Environmental Health Center

Lung Health and Immunity

Many environmentally triggered lung diseases are still considered incurable. We explore the immunological mechanisms underlying chronic lung diseases such as COPD, lung fibrosis, asthma, lung cancer and the complications following lung transplantation. We want to translate our findings into preventative and therapeutic approaches for patients.

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Many environmentally triggered lung diseases are still considered incurable. We at the Institute of Lung Health and Immunity (LHI) explore the immunological mechanisms underlying chronic lung diseases such as COPD, lung fibrosis, asthma, lung cancer and the complications following lung transplantation. We want to translate our findings into preventative and therapeutic approaches for patients.

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We are hiring!

Our Research Areas

Lead: Isis Fernandez

The investigation of structural-immune and immune-immune cell interaction, reprogramming and the pulmonary epimmunome facilitates a better understanding of the pathogenesis of chronic pulmonary diseases. It will lead us to immune-driven target identification and prioritization to broaden the therapeutic landscape in chronic lung diseases.

Lead: Theodoros Kapellos

Our disease area envisions to advance the understanding and treatment of pulmonary diseases by utilizing and developing cutting-edge statistical and systems tools. Our focus on translational models allows us to validate findings from innovative tools in patient biomaterial and bridge scales from cells to tissue niches and organs, ensuring translational impact on biomarkers and diagnostics.

Lead: Tobias Stöger

We investigate the cellular pathways maintaining the functionality of the respiratory barrier and how tissue homeostasis gets affected by environmental challenges. Our focus has been on exposure scenarios of cigarette smoke and combustion, derived or engineered nanoparticles and their contribution to the development of chronic lung diseases.

Our Labs

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Burgstaller Lab

Immunotherapeutic Technologies

Cancer cell attacking another cell

Diefenbacher Lab

Experimental Immuno-Oncology

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Fernandez Lab

Immune networks in chronic lung diseases

Human lung model

Funk Lab

Ageing & Environmental stress in lung disease

bronchoalveolar lavage gerckens mümmler

Gerckens/Mümmler Lab

Lung Transplantation: Therapeutic Immunology

Emphysema as shortness of breath, lung disorder as a COPD illness and Chronic obstructive pulmonary disease medical concept as bronchioles and alveoli are damaged.

Jeridi Lab

Lung Immunity and Cell Death

3d rendering of Human cell

Kapellos Lab

Immunoregulation in obstructive respiratory diseases

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Lehmann Lab

Lung Inflammaging

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Lindermayr Lab

Trained Immunity

KI-Grafik (Firefly) einer Lunge mit Weltkarte, Lücken Lab

Lücken Lab

Integrative Genomics

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Rehberg Lab

Intravital microscopy of barrier immunity

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Schmid Lab

Pulmonary Aerosol Delivery

LHI-stoeger_iAT2-IPF-fibroblasts

Stöger Lab

Dynamics of Pulmonary Inflammation

Graphic illustration of alveoli with COPD

Yildirim/Conlon Lab

Immunopathology of COPD

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CPC-M bioArchive

white mouse with food bowl

SMAP - Small Animal Platform

News

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T-cells in the alveolar region

New Research Findings, Environmental Health, LHI,

SARS-CoV-2: Real-time Imaging Reveals Unexpectedly Fast Immune Response in the Lung

Using advanced intravital microscopy, Helmholtz Munich researchers have been able to observe early immune reactions in the living lung in real time. The images show that specific T cells are activated within hours after contact with components of…

double portrait of Erika von Mutius and Önder Yildirim

Environmental Health, IAP, LHI,

Farm Dust Could Hold the Key to Preventing Asthma

For decades, scientists have puzzled over a striking observation: children who grow up on traditional farms are far less likely to develop allergies or asthma than their urban peers. What is it about farm life that protects young lungs?

Doppelportrait-Wasnick-Lehmann

Environmental Health, LHI,

New perspectives on lung repair: cellular plasticity as a key to regeneration

How the lung regenerates after injury and the role played by specific cell types are at the center of a recent review article by LHI researchers Roxana Wasnick and Mareike Lehmann.

Nanomaterial - Gewebe

Environmental Health, PRM, LHI,

ToxAtlas: How Inhaled Nanomaterials Trigger Lung Inflammation at the Cellular Level

A new international study led by Dr. Tobias Stöger (LHI, Helmholtz Munich) and Prof. Herbert Schiller (PRM, Helmholtz Munich) has provided new insights into how inhaled nanomaterials spark inflammatory responses in the lungs.

Bloodstream Flow 3D Render of Red Blood Cells in Vessel Lumen

Awards & Grants, Environmental Health, LHI, Molecular Targets and Therapeutics, MCD,

Funding for Cell Death Research Extended

Research into a novel form of cell death is entering its next phase and could soon help reduce complications after heart attacks or organ transplants. The Federal Ministry of Research, Technology, and Space (BMFTR) is providing continued support for…

Futuristic medical concept with red human lungs. Abstract geometric design with plexus effect on dark background. Healthcare and pulmonology banner with copy space.

