boblenz, A. ; Syed, M.I. ; Paillart, J.C. ; Stehle, R. ; Janowski, R. ; Sattler, M. ; Jansen, R.P. ; Niessing, D.

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.

2016 Scientific Article in Acta crystallographica / International Union of Crystallography Act. Cryst. F 72, 743-749 (2016)

Janowski, R. ; Scanu, S. ; Niessing, D. ; Madl, T.

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.

2016 Scientific Article in Nature Communications Nat. Commun. 7:11032 (2016)

Janowski, R.^# ; Heinz, G.A.^# ; Schlundt, A.^# ; Wommelsdorf, N. ; Brenner, S. ; Gruber, A.R. ; Blank, M. ; Buch, T. ; Buhmann, R. ; Zavolan, M. ; Niessing, D.&deg ; Heissmeyer, V.&deg ; Sattler, M.&deg

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.

2016 Review in Wiley Interdisciplinary Reviews: RNA Wiley Interdiscip. Rev. RNA 7, 455-469 (2016)

Schlundt, A. ; Niessing, D. ; Heissmeyer, V. ; Sattler, M.

RNA recognition by Roquin in posttranscriptional gene regulation.

2016 Scientific Article in eLife eLife 5:e11297 (2016)

Weber, J. ; Bao, H. ; Hartlmüller, C. ; Wang, Z. ; Windhager, A. ; Janowski, R. ; Madl, T. ; Jin, P. ; Niessing, D.

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.

2016 Scientific Article in Scientific Reports Sci. Rep. 6:18934 (2016)

Vincendeau, M. ; Hadian, K. ; Messias, A.C. ; Brenke, J.K. ; Halander, J. ; Griesbach, R.A. ; Greczmiel, U. ; Bertossi, A. ; Stehle, R. ; Nagel, D. ; Demski, K. ; Velvarska, H. ; Niessing, D. ; Geerlof, A. ; Sattler, M. ; Krappmann, D.

Inhibition of canonical NF-κB signaling by a small molecule targeting NEMO-ubiquitin interaction.

2016 Scientific Article in ACS Chemical Biology ACS Chem. Biol. 11, 1001-1011 (2016)

Morgen, M. ; Jöst, C. ; Malz, M. ; Janowski, R. ; Niessing, D. ; Klein, C.D. ; Gunkel, N. ; Miller, A.K.