IEG

The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.

The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.

The characterization of mutants represents a valuable instrument for functional genome analysis. Novel mouse models for metabolic diseases are in the center of our projects. By unraveling the molecular pathways and pathophysiological events leading, in particular, to diabetes we also transfer the basic research results into the development of novel strategies for diagnosis, prevention and therapy.

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Our research focuses on the epigenetic inheritance of metabolic diseases such as obesity and diabetes mostly using the mouse as functional model system. We aim to understand how metabolic phenotypes that are acquired during life - for example, by malnutrition - are inherited from one generation to the next. We want to contribute to a better understanding of this inter-generational epigenetic inheritance and its implications for the observed pandemic of obesity and diabetes in man.

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DNA strands on Scientific background. 3d illustration, modified

Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.
Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.
We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.

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The German Mouse Clinic (GMC) as an open access phenotyping platform offers comprehensive phenotyping of mouse models in a systemic primary screen. Scientists with expert knowlegde from various fields of mouse physiology and pathology work together on evaluating numerous physiological pathways.

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The European Mouse Mutant Archive is an INFRAFRONTIER core service for collection, archiving and distribution of mutant mice valuable for scientific and medical research. The IEG is one INFRAFRONTIER partner operating the German EMMA node with a main focus on cryopreservation and in vitro fertilization.

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Advances in medical research revealed that a disease phenotype is the result of pathobiological processes that interact in complex networks. A large body of information generated in decades of experimental research is hidden in the scientific literature.
Our aim is to generate high-quality databases that describe experimentally validated interactions between molecules and processes involved in the development of diseases.

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Data funnel abstract technology background. Big data technology stream filter analytic sort. AI network filter

We initiate and take lead in projects that use artificial intelligence methods on large mouse phenotyping datasets from the German Mouse Clinic (GMC) or from external sources.
We develop and maintain highly customised IT infrastructure and solutions for our institute. Such as the in-house developed application "MausDB" , a modular laboratory information management system (LIMS).
And we support IEG research projects internally with our IT expertise and tools.

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Harrer, P. ; Kranz, A. ; Becker, L. ; Garrett, L. ; Hölter, S.M. ; Sanz-Moreno, A. ; Amarie, O.V. ; Rathkolb, B. ; Leuchtenberger, S. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Saparov, A. ; Sieber, C. ; Kittke, V. ; Mirza-Schreiber, N. ; Stewart, A.F. ; Winkelmann, J. ; Oexle, K. ; Pocratsky, A. ; Zech, M.

Motor coordination and behavioural deficits in a mouse model of KMT2B-related dystonia.

Braunsperger, A. ; Becker, L. ; Camargo, D.P. ; Radsak, S. ; Paintner, M. ; Kossenakis, D. ; Song, X. ; Kraus, A. ; Birnkammer, A. ; Mesmer, S. ; Stengel, J. ; Frank, L. ; Kuger, S. ; Mather, T. ; Paltola, E. ; Köhnen, M. ; Liebetanz, K. ; Zorn, J. ; de Angelis, M. ; Hrabě de Angelis, M. ; Tischer, D. ; Soriano‐Arroquia, A. ; Georgiadi, A. ; Schönfelder, M. ; Wackerhage, H.

6 weeks of fartlek-sytle endurance training does not alter physiological responses to mild cold exposure but attenuates the cold-induced plasma noradrenaline response: A randomized, matched control trial.

Berleth, T. ; Hardtke, C.S. ; Mattson, J. ; Przemeck, G.K.H.

A genetic access to plant cell axis formation.

Chang, R.C. ; Avila, M. ; Huang, Y. ; To, K. ; Aguilar-Pimentel, J.A. ; Adler, T. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Blumberg, B.

Maternal tributyltin exposure is associated with male-biased immune dysregulation across generations.

Wang, Y. ; Sargent, J.L. ; Mathieu, C. ; Vazquez-Arreola, E. ; Perreault, L. ; Loos, R.J.F. ; Lim, L. ; Sandforth, L. ; Hanson, R.L. ; Kullmann, S. ; Sbierski-Kind, J. ; Brucker, S.Y. ; Hrabě de Angelis, M. ; Theis, F.J. ; Icks, A. ; Mohebbi, D. ; Stefan, N. ; Mohan, V. ; Wang, T. ; Preissl, H. ; Bergman, M. ; Tuomilehto, J. ; Hivert, M. ; Franks, P.W. ; Birkenfeld, A.L.

Type 2 diabetes prevention across the life course.

Molenaar, A. ; Pathak, E. ; Bernecker, M. ; Mallet, N. ; Gutierrez-Aguilar, R. ; Mencias Castillejo, C. ; Lutter, D. ; de Angelis, M. ; Maity-Kumar, G. ; Kühnen, P. ; Obermayer, B. ; Opitz, R. ; Müller, T.D. ; Schriever, S.C. ; Pfluger, P.T.

Central thyroid hormone deprivation disrupts cortical cilia and oligodendrocyte lineage in an Allan-Herndon-Dudley-Syndrome mouse model.

Moshiri, A. ; Kasiri, N. ; Shea, M. ; Ali, L. ; Yang, B. ; Shao, A. ; Clary, D. ; Flenniken, A.M. ; Eskandarian, M. ; Amarie, O.V. ; Becker, L. ; Sangermano, R. ; Place, E.M. ; Bujakowska, K.M. ; Huckfeldt, R.M. ; Berberovic, Z. ; Bour, R. ; Riet, F. ; Brown, S.D. ; D'Souza, A. ; Fuchs, H. ; Gailus-Durner, V. ; Guimond, A. ; Hérault, Y. ; Hrabě de Angelis, M. ; Lux, A. ; Mittelhauser, C. ; Nutter, L.M.J. ; Palkova, M. ; Lindovsky, J. ; Petit-Demouliere, B. ; Prochazka, J. ; Bradaschia, V. ; Kelsey, L. ; McKerlie, C. ; Raishbrook, M.J. ; Sedlacek, R. ; Lanoue, L. ; Lloyd, K.K. ; Roux, M.J. ; Bermingham-McDonogh, O.

Searching for new genes that cause usher syndrome.

Selloum, M. ; da Silva Buttkus, P. ; Riet, F. ; Dragano, N.R.V. ; Garrett, L. ; Jacobs, H. ; Hölter, S.M. ; Torquet, N. ; Rathkolb, B. ; Lindner, L. ; Gailus-Durner, V. ; Pavlovic, G. ; Chan, L. ; Beckers, J. ; Demoulière, B.P. ; Fuchs, H. ; Ey, E. ; Sorg, T. ; Hrabě de Angelis, M. ; Herault, Y.

Standardized pipeline for metabolism and cognition in GO-DS21 mouse model: Investigating down syndrome comorbidities.

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Prof. Dr. Dr. h.c. Martin Hrabě De Angelis

Member and Spokesperson of the Executive Board (acting), Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich, Director of the Institute of Experimental Genetics Helmholtz Munich

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