Events, Environmental Health, LHI,

ERS–COPD-iNET: International Research Symposium Highlights Opportunities for Early Intervention in COPD

The European Respiratory Society (ERS) and COPD-iNET Research Symposium in Prague brought together more than 120 clinicians, researchers, and patient advocates to address one of the most pressing challenges in respiratory medicine: Chronic…

COPD Lung Day 2025

Environmental Health, LHI,

World COPD Day 2025

World COPD Day aims to raise awareness, share knowledge, and promote action to reduce the global burden of chronic obstructive pulmonary disease (COPD). Helmholtz Munich is driving progress in these efforts, with pioneering research on new…

Center Template, Icon, Featured Publication, Environmental Health

Featured Publication, Environmental Health, LHI,

How Lung Cells Initiate the Immune Response to Nanoparticles

When nanoparticles enter the lungs, the immune system reacts within minutes. Researchers from the Institute of Lung Health and Immunity (LHI) at Helmholtz Munich have now revealed how alveolar macrophages – immune cells located in the lung’s air sacs…

Scientists at LHI

Gerald Burgstaller LHI
Dr. rer. nat. Gerald Burgstaller

Group Leader, LHI

Thomas Conlon LHI
Dr. Thomas Conlon

Group Leader, LHI

Diefenbacher_Markus_LHI_Portrait
Prof. Dr. Markus Diefenbacher

Group Leader, LHI

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Isis Fernandez Mitarbeiterfoto LHI
Dr. Isis E. Fernandez

Group Leader, LHI

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Frankenberger_Marion_LHI_FREI
Dr. Marion Frankenberger

Deputy Director LHI/Head of CPC-M bioArchive, LHI

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Porträt Maja Funk
Dr. Maja Funk

Junior Group Leader, LHI

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Portrait Michael Gerckens LHI
Dr. Michael Gerckens

Group Leader / Clinician Scientist, LHI

Portrait Aicha Jeridi, LHI
Dr. Aicha Jeridi

Group Leader, LHI

Theodoros Kapellos LHI
Dr. Theodoros Kapellos

Group Leader, LHI

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Mareike Lehmann LHI
Prof. Dr. Mareike Lehmann

Group Leader, LHI

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Christian Lindermayr LHI
Prof. Dr. Christian Lindermayr

Group Leader, LHI

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Portrait Malte Lücken, LHI (transparent)
Dr. Malte Lücken

Group Leader, ICB, LHI

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Mümmler_Carlo_Portrait
Dr. Carlo Mümmler

Group Leader / Clinician Scientist, LHI

Portrait Markus Rehberg LHI
Prof. Dr. Markus Rehberg

Group Leader, LHI

Schmid_Otmar_LHI_trans
Dr. Otmar Schmid

Group Leader, LHI

Stöger_Tobias_FREI
Dr. Tobias Stöger

Group Leader, LHI

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Strobl_Lothar_Portrait
Lothar J. Strobl

Group Leader, LHI

Portrait Roxana Wasnick LHI
Dr. Roxana Wasnick

Scientific Management, LHI

Portraet-Ali-Oender-Yildirim_freigestellt
Prof. Dr. Ali Önder Yildirim

Director Institute of Lung Health and Immunity, LHI

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Contact

Porträt Jiangningna Zhu
Jiangningna Zhu

Assistant of the Director, LHI

Director

Portraet-Ali-Oender-Yildirim_freigestellt
Prof. Dr. Ali Önder Yildirim

Director Institute of Lung Health and Immunity, LHI

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Deputy Director

Frankenberger_Marion_LHI_FREI
Dr. Marion Frankenberger

Deputy Director LHI/Head of CPC-M bioArchive, LHI

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Management

Franziska Hauptkorn Mitarbeiterbild LHI
Franziska Hauptkorn

Head of Operations Management, LHI

Scientific Management

Portrait Roxana Wasnick LHI
Dr. Roxana Wasnick

Scientific Management, LHI

Locations/How to reach us

Institute of Lung Health and Immunity (LHI)

Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Ingolstädter Landstraße 1,
D-85764 Neuherberg, Germany

Telephone: +49 89 3187-3071
E-Mail: info-lhi@helmholtz-munich.de

A petri dish with growing cultures of microorganisms, fungi and microbes. A Petri dish  ( Petrie dish) known as a Petri plate or cell-culture dish

yellow colonies on blue background

Environmental Health and Lung Research School

A structured translational training and education platform to ultimately raise future leaders in environmental health medicine and science

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Partners

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Deutsches Zentrum für Lungenforschung

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