Scientific Focus
The primary objective of the Institute of Diabetes and Regeneration Research (IDR) at the Helmholtz Diabetes Center München is to develop regenerative therapeutic approaches to treat diabetes mellitus - complementary and alternative to the classical immunological and metabolic therapy strategies. Therefore, the aim is to improve current strategies for functional β-cell production in vitro with the ultimate goal to provide alternative sources of β-cells for cell replacement therapy in diabetes. Additionally, we analyze and characterize the embryonic and adult pancreatic progenitor cells to understand β-cell development, homeostasis and function for in vivo regeneration. Triggering endogenous β-cell regeneration is a promising approach to restore beta cell mass and normoglycemia in diabetic patients.
Selected Publications
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Ansarullah, Jain, C., Far, F.F. et al. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Nature 590, 326–331 (2021).
Böttcher, A., Büttner, M., et al. Non-canonical Wnt/PCP signaling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates, Nature Cell Biology, 2021
Nature News & Views: More is better: combinatorial therapy to restore β-cell function in diabetes (comment on Sachs, S., Bastidas-Ponce, A., et al., 2020)
Research Highlight - Nature Reviews Endocrinology: Restoring β-cells (comment on Sachs, S., Bastidas-Ponce, A., et al., 2020)
Fischer, D.S,, Fiedler, A.K., et al., Inferring population dynamics from single-cell RNA-sequencing time series data. Nature Biotechnology, 2019 (in cooperation with the lab of Fabian Theis)
Bakhti, M., Böttcher, A., Lickert, H., Modelling the endocrine pancreas in health and disease, Nature Reviews Endocrinology, 2018 (Highly cited paper: top 1% of papers of similar age in field of clinical medicine)
Tritschler, S., Theis, F., Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas, Molecular Metabolism, 2017 (in cooperation with the lab of Fabian Theis)
Bader, E., Migliorini, A. et al., Identification of proliferative and mature β-cells in the islet of Langerhans. Nature, 2016
Nature News & Views: Pancreatic β-cell heterogeneity revisited (comment on Bader, E., Migliorini, A., et al., 2016)
Nature Reviews Endocrinology | Research Highlight: β-cell heterogeneity - key to unlocking islet regeneration (comment on Bader, E., Migliorini, A., et al., 2016)
Journal of Diabetes Investigation | Commentary: Heterogeneity of β-cells (comment on Bader, E., Migliorini, A., et al., 2016)
Independent Group "Woman and Diabetes"
All our publications
News
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11.05.2022 DZD AWARDS 2021: congratulations to Johanna, Weiwei and Alireza!
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29.04.2022 Congratulations to Heiko Lickert for winning an ERC Advanced Grant with the project...
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19.11.2021 Listen at Heiko Lickert describing his involvement into EU ISLET Consortium!
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18.11.2021 NIKON YOUNG SCIENTIST AWARD OF THE DGZ for Katharina Scheibner
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15.11.2021 LickertHeiko and Carolin Daniel are answering some questions for us on the perspectives on the...
Institute life
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Congratulations to Aimée Bastidas-Ponce for successfully defending her PhD thesis
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PhD students Sarah Homberg and Xianming Wang winners of DZD Award 2019
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PhD students Sára Bileková and Stephan Sachs winner of 1st HRD 3MT® Competition
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PhD students Katharina Scheibner and Lena Oppenländer winners of DZD Award 2018