Stem Cell Center
Institute of Stem Cell Research
The Institute of Stem Cell Research (ISF) investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation (Camargo et al., Nature, 2019, O'Neill et al., Science, 2022). On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair (Russo et al., Cell Stem Cell, 2021, Sonsala et al., Neuron, 2024, Pereira et al., Nature Neuroscience, 2024).
The Institute of Stem Cell Research (ISF) investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation (Camargo et al., Nature, 2019, O'Neill et al., Science, 2022). On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair (Russo et al., Cell Stem Cell, 2021, Sonsala et al., Neuron, 2024, Pereira et al., Nature Neuroscience, 2024).
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Our Publications
Hennes, M. ; Richter, M. ; Fischer-Sternjak, J. ; Götz, M.
Astrocyte diversity and subtypes: Aligning transcriptomics with multimodal perspectives.Martinez-Reza, M.F. ; Götz, M.
Wrap it up: Myelination of transplanted neurons for repair.Merino, F.L. ; Götz, M.
The role of moonlighting proteins in neurogenesis.Maddhesiya, P. ; Lepko, T. ; Steiner‑Mezzardi, A. ; Schneider, J. ; Schwarz, V. ; Merl-Pham, J. ; Berger, F. ; Hauck, S.M. ; Ronfani, L. ; Bianchi, M.E. ; Simon, T. ; Krontira, A. ; Masserdotti, G. ; Götz, M. ; Ninkovic, J.
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner.Götz, M. ; Torres-Padilla, M.E.
Stem cells as role models for reprogramming and repair.Bocchi, R. ; Thorwirth, M. ; Simon-Ebert, T. ; Koupourtidou, C. ; Clavreul, S. ; Kolf, K. ; Della Vecchia, P. ; Bottes, S. ; Jessberger, S. ; Zhou, J. ; Wani, G. ; Pilz, G.A. ; Ninkovic, J. ; Buffo, A. ; Sirko, S. ; Götz, M. ; Fischer-Sternjak, J.
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter.Natarajan, P. ; Koupourtidou, C. ; de Resseguier, T. ; Thorwirth, M. ; Bocchi, R. ; Fischer-Sternjak, J. ; Gleiss, S. ; Rodrigues, D. ; Myoga, M.H. ; Ninkovic, J. ; Masserdotti, G. ; Götz, M.
Single cell deletion of the transcription factors Trps1 and Sox9 in astrocytes reveals novel functions in the adult cerebral cortex.Puglisi, M. ; Lao, C.L. ; Wani, G. ; Masserdotti, G. ; Bocchi, R. ; Götz, M.
Comparing viral vectors and fate mapping approaches for astrocyte-to-neuron reprogramming in the injured mouse cerebral cortex.Pereira, A. ; Diwakar, S.J. ; Masserdotti, G. ; Beşkardeş, S. ; Simon, T. ; So, Y. ; Martín-Loarte, L. ; Bergemann, F. ; Vasan, L. ; Schauer, T. ; Danese, A. ; Bocchi, R. ; Colomé-Tatché, M. ; Schuurmans, C. ; Philpott, A. ; Straub, T. ; Bonev, B. ; Götz, M.
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.Berndt, C. ; Alborzinia, H. ; Amen, V.S. ; Ayton, S. ; Barayeu, U. ; Bartelt, A. ; Bayir, H. ; Bebber, C.M. ; Birsoy, K. ; Böttcher, J.P. ; Brabletz, S. ; Brabletz, T. ; Brown, A.R. ; Brüne, B. ; Bulli, G. ; Bruneau, A. ; Chen, Q. ; DeNicola, G.M. ; Dick, T.P. ; Distéfano, A. ; Dixon, S.J. ; Engler, J.B. ; Esser-von Bieren, J. ; Fedorova, M. ; Friedmann Angeli, J.P. ; Friese, M.A. ; Fuhrmann, D.C. ; García-Sáez, A.J. ; Garbowicz, K. ; Götz, M. ; Gu, W. ; Hammerich, L. ; Hassannia, B. ; Jiang, X. ; Jeridi, A. ; Kang, Y.P. ; Kagan, V.E. ; Konrad, D.B. ; Kotschi, S. ; Lei, P. ; Le Tertre, M. ; Lev, S. ; Liang, D. ; Linkermann, A. ; Lohr, C. ; Lorenz, S. ; Luedde, T. ; Methner, A. ; Michalke, B. ; Milton, A.V. ; Min, J. ; Mishima, E. ; Müller, S. ; Motohashi, H. ; Muckenthaler, M.U. ; Murakami, S. ; Olzmann, J.A. ; Pagnussat, G.C. ; Pan, Z. ; Papagiannakopoulos, T. ; Pedrera Puentes, L. ; Pratt, D.A. ; Proneth, B. ; Ramsauer, L. ; Rodriguez, R. ; Saito, Y. ; Schmidt, F. ; Schmitt, C. ; Schulze, A. ; Schwab, A. ; Schwantes, A. ; Soula, M. ; Spitzlberger, B. ; Stockwell, B.R. ; Thewes, L. ; Thorn-Seshold, O. ; Toyokuni, S. ; Tonnus, W. ; Trumpp, A. ; Vandenabeele, P. ; Vanden Berghe, T. ; Venkataramani, V. ; Vogel, F.C.E. ; von Karstedt, S. ; Wang, F. ; Westermann, F. ; Wientjens, C. ; Wilhelm, C. ; Wölk, M. ; Wu, K. ; Yang, X. ; Yu, F. ; Zou, Y. ; Conrad, M.
Ferroptosis in health and disease.Del-Valle-Anton, L. ; Amin, S.A. ; Cimino, D. ; Neuhaus, F. ; Dvoretskova, E. ; Fernandez, V. ; Babal, Y.K. ; Garcia-Frigola, C. ; Prieto-Colomina, A. ; Murcia-Ramón, R. ; Nomura, Y. ; Cárdenas, A. ; Feng, C. ; Moreno-Bravo, J.A. ; Götz, M. ; Mayer, C. ; Borrell, V.
Multiple parallel cell lineages in the developing mammalian cerebral cortex.Koupourtidou, C. ; Schwarz, V. ; Aliee, H. ; Frerich, S. ; Fischer-Sternjak, J. ; Bocchi, R. ; Simon-Ebert, T. ; Bai, X. ; Sirko, S. ; Kirchhoff, F. ; Dichgans, M. ; Götz, M. ; Theis, F.J. ; Ninkovic, J.
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.Schieweck, R. ; Götz, M.
Pan-cellular organelles and suborganelles-from common functions to cellular diversity?Sonsalla, G. ; Malpartida, A.B. ; Riedemann, T. ; Gusic, M. ; Rusha, E. ; Bulli, G. ; Najas, S. ; Janjic, A. ; Hersbach, B.A. ; Smialowski, P. ; Drukker, M. ; Enard, W. ; Prehn, J.H.M. ; Prokisch, H. ; Götz, M. ; Masserdotti, G.
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.Popper, B. ; Bürkle, M. ; Ciccopiedi, G. ; Marchioretto, M. ; Forné, I. ; Imhof, A. ; Straub, T. ; Viero, G. ; Götz, M. ; Schieweck, R.
Ribosome inactivation regulates translation elongation in neurons.